Title:Pegylated Nanoparticles for Brain Targeting- Opportunities and Challenges
Volume: 13
Issue: 3
Author(s): Utsav Gupta*Shaheen Sultana
Affiliation:
- Department of Pharmacy, IIMT College of Pharmacy, Plot No. 20, Knowledge Park III, Greater Noida, Uttar Pradesh,
201310, India
Keywords:
PEGylated nanoparticles, Liposomes, BBB, Brain disorders, Alzheimer’s, targeted delivery.
Abstract: As the blood-brain barrier (BBB) stops hazardous substances from entering the brain,
creating treatment strategies to treat central nervous system (CNS) conditions is difficult. By circumventing
the BBB, nanotechnology has emerged as a viable method for targeted medicine delivery
to the brain. PEGylated nanoparticles (PEGNPs) have shown the ability to encapsulate a range
of drugs and deliver them to the deepest regions of the brain. PEGNPs are a helpful tool in preclinical
research for CNS diseases because of their extreme flexibility. Before PEGNPs can be employed
in clinical practise, however, issues with their design and optimization for efficient brain targeting,
as well as their long-term safety, must be resolved. Moreover, it is crucial to comprehend the basic
principles of PEGNP trafficking through the BBB and how they affect CNS cells. Despite these difficulties,
PEGNPs have the potential to completely alter the way CNS diseases are treated by allowing
for precise medication delivery to the brain. This review emphasizes the potential and difficulties
in using PEGNPs for brain targeting and describes current breakthroughs in PEGNP research
for CNS diseases.
