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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Mini-Review Article

Traditional Uses, Phytochemical Constituents and Ethnopharmacological Properties of Mistletoe from Phoradendron and Viscum Species

Author(s): Luis Aurelio Montoya-Inzunza, J. Basilio Heredia, Jayanta Kumar Patra, Sushanto Gouda, Rout George Kerry, Gitishree Das and Erick Paul Gutierrez-Grijalva*

Volume 27, Issue 8, 2024

Published on: 11 September, 2023

Page: [1093 - 1110] Pages: 18

DOI: 10.2174/1386207326666230825113631

Price: $65

Abstract

Plants from the genus Phoradendron and Viscum, also known as American and European mistletoe, are a group of hemiparasitic plants traditionally used to treat many diseases. Mistletoes have a rich content of natural compounds like terpenes, alkaloids, proteins, and phenolic compounds associated with their potential medicinal properties. In this sense, mistletoes have shown antiproliferative, antioxidant, anti-inflammatory, and antimicrobial activity, which has been attributed to their phytochemical constituents. The mechanisms in which mistletoe plants act vary and depend on their phytochemical content and distribution, which in part will depend on the mistletoe species. In this sense, recent literature research is needed to visualize state of the art in the ethnopharmacological potential of mistletoe. Thus, this literature review aims to systematically report recent studies (2010-2023) on the phytochemical characterization and bioactive studies of mistletoe plants, mainly the Viscum and Phoradendron genera. We gather recent information of 140 references selected in our research. Here we report that although there are several bioactivity studies of mistletoe species, bioavailability studies are still scarce, and the precise mechanisms of action are not fully known. We encourage that further studies include a systematic strategy to cover these areas of opportunity.

Keywords: Mistletoe, medicinal plants, phytochemicals, polyphenols, phoradendron, viscum.

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Graphical Abstract

[1]
Nickrent, D.L. Santalales (Including Mistletoes). Encyclopedia of Life Sciences; Wiley: Hoboken, 2011.
[2]
Nickrent, D.L.; Malécot, V.; Vidal-Russell, R.; Der, J.P. A revised classification of Santalales. Taxon, 2010, 59(2), 538-558.
[http://dx.doi.org/10.1002/tax.592019]
[3]
Lara-Ponce, E.; Quintero-Romanillo, A.L. Plantas Medicinales del Norte de Sinaloa. 2016. Available from: https://docplayer.es/70472929-Plantas-medicinales-del-norte-desinaloa.html
[4]
Adesina, S.K.; Illoh, H.C.; Johnny, I.I.; Jacobs, I.E. African mistletoes (loranthaceae); ethnopharmacology, chemistry and medicinal values: An update. Afr. J. Tradit. Complement. Altern. Med., 2013, 10(4), 161-170.
[http://dx.doi.org/10.4314/ajtcam.v10i4.26] [PMID: 24146518]
[5]
Evans, M.; Bryant, S.; Huntley, A.L.; Feder, G. Cancer patients’ experiences of using mistletoe (Viscum album): A qualitative systematic review and synthesis. J. Altern. Complement. Med., 2016, 22(2), 134-144.
[http://dx.doi.org/10.1089/acm.2015.0194] [PMID: 26684278]
[6]
Szurpnicka, A.; Kowalczuk, A.; Szterk, A. Biological activity of mistletoe: In vitro and in vivo studies and mechanisms of action. Arch. Pharm. Res., 2020, 43(6), 593-629.
[http://dx.doi.org/10.1007/s12272-020-01247-w] [PMID: 32621089]
[7]
Tsekouras, V.; Kintzios, S. Biotechnology of Viscum Album L. and Cancer Treatment: A Review. Curr. Bioact. Compd., 2020, 16(6), 738-746.
[http://dx.doi.org/10.2174/1573407215666190410151958]
[8]
Loef, M.; Walach, H. Quality of life in cancer patients treated with mistletoe: A systematic review and meta-analysis. BMC Complementary Med. Therap., 2020, 20(1), 227.
[http://dx.doi.org/10.1186/s12906-020-03013-3] [PMID: 32690087]
[9]
García-García, J.D.; Anguiano-Cabello, J.C.; Arredondo-Valdés, R.; Candido del Toro, C.A.; Martínez-Hernández, J.L.; Segura-Ceniceros, E.P.; Govea-Salas, M.; González-Chávez, M.L.; Ramos-González, R.; Esparza-González, S.C.; Ascacio-Valdés, J.A.; López-Badillo, C.M.; Ilyina, A. Phytochemical characterization of Phoradendron bollanum and Viscum album subs. austriacum as Mexican mistletoe plants with antimicrobial activity. Plants, 2021, 10(7), 1299.
[http://dx.doi.org/10.3390/plants10071299] [PMID: 34206859]
[10]
Vasconcellos, C.L.C.; Vitório, K.C.D.; Andrade, P.A.; Cambuí, É.V.F.; Lira, A.F.; Cavalcante, S.C.H.; Estevam, C.S.; Antoniolli, Â.R.; Thomazzi, S.M. Antinociceptive, anti-inflammatory, and antioxidant properties of Phoradendron piperoides leaves. Pharm. Biol., 2009, 47(7), 645-652.
[http://dx.doi.org/10.1080/13880200902917065]
[11]
Bar-Sela, G. White-Berry Mistletoe (Viscum album L.) as complementary treatment in cancer: Does it help? Eur. J. Integr. Med., 2011, 3(2), e55-e62.
[http://dx.doi.org/10.1016/j.eujim.2011.03.002]
[12]
Kienle, G.S.; Kiene, H. Review article: Influence of Viscum album L (European mistletoe) extracts on quality of life in cancer patients: A systematic review of controlled clinical studies. Integr. Cancer Ther., 2010, 9(2), 142-157.
[http://dx.doi.org/10.1177/1534735410369673] [PMID: 20483874]
[13]
Mavrikou, S.; Tsekouras, V.; Karageorgou, M.A.; Moschopoulou, G.; Kintzios, S. Anticancer and biochemical effects of Viscum album L. protein extracts on HeLa cells. Plant Cell Tissue Organ Cult., 2020, 140(2), 369-378.
[http://dx.doi.org/10.1007/s11240-019-01733-0]
[14]
Marvibaigi, M.; Supriyanto, E.; Amini, N.; Abdul Majid, F.A.; Jaganathan, S.K. Preclinical and clinical effects of mistletoe against breast cancer. BioMed Res. Int., 2014, 2014, 1-15.
[http://dx.doi.org/10.1155/2014/785479] [PMID: 25136622]
[15]
Lev, E.; Ephraim, M.; Ben-Arye, E. European and Oriental mistletoe: From mythology to contemporary integrative cancer care. Eur. J. Integr. Med., 2011, 3(3), e133-e137.
[http://dx.doi.org/10.1016/j.eujim.2011.05.052]
[16]
Freuding, M.; Keinki, C.; Micke, O.; Buentzel, J.; Huebner, J. Mistletoe in oncological treatment: A systematic review. J. Cancer Res. Clin. Oncol., 2019, 145(3), 695-707.
[http://dx.doi.org/10.1007/s00432-018-02837-4] [PMID: 30673873]
[17]
Matthes, H.; Thronicke, A.; Hofheinz, R.D.; Baars, E.; Martin, D.; Huber, R.; Breitkreuz, T.; Bar-Sela, G.; Galun, D.; Schad, F. Statement to an Insufficient Systematic Review on Viscum album L. Therapy. Evid. Based Complement. Alternat. Med., 2020, 2020, 1-9.
[http://dx.doi.org/10.1155/2020/7091039] [PMID: 32148549]
[18]
Valencia-Chan, L.S.; García-Cámara, I.; Torres-Tapia, L.W.; Moo-Puc, R.E.; Peraza-Sánchez, S.R. Lupane-Type Triterpenes of Phoradendron vernicosum. J. Nat. Prod., 2017, 80(11), 3038-3042.
[http://dx.doi.org/10.1021/acs.jnatprod.7b00177] [PMID: 29120172]
[19]
Jiménez-Estrada, M.; Velázquez-Contreras, C.; Garibay-Escobar, A.; Sierras-Canchola, D.; Lapizco-Vázquez, R.; Ortiz-Sandoval, C.; Burgos-Hernández, A.; Robles-Zepeda, R.E. In vitro antioxidant and antiproliferative activities of plants of the ethnopharmacopeia from northwest of Mexico. BMC Complement. Altern. Med., 2013, 13(1), 12.
[http://dx.doi.org/10.1186/1472-6882-13-12] [PMID: 23305162]
[20]
Varela, B.G.; Fernández, T.; Ricco, R.A.; Zolezzi, P.C.; Hajos, S.E.; Gurni, A.A.; Alvarez, E.; Wagner, M.L. Phoradendron liga (Gill. ex H. et A.) Eichl. (Viscaceae) used in folk medicine: Anatomical, phytochemical, and immunochemical studies. J. Ethnopharmacol., 2004, 94(1), 109-116.
[http://dx.doi.org/10.1016/j.jep.2004.04.027] [PMID: 15261970]
[21]
Alonso-Castro, A.J.; Juárez-Vázquez, M.C.; Domínguez, F.; González-Sánchez, I.; Estrada-Castillón, E.; López-Toledo, G.; Chávez, M.; Cerbón, M.A.; García-Carranca, A. The antitumoral effect of the American mistletoe Phoradendron serotinum (Raf.) M.C. Johnst. (Viscaceae) is associated with the release of immunityrelated cytokines. J. Ethnopharmacol., 2012, 142(3), 857-864.
[http://dx.doi.org/10.1016/j.jep.2012.06.018] [PMID: 22732726]
[22]
Cavalcante Guimarães, A.; Jesus Silva, C. d.; Antonio Carlos Siani, A. Etnobotânica de espécies de erva-de-passarinho ou visco (famílias Loranthaceae e Viscaceae). Rev. fitoter, 2013, 13(2), 137-152.
[23]
Bastos, I.G.A.; Oliveira, T.B.D.; Rodrigues, M.D.; Militão, G.C.G.; Silva, T.G.D.; Turatti, I.C.C.; Lopes, N.P.; Melo, S.J.D. Use of GC/MS to identify chemical constituents and cytotoxic activity of the leaves of Phoradendron mucronatum and Phoradendron microphyllum (Viscaceae). An. Acad. Bras. Cienc., 2017, 89(2), 991-1001.
[http://dx.doi.org/10.1590/0001-3765201720160586] [PMID: 28640349]
[24]
Rios, M.Y.; Salinas, D.; Villarreal, M.L. Cytotoxic activity of moronic acid and identification of the new triterpene 3,4-secoolean-18-ene-3,28-dioic acid from Phoradendron reichenbachianum. Planta Med., 2001, 67(5), 443-446.
[http://dx.doi.org/10.1055/s-2001-15823] [PMID: 11488459]
[25]
Gupta, G.; Kazmi, I.; Afzal, M.; Rahman, M.; Saleem, S.; Ashraf, M.S.; Khusroo, M.J.; Nazeer, K.; Ahmed, S.; Mujeeb, M.; Ahmed, Z.; Anwar, F. Sedative, antiepileptic and antipsychotic effects of Viscum album L. (Loranthaceae) in mice and rats. J. Ethnopharmacol., 2012, 141(3), 810-816.
[http://dx.doi.org/10.1016/j.jep.2012.03.013] [PMID: 22449438]
[26]
Owczarek, K. Treating epilepsy: A review of Polish historical sources. Epilepsy Behav., 2011, 22(2), 226-230.
[http://dx.doi.org/10.1016/j.yebeh.2011.05.021] [PMID: 21775214]
[27]
Yao, H.; Zhou, G.X.; Wu, Q.; Lei, G.Q.; Chen, D.F.; Chen, J.K.; Zhou, T.S. Mistletonone, a novel antioxidative diarylheptanoid from the branches and leaves of Viscum coloratum. Molecules, 2007, 12(3), 312-317.
[http://dx.doi.org/10.3390/12030312] [PMID: 17851390]
[28]
Sabová, L.; Pilátová, M.; Szilagyi, K.; Sabo, R.; Mojžiš, J. Cytotoxic effect of mistletoe (Viscum album L.) extract on Jurkat cells and its interaction with doxorubicin. Phytother. Res., 2010, 24(3), 365-368.
[http://dx.doi.org/10.1002/ptr.2947] [PMID: 19610041]
[29]
Kuo, Y.J.; Yang, Y.C.; Zhang, L.J.; Wu, M.D.; Kuo, L.M.Y.; Kuo, Y.C.; Hwang, S.Y.; Chou, C.J.; Lee, K.H.; Ho, H.O.; Kuo, Y.H. Flavanone and diphenylpropane glycosides and glycosidic acyl esters from Viscum articulatum. J. Nat. Prod., 2010, 73(2), 109-114.
[http://dx.doi.org/10.1021/np9004294] [PMID: 20121165]
[30]
Stefanucci, A.; Zengin, G.; Llorent-Martinez, E.J.; Dimmito, M.P.; Della Valle, A.; Pieretti, S.; Ak, G.; Sinan, K.I.; Mollica, A. Viscum album L. homogenizer-assisted and ultrasound-assisted extracts as potential sources of bioactive compounds. J. Food Biochem., 2020, 44(9), e13377.
[31]
Clark, N.F.; McComb, J.A.; Taylor-Robinson, A.W. Host species of mistletoes (Loranthaceae and Viscaceae) in Australia. Aust. J. Bot., 2020, 68(1), 1-13.
[http://dx.doi.org/10.1071/BT19137]
[32]
Elsyana, V.; Bintang, M.; Priosoeryanto, B.P. Cytotoxicity and antiproliferative activity assay of clove mistletoe (Dendrophthoe pentandra (L.) Miq.) leaves extracts. Adv. Pharmacol. Sci., 2016, 2016, 3242698.
[33]
Hong, X.; Mat Isa, N.; Fakurazi, S.; Safinar Ismail, I. Phytochemical and anti‐inflammatory properties of Scurrula ferruginea (Jack) Danser parasitising on three different host plants elucidated by NMR‐based metabolomics. Phytochem. Anal., 2020, 31(1), 15-27.
[http://dx.doi.org/10.1002/pca.2861] [PMID: 31243835]
[34]
Priya, U.; Neelamegam, R. Phytochemical and antimicrobial evaluation of a hemiparasitic mistletoe plant, Dendrophthoe falcata (LF) Ettingsh, parasitize on Artocarpus heterophyllus host tree. J. Med. Plants, 2016, 4(5), 01-07.
[35]
Wiart, C. Medicinal Plants of China, Korea, and Japan; Taylor & Francis: London, 2012.
[http://dx.doi.org/10.1201/b12046]
[36]
Builder, M.I.; Joseph, S.O.; Olugbemi, T.O.; Akande, T. Toxicity studies of extract of African Mistletoe: Agelanthus Dodoneifolius Polh and Wiens in rats. Niger. Biomed. Sci. J., 2020, 17(1), 8-12.
[37]
Isikhuemen, E.M.; Olisaemeka, U.O.; Oyibotie, G.O. Host specificity and phytochemical constituents of mistletoe and twigs of parasitized plants: Implications for blanket application of mistletoe as cure-all medicine. J. Med. Herbs Ethnomedi., 2020, 6, 30-37.
[http://dx.doi.org/10.25081/jmhe.2020.v6.5686]
[38]
Olakanmi Bodun, O.; Olorundare Olufunke, E.; Afolabi Olanrewaju, O.; Anoka, N.; Olugbenga, A.; Akanbi Olatunde, A. Assessment of the Effects of Crude Methanolic Extracts (Leaf and Twig) of Loranthus micranthus on Streptozotocin Induced Diabetic Rats. JDIB, 2020, 10, 2641-8975.
[39]
Ogunmefun, O.T.; Fasola, T.R.; Saba, A.B.; Oridupa, O.A. The ethnobotanical, phytochemical and mineral analyses of phragmanthera incana (klotzsch), a species of mistletoe growing on three plant hosts in South-Western Nigeria. Int. J. Biomed. Sci., 2013, 9(1), 33-40.
[PMID: 23675287]
[40]
Furlan, C.M.; Anselmo-Moreira, F.; Teixeira-Costa, L.; Ceccantini, G.; Salminen, J.P. Does Phoradendron perrottetii (mistletoe) alter polyphenols levels of Tapirira guianensis (host plant)? Plant Physiol. Biochem., 2019, 136, 222-229.
[http://dx.doi.org/10.1016/j.plaphy.2019.01.025] [PMID: 30703634]
[41]
Amico, G.C.; Nickrent, D.L. First Report of the Mistletoe Tristerix verticillatus on Schinus fasciculatus from the Sierra de San Luis, Argentina. Plant Dis., 2009, 93(3), 317-317.
[http://dx.doi.org/10.1094/PDIS-93-3-0317A] [PMID: 30764211]
[42]
Coder, K.D. American mistletoe: Kissing under a parasite. Arboric. J., 2004, 13, 37-44.
[43]
Simirgiotis, M.; Quispe, C.; Areche, C.; Sepúlveda, B. Phenolic compounds in chilean mistletoe (Quintral, Tristerix tetrandus) analyzed by UHPLC–Q/Orbitrap/MS/MS and its antioxidant properties. Molecules, 2016, 21(3), 245.
[http://dx.doi.org/10.3390/molecules21030245] [PMID: 26907248]
[44]
Mallams, K.M.; Mathiasen, R.L. Mistletoe on Hardwoods in the United States 2010. Available from: https://www.fs.usda.gov/Internet/FSE_DOCUMENTS/fsbdev2_025934.pdf
[45]
Gelis, B.W.; Tovar, C.; Moody, J.B. Mistletoes of North American Conifers. 2002. Available from: https://www.fs.usda.gov/research/treesearch/4812
[46]
Zuber, D.; Widmer, A. Genetic evidence for host specificity in the hemi-parasitic Viscum album L. (Viscaceae). Mol. Ecol., 2000, 9(8), 1069-1073.
[http://dx.doi.org/10.1046/j.1365-294x.2000.00963.x] [PMID: 10964226]
[47]
Lech, P.; Żółciak, A.; Hildebrand, R. Occurrence of European mistletoe (Viscum album L.) on forest trees in Poland and its dynamics of spread in the period 2008–2018. Forests, 2020, 11(1), 83.
[http://dx.doi.org/10.3390/f11010083]
[48]
Park, B-J.; Matsuta, T.; Samejima, H.; Park, C-H.; Sung, I.J.; Lee, B-D.; Onjo, M. Chemical Constituents of Mistletoe (Viscum album L. var. coloratum Ohwi). IOSR J. Pharm. Biol. Sci., 2017, 12, 19-23.
[49]
Soursouri, A.; Hosseini, S.M.; Fattahi, F. Biochemical analysis of European mistletoe (Viscum album L.) foliage and fruit settled on Persian ironwood (Parrotia persica C. A. Mey.) and hornbeam (Carpinus betulus L.). Biocatal. Agric. Biotechnol., 2019, 22101360.
[http://dx.doi.org/10.1016/j.bcab.2019.101360]
[50]
Torres, P.; Saldaña, C.; Ortega, R.; González, C. Determination of reducing power and phytochemical profile of the chilean mistletoe “quintral” (Tristerix corymbosus (L) Kuijt) hosted in “Maqui” (Aristotelia chilensis), “Huayún” (Rhaphitamnus spinosus) AND “POPLAR” (Populus nigra). J. Chil. Chem. Soc., 2019, 64(4), 4645-4650.
[http://dx.doi.org/10.4067/S0717-97072019000404645]
[51]
Tsekouras, V.; Mavrikou, S.; Vlachakis, D.; Makridakis, M.; Stroggilos, R.; Zoidakis, J.; Termentzi, A.; Moschopoulou, G.; Kintzios, S. Proteome analysis of leaf, stem and callus in Viscum album and identification of lectins and viscotoxins with bioactive properties. Plant Cell Tissue Organ Cult., 2020, 141(1), 167-178.
[http://dx.doi.org/10.1007/s11240-020-01777-7]
[52]
Catalán, P.; Aparicio, A. Viscum L.Flora ibérica: Haloragaceae-Euphorbiaceae; Castroviejo, S., Ed.; Editorial CSIC-CSIC Press: Madrid, 1997, Vol. 8, pp. 160-164.
[53]
Min Young, K. (Korthalsella japonica) extracts. Asian J. Pharm. Clin. Res., 2017, 10(12)
[54]
Meena, K.; Kanti, S.; Rajani, M. Study on phytochemical, antibacterial, antioxidant and toxicity profile of viscum album linn associated with acacia catechu. Nepal J. Biotechnol., 2015, 3(1), 60.
[55]
Isikhuemen, E.M.; Olisaemeka, U.O.; Oyibotie, G.O. Host specificity and phytochemical constituents of mistletoe and twigs of parasitized plants: Implications for blanket application of mistletoe as cure-all medicine. J. Med. Herbs. Ethnomed., 2020, 6, 6.
[56]
Ferrenberg, S. Dwarf mistletoe infection interacts with tree growth rate to produce opposing direct and indirect effects on resin duct defenses in lodgepole pine. Forests, 2020, 11(2), 222.
[http://dx.doi.org/10.3390/f11020222]
[57]
Polhill, R.; Wiens, D. Mistletoes of Africa; Royal Botanic Gardens: Kew, 2000.
[58]
Abdul Wahid, H.; Barozai, M.Y.K.; Din, M. Dwarf mistletoe (Arceuthobium oxycedri) and damage caused by dwarf mistletoe to family Cupressaceae. Pure Appl. Biol., 2015, 4(1), 15-23.
[http://dx.doi.org/10.19045/bspab.2015.41003]
[59]
Erdogan Orhan, I.; Küpeli Akkol, E.; Suntar, I.; Yesilada, E. Assessment of anticholinesterase and antioxidant properties of the extracts and (+)-catechin obtained from Arceuthobium oxycedri (D.C.) M. Bieb (dwarf mistletoe). S. Afr. J. Bot., 2019, 120, 309-312.
[http://dx.doi.org/10.1016/j.sajb.2018.09.023]
[60]
Calkins, S.J.; Shaw, D.C.; Lan, Y.H. Transformation of western hemlock (Tsuga heterophylla) tree crowns by dwarf mistletoe (Arceuthobium tsugense, Viscaceae). For. Pathol., 2021, 51(1)
[http://dx.doi.org/10.1111/efp.12664]
[61]
David, S.R.; Lim, Y.C.; Rajabalaya, R. A hidden treasure: The borneo mistletoes. Pharmacogn. Rev., 2017, 11(22), 153-157.
[http://dx.doi.org/10.4103/phrev.phrev_16_17] [PMID: 28989251]
[62]
Bonamin, L.V.; de Carvalho, A.C.; Waisse, S. Viscum album (L.) in experimental animal tumors: A meta-analysis. Exp. Ther. Med., 2017, 13(6), 2723-2740.
[http://dx.doi.org/10.3892/etm.2017.4372] [PMID: 28596809]
[63]
Wasagwa, J.; Lawan, B.B.; Abdullahi, B.A.; Joshua, L.; Saidu, N.I.; God, O.E. Phytochemistry and Toxicity Studies on Aqueous Extracts of Leaf and Stem of Mistletoe (Viscum album) in Albino Rats. Int J. Homeopath. Nat. Med., 2018, 4(1), 1-5.
[64]
Patel, S.; Gupta, G.K. 7. Mistletoe lectin: A promising cancer therapeutic.Chemical Drug Design; De Gruyter: Berlin, 2016, pp. 165-182.
[http://dx.doi.org/10.1515/9783110368826-009]
[65]
Alharits, L.; Handayani, W.; Yasman,; Hemelda, N.M. Yasman; Hemelda, N. M., Phytochemical analysis and antioxidant activity of leaves and flowers extracts of mistletoe (Dendrophthoe pentandra (L.) Miq.), collected from UI Campus, Depok. AIP Conf. Proc., 2019, 2168(1), 020101.
[http://dx.doi.org/10.1063/1.5132528]
[66]
Inusa, A.; Sanusi, S.B.; Linatoc, A.C.; Mainassara, M.M.; Ibrahim, M.A.J.S.W.J. Phytochemical and antibacterial screening of mistletoe (Agelanthus dodoniesfolius (DC)) collected from shea butter tree (Vitelleria paradoxa). ScientificWorldJournal, 2018, 13(3), 33-36.
[67]
Njoya, H.; Chukwu, E.; Okwuonu, C.; Erifeta, G. Phytochemical, proximate and elemental analysis of the African mistletoe (Tapinanthus preussii) crude aqueous and ethanolic leaf extracts. Faslnamah-i Giyahan-i Daruyi, 2018, 6(6), 162-170.
[68]
Umarudeen, A.M.; Chika, A. Phytochemical, elemental and in-vitro anti-oxidant activity screening of crude methanol Tapinanthus globiferus leaf extract. Int. Arch. Med. Sci., 2019, 1(3), 162-170.
[69]
Resmi, M.; Dudi, R.; Danni, R. The Antioxidant Activity and Phytochemical Screening of Ethanol Extract, Fractions of Water, Ethyl Acetate and n-Hexane from Mistletoe Tea (Scurrula atropurpureabl. Asian J. Pharm. Clin. Res., 2017, 10(2)
[70]
Amer, B.; Juvik, O.J.; Dupont, F.; Francis, G.W.; Fossen, T. Novel aminoalkaloids from European mistletoe (Viscum album L.). Phytochem. Lett., 2012, 5(3), 677-681.
[http://dx.doi.org/10.1016/j.phytol.2012.07.005]
[71]
National Center for Biotechnology Information. Isopteropodine. 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Isopteropodine
[72]
National Center for Biotechnology Information. 4,5,4′-Trihydroxy-3,3′-iminodibenzoic acid. 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/4_5_4_-Trihydroxy-3_3_-iminodibenzoic-acid
[73]
National Center for Biotechnology Information. 4,5,4′,5′-Tetrahydroxy-3,3′-iminodibenzoic acid. 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/4,5,4',5'-Tetrahydroxy-3,3'-iminodibenzoicacid
[74]
National Center for Biotechnology Information. Gallic acid. 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Gallic-Acid
[75]
National Center for Biotechnology Information. (+)-Catechin Hydrate. 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Catechin-Hydrate
[76]
National Center for Biotechnology Information. Procyanidin B1. 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Procyanidin-B1
[77]
National Center for Biotechnology Information. oleanolic acid beta-D-glucopyranosyl ester. 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/oleanolic-acid-beta-D-glucopyranosyl-ester
[78]
National Center for Biotechnology Information. Oleanolic acid-3-O-beta-D-glucopyranosyl (1-->2)-alpha-L-arabinopyranoside. 2022. Available from: https://theclinivex.com/rclcfn-oleanolic-acid-3-o-beta-dglucopyranosyl-1-2-alpha-l-arabinopyranoside.html
[79]
Stammer, R.M.; Kleinsimon, S.; Rolff, J.; Jäger, S.; Eggert, A.; Seifert, G.; Delebinski, C.I. Synergistic antitumour properties of viscumTT in alveolar rhabdomyosarcoma. J. Immunol. Res., 2017, 2017, 4874280.
[80]
Estko, M.; Baumgartner, S.; Urech, K.; Kunz, M.; Regueiro, U.; Heusser, P.; Weissenstein, U. Tumour cell derived effects on monocyte/macrophage polarization and function and modulatory potential of Viscum album lipophilic extract in vitro. BMC Complement. Altern. Med., 2015, 15(1), 130.
[http://dx.doi.org/10.1186/s12906-015-0650-3] [PMID: 25902944]
[81]
National Center for Biotechnology Information. Apigenin 6-Cglucoside 8-C-arabinoside. 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Apigenin-6-Cglucoside-8-C-arabinoside
[82]
National Center for Biotechnology Information. Apigenin-7-(2-Oapiosylglucoside. 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/16211399
[83]
National Center for Biotechnology Information. Luteolin7-(2-Oapiosyl-6-O-malonyl)glucoside. 2023. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/102130970
[84]
Malik, E.M.; Müller, C.E. Anthraquinones As Pharmacological Tools and Drugs. Med. Res. Rev., 2016, 36(4), 705-748.
[http://dx.doi.org/10.1002/med.21391] [PMID: 27111664]
[85]
National Center for Biotechnology Information. Beta-Carotene. 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/betacarotene?post=09112020a
[86]
National Center for Biotechnology Information. Lycopene. 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Lycopene
[87]
National Center for Biotechnology Information. Lutein 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Lutein
[88]
Jibril, J.A.; Gazali, Y.M.; Dantani, M.; Alamin, H.; Zannah, B.B. Performance of Balami Rams Fed Graded Levelsof Mistletoe Leaves (Viscum album)and Sorghum Stover in Semi-Arid Zone of Borno State, Nigeria. Niger J. Anim. Sci. Technol., 2020, 3(1)
[89]
Sá, A.G.A.; Moreno, Y.M.F.; Carciofi, B.A.M. Plant proteins as high-quality nutritional source for human diet. Trends Food Sci. Technol., 2020, 97, 170-184.
[http://dx.doi.org/10.1016/j.tifs.2020.01.011]
[90]
Nehete, J.; Narkhede, M.R.; Bhambar, R.S.; Gawali, S. Natural proteins: Sources, isolation, characterization and applications. Pharmacogn. Rev., 2013, 7(14), 107-116.
[http://dx.doi.org/10.4103/0973-7847.120508] [PMID: 24347918]
[91]
Reddy, N.; Yang, Y. Potential of plant proteins for medical applications. Trends Biotechnol., 2011, 29(10), 490-498.
[http://dx.doi.org/10.1016/j.tibtech.2011.05.003] [PMID: 21665302]
[92]
Schaller, G.; Urech, K.; Giannattasio, M. Cytotoxicity of different viscotoxins and extracts from the European subspecies of Viscum album L. Phytother. Res., 1996, 10(6), 473-477.
[http://dx.doi.org/10.1002/(SICI)1099-1573(199609)10:6<473::AID-PTR879>3.0.CO;2-Q]
[93]
National Center for Biotechnology Information. Viscotoxin B. 2022. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Viscotoxin
[94]
Romagnoli, S.; Ugolini, R.; Fogolari, F.; Schaller, G.; Urech, K.; Giannattasio, M.; Ragona, L.; Molinari, H. Viscotoxin A3, 2022.
[95]
Molinari, H.; Romagnoli, S.; Fogolari, F.; Catalano, M.; Urech, K.; Giannattasio, M.; Ragona, L. Viscotoxin C1, 2022.
[96]
Zarkovic, N.; Vukovic, T.; Loncaric, I.; Miletic, M.; Zarkovic, K.; Borovic, S.; Cipak, A.; Sabolovic, S.; Konitzer, M.; Mang, S. An overview on anticancer activities of the Viscum album extract Isorel. Cancer Biother. Radiopharm., 2001, 16(1), 55-62.
[http://dx.doi.org/10.1089/108497801750096041] [PMID: 11279798]
[97]
Kunze, E.; Schulz, H.; Ahrens, H.; Gabius, H.J.; Pathology, T. Lack of an antitumoral effect of immunomodulatory galactoside specific mistletoe lectin on N-methyl-N-nitrosourea-induced urinary bladder carcinogenesis in rats. Exp. Toxicol. Pathol., 1997, 49(3-4), 167-180.
[http://dx.doi.org/10.1016/S0940-2993(97)80004-8] [PMID: 9314050]
[98]
Önay-Uçar, E.; Erol, Ö.; Kandemir, B.; Mertoğlu, E.; Karagöz, A.; Arda, N. Lack of an antitumoral effect of immunomodulatory galactoside-specific mistletoe lectin on N-methyl-N-nitrosoureainduced urinary bladder carcinogenesis in rats. Evid. Based Complement. Alternat. Med., 2012, 2012, 958740.
[99]
Burger, A.M.; Mengs, U.; Schüler, J.B.; Fiebig, H-H. Antiproliferative activity of an aqueous mistletoe extract in human tumor cell lines and xenografts in vitro. Arzneimittelforschung, 2001, 51(9), 748-757.
[PMID: 11642008]
[100]
Vervecken, W.; Kleff, S.; Pfüller, U.; Büssing, A. Induction of apoptosis by mistletoe lectin I and its subunits. No evidence for cytotoxic effects caused by isolated A- and B-chains. Int. J. Biochem. Cell Biol., 2000, 32(3), 317-326.
[http://dx.doi.org/10.1016/S1357-2725(99)00135-1] [PMID: 10716629]
[101]
Rostock, M.; Huber, R.; Greiner, T.; Fritz, P.; Scheer, R.; Schueler, J.; Fiebig, H.H. Anticancer activity of a lectin-rich mistletoe extract injected intratumorally into human pancreatic cancer xenografts. Anticancer Res., 2005, 25(3B), 1969-1975.
[PMID: 16158932]
[102]
Steinborn, C.; Klemd, A.M.; Sanchez-Campillo, A.S.; Rieger, S.; Scheffen, M.; Sauer, B.; Garcia-Käufer, M.; Urech, K.; Follo, M.; Ücker, A.; Kienle, G.S.; Huber, R.; Gründemann, C. Viscum album neutralizes tumor-induced immunosuppression in a human In vitro cell model. PLoS One, 2017, 12(7), e0181553.
[http://dx.doi.org/10.1371/journal.pone.0181553] [PMID: 28719632]
[103]
Thies, A.; Dautel, P.; Meyer, A.; Pfüller, U.; Schumacher, U. Lowdose mistletoe lectin-I reduces melanoma growth and spread in a scid mouse xenograft model. Br. J. Cancer, 2008, 98(1), 106-112.
[http://dx.doi.org/10.1038/sj.bjc.6604106] [PMID: 18026191]
[104]
žarković, N.; Kališnik, T.; Lončarić, I.; Borović, S.; Mang, S.; Kissel, D.; Konitzer, M.; Jurin, M.; Grainza, S. Comparison of the effects of Viscum album lectin ML-1 and fresh plant extract (Isorel) on the cell growth In vitro and tumorigenicity of melanoma B16F10. Cancer Biother. Radiopharm., 1998, 13(2), 121-131.
[http://dx.doi.org/10.1089/cbr.1998.13.121] [PMID: 10850348]
[105]
Antony, S.; Kuttan, R.; Kuttan, G. Effect of viscum album in the inhibition of lung metastasis in mice induced by B16F10 melanoma cells. J. Exp. Clin. Cancer Res., 1997, 16(2), 159-162.
[PMID: 9261741]
[106]
Büssing, A. Induction of apoptosis by the mistletoe lectins: A review on the mechanisms of cytotoxicity mediated by Viscum album L. Apoptosis, 1996, 1(1), 25-32.
[http://dx.doi.org/10.1007/BF00142075]
[107]
Kirsch, A.; Hajto, T. Case reports of sarcoma patients with optimized lectin-oriented mistletoe extract therapy. J. Altern. Complement. Med., 2011, 17(10), 973-979.
[http://dx.doi.org/10.1089/acm.2010.0596] [PMID: 22010781]
[108]
Hajto, T.; Hostanska, K.; Fischer, J.; Saller, R. Immunomodulatory effects of Viscum album agglutinin-l on natural immunity. Anticancer Drugs, 1997, 8(Suppl. 1), S43-S46.
[http://dx.doi.org/10.1097/00001813-199704001-00010] [PMID: 9179367]
[109]
Lavelle, E.C.; Grant, G.; Pusztai, A.; Pfüller, U.; Leavy, O.; McNeela, E.; Mills, K.H.G.; O’Hagan, D.T. Mistletoe lectins enhance immune responses to intranasally co-administered herpes simplex virus glycoprotein D2. Immunology, 2002, 107(2), 268-274.
[http://dx.doi.org/10.1046/j.1365-2567.2002.01492.x] [PMID: 12383207]
[110]
Uniprot. Viscumin 2022.
[111]
Uniprot. Beta galactoside specific lectin II. 2022.
[112]
Uniprot. Beta galactoside specific lectin III. 2022.
[113]
Liu, Z.; Luo, Y.; Zhou, T.T.; Zhang, W.Z. Could plant lectins become promising anti-tumour drugs for causing autophagic cell death? Cell Prolif., 2013, 46(5), 509-515.
[http://dx.doi.org/10.1111/cpr.12054] [PMID: 24033443]
[114]
Pryme, I.F.; Bardocz, S.; Pusztai, A.; Ewen, S.W. Suppression of growth of tumour cell lines In vitro and tumours in vivo by mistletoe lectins. Histol. Histopathol., 2006, 21(3), 285-299.
[PMID: 16372250]
[115]
Jadhav, R.B.; Jadhav, N.; Patil, C.R.; Chaudhari, K.B.; Wagh, J.P.; Surana, S.J. Diuretic and natriuretic activity of two mistletoe species in rats. Pharmacognosy Res., 2010, 2(1), 50-57.
[http://dx.doi.org/10.4103/0974-8490.60576] [PMID: 21808540]
[116]
Tugbobo Oladimeji, S.; Abegunde Segun, M.; Awonegan Paul, A.; Akinyede Kolajo, A.; Oyewusi Habeebat, A. Dietary protection by Tapinanthus globiferus (Mistletoe) leaf extract against prontosilinduced clastogenicity in mice in vivo. GSC Biol. Pharmaceut. Sci., 2020, 10(3), 160-163.
[http://dx.doi.org/10.30574/gscbps.2020.10.3.0067]
[117]
Oche, J-R.I.; Johnson, T.O.; Akinsanmi, A.O.; Jaryum, K.H.; Francis, T. In vitro Antioxidant Activity and Inhibition of Fe2+ and SNP Lipid Peroxidation of African Mistletoes (Tapinanthus globiferus) from Three Selected Host Plants in Jos Plateau State Nigeria. J Appl Life Sci Int, 2019, 20(4), 1-10.
[118]
Shalini, K.S.; Yengkhom, O.; Subramani, P.A. Polysaccharide fraction of the hemi-parasitic mistletoe, Dendrophthoe falcata (L) Ettingsh leaves enhances innate immune responses and disease resistance in Oreochromis niloticus (Linnaeus). Int. J. Res. Pharm. Sci., 2019, 10(1), 56-64.
[119]
Hardiyanti, R.; Marpaung, L. Phytochemical and toxicity test of nhexan extracts of duku’s mistletoe leaf (Dendrophtoe pentandra) and (Scurrula ferruginea) collected from Medan, Indonesia. AIP Conf. Proc., 2018, 2049(1), 030015.
[http://dx.doi.org/10.1063/1.5082516]
[120]
Lorenzana-Jiménez, M.; Ávila, M.E.; Figueroa, A.; Mendiola-Almaraz, L.; Guerrero, G.A.M.; Lemini, C. The Mexican mistletoe Struthanthus venetus (HBK Blume) inhibits proliferation and synergizes antagonistic actions of Tamoxifen and Fulvestrant in breast cancer MCF-7 cells. J. Pharmacogn. Phytother., 2018, 10(8), 133-141.
[121]
Ohikhena, F.U.; Wintola, O.A.; Afolayan, A.J. Quantitative phytochemical constituents and antioxidant activities of the mistletoe, phragmanthera capitata (sprengel) balle extracted with different solvents. Pharmacognosy Res., 2018, 10(1), 16-23.
[PMID: 29568182]
[122]
Thoa, N.T.; Van Cuong, T. Phytochemical components, antioxidant and cytotoxic activities of Mulberry mistletoe (Loranthus parasiticus Merr) leaves extracts. Asian J. Biotechnol. Bioresour. Technol., 2018, 2(4), 1-11.
[123]
Agbo, M.O.; Lai, D.; Okoye, F.B.C.; Osadebe, P.O.; Proksch, P. Antioxidative polyphenols from Nigerian mistletoe Loranthus micranthus (Linn.) parasitizing on Hevea brasiliensis. Fitoterapia, 2013, 86, 78-83.
[http://dx.doi.org/10.1016/j.fitote.2013.02.006] [PMID: 23422225]
[124]
Choudhary, M.I.; Maher, S.; Begum, A.; Abbaskhan, A.; Ali, S.; Khan, A. Shafique-ur-Rehman; Atta-ur-Rahman. Characterization and antiglycation activity of phenolic constituents from Viscum album (European Mistletoe). Chem. Pharm. Bull. (Tokyo), 2010, 58(7), 980-982.
[http://dx.doi.org/10.1248/cpb.58.980] [PMID: 20606351]
[125]
Kim, B.K.; Choi, M.J.; Park, K.Y.; Cho, E.J. Protective effects of Korean mistletoe lectin on radical-induced oxidative stress. Biol. Pharm. Bull., 2010, 33(7), 1152-1158.
[http://dx.doi.org/10.1248/bpb.33.1152] [PMID: 20606306]
[126]
Singh, B.N.; Saha, C.; Galun, D.; Upreti, D.K.; Bayry, J.; Kaveri, S.V. European Viscum album: A potent phytotherapeutic agent with multifarious phytochemicals, pharmacological properties and clinical evidence. RSC Advances, 2016, 6(28), 23837-23857.
[http://dx.doi.org/10.1039/C5RA27381A] [PMID: 26998255]
[127]
Majeed, M.; Pirzadah, T.B.; Mir, M.A.; Hakeem, K.R.; Alharby, H.F.; Alsamadany, H.; Bamagoos, A.A.; Rehman, R.U. Comparative Study on Phytochemical Profile and Antioxidant Activity of an Epiphyte, Viscum album L. (White Berry Mistletoe), Derived from Different Host Trees. Plants, 2021, 10(6), 1191.
[http://dx.doi.org/10.3390/plants10061191] [PMID: 34208051]
[128]
Pietrzak, W.; Nowak, R. Impact of Harvest Conditions and Host Tree Species on Chemical Composition and Antioxidant Activity of Extracts from Viscum album L. Molecules, 2021, 26(12), 3741.
[http://dx.doi.org/10.3390/molecules26123741] [PMID: 34205329]
[129]
Hegde, P.; Maddur, M.S.; Friboulet, A.; Bayry, J.; Kaveri, S.V. Viscum album exerts anti-inflammatory effect by selectively inhibiting cytokine-induced expression of cyclooxygenase-2. PLoS One, 2011, 6(10), e26312.
[http://dx.doi.org/10.1371/journal.pone.0026312] [PMID: 22028854]
[130]
Saha, C.; Hegde, P.; Friboulet, A.; Bayry, J.; Kaveri, S.V. Viscum album-mediated COX-2 inhibition implicates destabilization of COX-2 mRNA. PLoS One, 2015, 10(2), e0114965.
[http://dx.doi.org/10.1371/journal.pone.0114965] [PMID: 25664986]
[131]
Maddur, M.S.; Trinath, J.; Rabin, M.; Bolgert, F.; Guy, M.; Vallat, J.M.; Magy, L.; Balaji, K.N.; Kaveri, S.V.; Bayry, J. Intravenous immunoglobulin-mediated expansion of regulatory T cells in autoimmune patients is associated with increased prostaglandin E2 levels in the circulation. Cell. Mol. Immunol., 2015, 12(5), 650-652.
[http://dx.doi.org/10.1038/cmi.2014.117] [PMID: 25482074]
[132]
Nakanishi, M. Multifaceted roles of PGE 2 in inflammation and cancer, Seminars in immunopathology; Springer: Heidelberg, 2013, pp. 123-137.
[133]
Lyu, S.Y.; Park, W.B. Effects of Korean mistletoe lectin (Viscum album coloratum) on proliferation and cytokine expression in human peripheral blood mononuclear cells and T-lymphocytes. Arch. Pharm. Res., 2007, 30(10), 1252-1264.
[http://dx.doi.org/10.1007/BF02980266] [PMID: 18038904]
[134]
Podlech, O.; Harter, P.N.; Mittelbronn, M.; Pöschel, S.; Naumann, U. Fermented mistletoe extract as a multimodal antitumoral agent in gliomas. Evid. Based Complement. Alternat. Med., 2012, 2012(10), 501796.
[135]
Hong, C.E.; Lyu, S.Y. The antimutagenic effect of mistletoe lectin (Viscum album L. var. coloratum agglutinin). Phytother. Res., 2012, 26(5), 787-790.
[http://dx.doi.org/10.1002/ptr.3639] [PMID: 22084060]
[136]
Patel, S.; Panda, S. Emerging roles of mistletoes in malignancy management. 3 Biotech., 2014, 4(1), 13-20.
[137]
Baek, J.H.; Jeon, Y.; Han, K.W.; Jung, D.H.; Kim, K.O. Effect of mistletoe extract on tumor response in neoadjuvant chemoradiotherapy for rectal cancer: A cohort study. World J. Surg. Oncol., 2021, 19(1), 178.
[http://dx.doi.org/10.1186/s12957-021-02293-4] [PMID: 34130688]
[138]
Lee, R.T.; Yang, P.; Alahmadi, A.; McQuade, J.; Yuan, E.; Difeo, A.; Narla, G.; Kaseb, A. Mistletoe Extract Viscum Fraxini-2 for Treatment of Advanced Hepatocellular Carcinoma: A Case Series. Case Rep. Oncol., 2021, 14(1), 224-231.
[http://dx.doi.org/10.1159/000511566] [PMID: 33776708]
[139]
Kim, K.-W.; Yang, S.-H.; Kim, J.-B. Protein Fractions from Korean Mistletoe (Viscum Album coloratum) Extract Induce Insulin Secretion from Pancreatic Beta Cells. Evid. Based Complement. Alternat. Med., 2014, 2014, 703624.
[140]
Cho, H. Protein tyrosine phosphatase 1B (PTP1B) and obesity.Vitamins & Hormones; Litwack, G., Ed.; Elsevier: Department of Chemistry, Inha University: Incheon, Korea , 2013; 91, pp. 405-424.
[141]
Shahaboddin, M.E.; Pouramir, M.; Moghadamnia, A-A.; Lakzaei, M.; Mirhashemi, S.M.; Motallebi, M. Pharmacology, Antihyperglycemic and antioxidant activity of Viscum album extract. AJPP, 2011, 5(3), 433-436.
[142]
Adaramoye, O.; Amanlou, M.; Habibi-Rezaei, M.; Pasalar, P.; Ali, M.M. Methanolic extract of African mistletoe (Viscum album) improves carbohydrate metabolism and hyperlipidemia in streptozotocin-induced diabetic rats. Asian Pac. J. Trop. Med., 2012, 5(6), 427-433.
[http://dx.doi.org/10.1016/S1995-7645(12)60073-X] [PMID: 22575973]
[143]
Nazaruk, J.; Orlikowski, P. Phytochemical profile and therapeutic potential of Viscum album L. Nat. Prod. Res., 2016, 30(4), 373-385.
[http://dx.doi.org/10.1080/14786419.2015.1022776] [PMID: 25813519]
[144]
Bachhav, S.S.; Patil, S.D.; Bhutada, M.S.; Surana, S.J. Oleanolic acid prevents glucocorticoid-induced hypertension in rats. Phytother. Res., 2011, 25(10), 1435-1439.
[http://dx.doi.org/10.1002/ptr.3431] [PMID: 21953707]
[145]
Poruthukaren, K.J.; Palatty, P.L.; Baliga, M.S.; Suresh, S. Clinical evaluation of Viscum album mother tincture as an antihypertensive: A pilot study. J. Evid. Based Complementary Altern. Med., 2014, 19(1), 31-35.
[http://dx.doi.org/10.1177/2156587213507726] [PMID: 24647376]
[146]
Karagöz, A.; Kesici, S.; Vural, A.; Usta, M.; Tezcan, B.; Semerci, T.; Teker, E. Cardioprotective effects of Viscum album L. ssp. album (Loranthaceae) on isoproterenol-induced heart failure via regulation of the nitric oxide pathway in rats. Anatol. J. Cardiol., 2016, 16(12), 923-930.
[http://dx.doi.org/10.14744/AnatolJCardiol.2016.6780] [PMID: 27443473]
[147]
Sengul, M.; Yildiz, H.; Gungor, N.; Cetin, B.; Eser, Z.; Ercisli, S. Total phenolic content, antioxidant and antimicrobial activities of some medicinal plants. Pak. J. Pharm. Sci., 2009, 22(1), 102-106.
[PMID: 19168430]
[148]
Shah, S.; Rehman, Y.; Iqbal, A.; Rahman, Z.; Zhou, B.; Peng, M.; Li, Z. Phytochemical Screening and Antimicrobial Activities of Stem, Leaves and Fruit Extracts of Viscum album L. J. Pure Appl. Microbiol., 2017, 11(3), 1337-1349.
[http://dx.doi.org/10.22207/JPAM.11.3.14]
[149]
Assaf, A.M.; Haddadin, R.N.; Aldouri, N.A.; Alabbassi, R.; Mashallah, S.; Mohammad, M.; Bustanji, Y. Anti-cancer, antiinflammatory and anti-microbial activities of plant extracts used against hematological tumors in traditional medicine of Jordan. J. Ethnopharmacol., 2013, 145(3), 728-736.
[http://dx.doi.org/10.1016/j.jep.2012.11.039] [PMID: 23246454]
[150]
Keskin, D.; Ceyhan-Guvensen, N. Determination of bioactive components and antimicrobial activity of methanolic extracts of mistletoe leaves (Viscum Album L. subsp. Album L.). Fresenius Environ. Bull., 2018, 27(12), 7991-7996.
[151]
Butu, A.; Rodino, S.; Ferdes, M.; Butu, M. Molecular dynamics simulation for seven structures of viscotoxin. Dig. J. Nanomater., 2013, 8(1), 1-10.
[152]
Iloki-Assanga, S.B.; Lewis-Luján, L.M.; Lara-Espinoza, C.L.; Gil-Salido, A.A.; Fernandez-Angulo, D.; Rubio-Pino, J.L.; Haines, D.D. Solvent effects on phytochemical constituent profiles and antioxidant activities, using four different extraction formulations for analysis of Bucida buceras L. and Phoradendron californicum. BMC Res. Notes, 2015, 8(1), 396.
[http://dx.doi.org/10.1186/s13104-015-1388-1] [PMID: 26323940]
[153]
Wang, Z.; Hwang, S.H.; Guillen Quispe, Y.N.; Gonzales Arce, P.H.; Lim, S.S. Investigation of the antioxidant and aldose reductase inhibitory activities of extracts from Peruvian tea plant infusions. Food Chem., 2017, 231, 222-230.
[http://dx.doi.org/10.1016/j.foodchem.2017.03.107] [PMID: 28450000]
[154]
López-Martínez, S.; Navarrete-Vázquez, G.; Estrada-Soto, S.; León-Rivera, I.; Rios, M.Y. Chemical constituents of the hemiparasitic plant Phoradendron brachystachyum DC Nutt (Viscaceae). Nat. Prod. Res., 2013, 27(2), 130-136.
[http://dx.doi.org/10.1080/14786419.2012.662646] [PMID: 22360797]
[155]
Ramírez-Espinosa, J.J.; García-Jiménez, S.; Rios, M.Y.; Medina-Franco, J.L.; López-Vallejo, F.; Webster, S.P.; Binnie, M.; Ibarra-Barajas, M.; Ortiz-Andrade, R.; Estrada-Soto, S. Antihyperglycemic and sub-chronic antidiabetic actions of morolic and moronic acids, In vitro and in silico inhibition of 11β-HSD 1. Phytomedicine, 2013, 20(7), 571-576.
[http://dx.doi.org/10.1016/j.phymed.2013.01.013] [PMID: 23453304]
[156]
Bastos, I.; Oliveira, T.; Barbosa, J.; Neto-Jr, J.; Neves, W.; Silva, T. Avaliação da toxicidade aguda, anti-inflamatória e cicatrizante do extrato das folhas de duas especies do gênero Phoradendron. Rev. Bras. Farmacogn., 2015, 94.
[157]
Rios, M.Y.; López-Martínez, S.; López-Vallejo, F.; Medina-Franco, J.L.; Villalobos-Molina, R.; Ibarra-Barajas, M.; Navarrete-Vazquez, G.; Hidalgo-Figueroa, S.; Hernández-Abreu, O.; Estrada-Soto, S. Vasorelaxant activity of some structurally related triterpenic acids from Phoradendron reichenbachianum (Viscaceae) mainly by NO production: Ex vivo and in silico studies. Fitoterapia, 2012, 83(6), 1023-1029.
[http://dx.doi.org/10.1016/j.fitote.2012.05.014] [PMID: 22659049]
[158]
Woźniak, Ł.; Skąpska, S.; Marszałek, K. Ursolic acid—a pentacyclic triterpenoid with a wide spectrum of pharmacological activities. Molecules, 2015, 20(11), 20614-20641.
[http://dx.doi.org/10.3390/molecules201119721] [PMID: 26610440]
[159]
Jacobo-Salcedo, M. d. R.; Alonso-Castro, A.J.; Salazar-Olivo, L.A.; Carranza-Alvarez, C.; González-Espíndola, L.Á.; Domínguez, F.; Maciel-Torres, S.P.; García-Lujan, C.; González-Martínez, M. d. R.; Gómez-Sánchez, M.J.N. p. c. Antimicrobial and cytotoxic effects of Mexican medicinal plants. Sage J, 2011, 26(12), 1925-1928.
[http://dx.doi.org/10.1177/1934578X1100601234]

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