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Mini-Reviews in Medicinal Chemistry

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ISSN (Online): 1875-5607

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Mini-Review Article

The Critical Function of microRNAs in Developing Resistance against 5- Fluorouracil in Cancer Cells

Author(s): Farhad Sheikhnia, Hossein Maghsoudi and Maryam Majidinia*

Volume 24, Issue 6, 2024

Published on: 25 September, 2023

Page: [601 - 617] Pages: 17

DOI: 10.2174/1389557523666230825144150

Price: $65

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Abstract

Although there have been significant advancements in cancer treatment, resistance and recurrence in patients make it one of the leading causes of death worldwide. 5-fluorouracil (5-FU), an antimetabolite agent, is widely used in treating a broad range of human malignancies. The cytotoxic effects of 5-FU are mediated by the inhibition of thymidylate synthase (TYMS/TS), resulting in the suppression of essential biosynthetic activity, as well as the misincorporation of its metabolites into RNA and DNA. Despite its huge benefits in cancer therapy, the application of 5-FU in the clinic is restricted due to the occurrence of drug resistance. MicroRNAs (miRNAs) are small, non-coding RNAs that act as negative regulators in many gene expression processes. Research has shown that changes in miRNA play a role in cancer progression and drug resistance. This review examines the role of miRNAs in 5-FU drug resistance in cancers.

Keywords: 5-FU, Drug resistance, miRNAs, chemosensitivity, apoptosis, cancer treatment.

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