Title:Therapeutic and Safety Promise of Mesenchymal Stem Cells for Liver Failure: From Preclinical Experiment to Clinical Application
Volume: 19
Issue: 10
Author(s): Qiong Xie and Jundong Gu*
Affiliation:
- National Engineering Research Center of Cell Products, AmCellGene Engineering Co., Ltd, Tianjin, 300457, China
Keywords:
Mesenchymal stem cells, liver failure, cell therapy, clinical trial, immune regulation, clinical application.
Abstract: Liver failure (LF) is serious liver damage caused by multiple factors, resulting in severe
impairment or decompensation of liver synthesis, detoxification, metabolism, and biotransformation.
The general prognosis of LF is poor with high mortality in non-transplant patients. The clinical
treatments for LF are mainly internal medicine comprehensive care, artificial liver support system,
and liver transplantation. However, none of the above treatment strategies can solve the problems of
all liver failure patients and has its own limitations. Mesenchymal stem cells (MSCs) are a kind of
stem cells with multidirectional differentiation potential and paracrine function, which play an important
role in immune regulation and tissue regeneration. In recent years, MSCs have shown multiple
advantages in the treatment of LF in pre-clinical experiments and clinical trials. In this work, we
reviewed the biological characteristics of MSCs, the possible molecular mechanisms of MSCs in the
treatment of liver failure, animal experiments, and clinical application, and also discussed the existing
problems of MSCs in the treatment of liver failure.