Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Research Article

Ginger’s Antiapoptotic and Antioxidant Effects on Ovaries of Cyclophosphamide-therapied Rats

Author(s): Maryamsadat Shahidi, Omid Abazari, Parisa Dayati, Bibi Fatemeh Haghiralsadat, Fatemeh Oroojalian*, Javad Zavar Reza* and Seyed Morteza Naghib*

Volume 29, Issue 28, 2023

Published on: 04 October, 2023

Page: [2264 - 2275] Pages: 12

DOI: 10.2174/0113816128263943230920093609

Price: $65

conference banner
Abstract

Background: In the recent decade, there has been increasing interest in preventing ovarian toxicity after chemotherapy exposure. It has been documented that ginger (Zingiber officinale) might normalize the hormonal balance and control the menstrual cycle..

Objective: This study has analyzed whether ginger extract protects against cyclophosphamide (CP)-induced ovarian failure in rats.

Methods: Rats were distributed into four groups consisting of vehicle, CP, ginger, and CP + ginger. At the end of the treatment, all rats were killed under anesthesia to obtain ovarian tissues and blood samples for histological, molecular, and biochemical experiments.

Results: Our results indicated that ginger improves CP-caused histological changes in ovarian tissues and significantly restores serum hormonal abnormalities. Ginger also showed unique antioxidant, anti-inflammatory, and antiapoptotic properties in the ovarian tissues of CP-induced rats. Further, our findings indicated that ginger might activate the Nrf2 and SIRT and inhibit the PI3K/AKT pathway in the ovaries of CP-treated rats. In conclusion, ginger was found to protect against CP-caused ovarian toxicity in rats.

Conclusion: The protective impacts of ginger may mediate, at least partly, by alleviating the oxidant state, inhibiting pro-inflammatory conditions, and exhibiting antiapoptotic activities.

Keywords: Ginger, cyclophosphamide, ovary, oxidative stress, inflammation, apoptosis.

« Previous

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy