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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

5-Aminotetrazoles – An Overview of Synthetic Methodologies through the Desulfurization of Thioureas

Author(s): Adriana Marques Moraes, Tiago Lima da Silva and Marcio C.S. de Mattos*

Volume 27, Issue 15, 2023

Published on: 04 October, 2023

Page: [1319 - 1328] Pages: 10

DOI: 10.2174/0113852728263929230919074722

Price: $65

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Abstract

Tetrazoles are important heterocycles in diverse branches of chemistry. Among the 5-substituted tetrazoles, the 5-amino derivatives are the most important by far as they show high chemical versatility and relevant applications in material chemistry, catalysis, agrochemistry, etc. Particularly in medicinal chemistry, they present a wide range of pharmacological properties. In the present review, we focus on the synthesis of 5- aminotetrazol from the desulfurization processes of thioureas using metal salts, hypervalent iodine compounds and halogenated reagents.

Keywords: Organic synthesis, azidation, carbodiimide, oxidation, isothiourea, guanyl azide.

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