Title:Extracellular Vesicles from Stromal Vascular Fraction of Human Adipose
Tissue in the Development of Non-antibiotic Therapy
Volume: 24
Issue: 12
Author(s): V.M.H. Srinivasa, B.M. Kumar, Prakash Patil, Nikhil Shetty and A.V. Shetty*
Affiliation:
- Microbiology/Nitte University Centre for Stem Cell Research and Regenerative Medicine (NUCSReM)/Central Research
Laboratory, K S Hegde Medical Academy, NITTE (Deemed to be University), Mangaluru-575018, India
Keywords:
Antimicrobial extracellular vesicles, human adipose tissue, stromal vascular fraction, immunomodulation, Antibiotic- resistant microbes, TNF-alpha.
Abstract:
Background: Antibiotic-resistant microorganisms (ARMS) are the leading cause of socio-
economic loss in the world, with historical evidence linking them to increased mortality and
morbidity.
Methodology: In this systematic review, we highlight a new treatment approach for antibiotic-resistant
infections using 'Extracellular vesicle (EVs)-based therapy,' also known as cell- and drug-free
therapy. Here, we categorize and summarize studies on EVs derived from various human sources,
such as tissues, bodily fluids, or their condition media, emphasizing their anti-infective properties
in the treatment of various infections. In addition, we contend that human adipose tissue (HAT) is a
superior source of antimicrobial EVs (aEVs) and investigate the distinct antimicrobial properties of
aEVs derived from a stromal vascular fraction (SVF) of human adipose tissue. In light of this, we
described the limited literature and research gaps that are essential for using SVF-aEVs as personalized
precision medicine.
Result and Discussion: The notion behind adipose-derived SVF-EVs is supported by extensive literature
searches that demonstrate growing trends in EV-based medical treatments as well as the
larger therapeutic potential of HAT because of its extensive history of usage in regenerative
medicine.
Conclusion: Additionally, the underlying science that explains how the inflammatory process aids
in the clearance of infections and the restoration of homeostasis after the host immune system successfully
defends against foreign pathogens, as well as the fact that adipose-derived SVF is a noninvasive,
cost-effective source of a variety of parent immune cells that produces a good yield of
EVs with the same genetic make-up as their parent cells, make this concept worthwhile. This research
may thereby increase survival rates and survival quality in cases of resistant infections.
Vocabulary: Drug- and cell-free therapy = Nano molecules (extracellular vesicles) used as a therapeutic
source without the need for chemical drugs or cell transplantation. Anti-infection EVs
(aEVs) = Nature’s own anti-infection powered EVs (unmodified).
