Title:Differential Diagnosis or Etiology: A Case Report on Amyotrophic Lateral Sclerosis-like Neuropathy Associated with HIV Infection
Volume: 21
Issue: 5
Author(s): Renato Barradas Rodrigues*, Marco Orsini, Sofia Vieira Neves, Wladimir Bocca Vieira de Rezende Pinto, Antônio Marcos da Silva Catarino, Daniel Antunes Pereira and Acary Souza Bulle Oliveira
Affiliation:
- Department of Neurosurgery, Fluminense Federal University, Brazil
Keywords:
Motor neuron disease, amyotrophic lateral sclerosis, HIV, anti-retroviral agents, riluzole, edaravone, DNA transposable elements, retroelements.
Abstract:
Background: Retroviruses are described as a risk factor for chronic neuropathy. However,
it is still unknown if they can work as amyotrophic lateral sclerosis triggers. Over the years,
some cases of this association have been described with heterogenous disclosures.
Case Representation: This study aimed to report a case of HIV and ALS-like neuropathy and briefly
discuss peculiarities of clinical aspects, such as physiopathology and treatment options. The patient
underwent neurological examination associated with blood tests, electromyography, analysis
of cerebrospinal fluid, and imaging studies.
Discussion: A non-systematic review was performed in major databases regarding the topic. The
case presented mixed upper and lower motor neuron signs and was framed as a probable case of
ALS following the present criteria.
Conclusion: After a short follow-up and viral load cleansing, neurological stabilization was
achieved.
