Title:Lysosomal Storage Diseases: Natural Products Inducing Autophagy
Volume: 19
Issue: 5
Author(s): Chandani Chandarana*, Tahib Habshi, Arun Soni and Sanjeev Acharya
Affiliation:
- Department of Quality Assurance, SSR College of Pharmacy, Sayli Road, Silvassa, U.T of Dadra Nagar and Haveli,
396230, India
Keywords:
Autophagy, lysosomal function, lysosomal storage disorder, transcriptional factor EB, mammalian target for rapamycin, natural autophagy inducers.
Abstract:
Background: The link between autophagy and lysosomal function has been wellrecognised
in recent decades; defective autophagy and lysosomal function lead to various disorders,
notably Lysosomal Storage Disorders (LSDs). The malfunction of multiple mechanistic pathways influences
the contribution of LSDs. Different ways are employed in such situations, but one novel approach
could resolve the problem by inducing the autophagic pathway, which aids in maintaining
proper autophagy and lysosomal degradation function.
Methods: Autophagic Inducer functions on the activation of Transcriptional factor EB (TFEB) and its
mechanism; mTOR Complex Inhibition dependently or independently may repair the malfunction of
the entire mechanism. Finding a potential autophagic inducer is still a work in progress, but targeting
TFEB and mTOR could redefine LSD treatment. The development of experimentally available TFEB
modulators could enhance autophagic flux promote lysosomal function and increase lysosomal biogenesis
and can be a promising technique for treating illnesses caused by ALP dysfunction, such as
lysosomal storage disorder.
Results: MTORC1 suppression causes TFEB to be transported to the nucleus and transcription of multiple
genes involved in the formation of autophagosomes and lysosomes, indicating that MTORC1 has
positive effects in treating lysosomal storage diseases such as Pompe disease, Batton disease, Fabry
disease, etc. thus modulating autophagy attenuates the above condition.
Conclusion: This review comprises autophagy and lysosome association, and their malfunction leads
to various lysosomal diseases. Several natural products are also discussed, which can be possible
treatment options.
