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Current Pharmaceutical Analysis

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ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

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Review Article

Analytical Methodologies for the Estimation of Acyclovir as Key Members of Anti-viral Agent: Two Decades in Review

Author(s): Akhil Gupta and Shilpi Pathak*

Volume 19, Issue 8, 2023

Published on: 15 September, 2023

Page: [597 - 609] Pages: 13

DOI: 10.2174/1573412919666230908161943

Price: $65

Abstract

Herpes simplex virus (HSV) is a viral infection that primarily targets oral and genital organs in humans. Acyclovir is a widely prescribed anti-viral agent used in the infection caused by herpes simplex virus (HSV). This article emphasizes several analytical techniques, including spectrophotometry, High-performance liquid chromatography, High-performance thin-layer liquid chromatography, Ultra performance liquid chromatography, and Liquid chromatography/ Mass detection for the quantification of acyclovir in different matrices like biological fluids and Pharmaceutical formulation. In the proposed work, numerous methods for different techniques were extracted from various databases such as Science Direct, Springer, PubMed, SCOPUS, Web of Science, etc. According to the recommendation from the internal conference on harmonization, this review describes how to determine the presence of utilizing acyclovir in different analytical techniques alone or in combination with another drug.

Keywords: Acyclovir, anti-viral drug, HPLC, UPLC, HPTLC, LC/MS, spectrophotometry.

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Graphical Abstract

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