Generic placeholder image

Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Case Report

Multiple Parotid Sebaceous Lymphadenoma: A Case Report and Review of the Literature

Author(s): Yanhui Yang, Mengjie Tang, Zhiyuan Wang, Yi Fu and Xiaoping Yu*

Volume 20, 2024

Published on: 02 October, 2023

Article ID: e250823220364 Pages: 5

DOI: 10.2174/1573405620666230825113417

open_access

Open Access Journals Promotions 2
Abstract

Introduction/Background: Sebaceous lymphadenoma is a rare parotid gland neoplasm. Up to now, there have been several studies that have discussed the imaging manifestations of salivary sebaceous lymphadenoma. In this paper, we have reported a case of multiple parotid sebaceous lymphadenoma demonstrated by ultrasound, CT scan, and MRI examinations, including diffusion-weighted imaging. To the best of our knowledge, this report is the first one on DWI findings of sebaceous lymphadenomas, and also the first report on multiple lesions in unilateral parotid gland.

Case Presentation: A 41-year-old woman presented with a nodule in the left parotid region. The lesion has grown slowly for 2 months and was not associated with any discomfort. Ultrasound, CT scan, and MRI examinations, including diffusion-weighted imaging, showed multiple nodules in the left parotid gland of a 41-year-old woman. These nodules were heterogeneous on CT scan and MRI examinations, and intratumorally multifocal fat and cystic areas were detected. On ultrasound examination images, these lesions were heterogeneous hypoechoic echotexture with multifocal irregular hyperechogenic areas, without significant blood flow. The patient underwent a left parotidectomy. Histopathologic sections showed nests of sebocytes distributed in lymphoid follicles and lymphocyte background, with obvious cystic changes. The patient recovered after receiving left parotidectomy. The microscopy diagnosis was parotid sebaceous lymphadenoma.

Conclusion: This case highlights the main imaging feature of parotid sebaceous lymphadenomas, namely an intraparotid heterogeneous nodule containing multifocal fat and cystic areas, and its possible origination from an intraparotid lymph node. This case also indicates that this rare lesion may involve multiple occurrences.

Keywords: Major salivary gland, Neoplasm, Sebaceous, Ultrasound, X-ray computed tomography, MRI.

[1]
Kurokawa H, Murata T, Fukuyama H, Kajiyama M. Sebaceous lymphadenoma in the midline of the maxilla: Report of case. J Oral Maxillofac Surg 1999; 57(12): 1461-3.
[http://dx.doi.org/10.1016/S0278-2391(99)90734-6] [PMID: 10596670]
[2]
Janus JR, Mzaik O, Bhatt AA. Parotid sebaceous lymphadenoma associated with Sjogren’s syndrome: Review of pathologic and radiologic characteristics and clinical presentation. J Clin Imaging Sci 2022; 12: 14.
[http://dx.doi.org/10.25259/JCIS_14_2022] [PMID: 35510245]
[3]
While B, Whiteside OJH, Desai V, Gurr P. Sebaceous lymphadenoma: A case report and review of the literature. Ear Nose Throat J 2010; 89(8): E22-3.
[http://dx.doi.org/10.1177/014556131008900806] [PMID: 20737364]
[4]
Honda K, Okada F, Ando Y, Matsumoto S, Mori H. Sebaceous lymphadenoma demonstrated by CT and MRI. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109(5): e59-62.
[http://dx.doi.org/10.1016/j.tripleo.2009.12.052] [PMID: 20416520]
[5]
Shekarkhar G, Soleimanpour H, Jafari SH, Zamani F. Sebaceous lymphadenoma of parotid: Imaging, cytological, and histological findings in detail. Case Rep Pathol 2018; 2018: 1-4.
[http://dx.doi.org/10.1155/2018/2915907] [PMID: 29850339]
[6]
Majeed M, Murray B, Hume W, Makura Z. Sebaceous lymphadenoma of the parotid gland. Dentomaxillofac Radiol 2008; 37(5): 300-4.
[http://dx.doi.org/10.1259/dmfr/72624194] [PMID: 18606753]
[7]
Dababneh MN, Griffith CC, Patel MR, Magliocca KR. Sebaceous lymphadenoma: Radiology–pathology correlation. Head Neck Pathol 2021; 15(2): 593-8.
[http://dx.doi.org/10.1007/s12105-020-01266-5] [PMID: 33398686]
[8]
Seethala RR, Thompson LDR, Gnepp DR, et al. Lymphadenoma of the salivary gland: Clinicopathological and immunohistochemical analysis of 33 tumors. Mod Pathol 2012; 25(1): 26-35.
[http://dx.doi.org/10.1038/modpathol.2011.135] [PMID: 21892186]
[9]
Gnepp DR, Brannon R. Sebaceous neoplasms of salivary gland origin. Report of 21 cases. Cancer 1984; 53(10): 2155-70.
[http://dx.doi.org/10.1002/1097-0142(19840515)53:10<2155::AID-CNCR2820531026>3.0.CO;2-F] [PMID: 6704903]
[10]
Viswanathan K, Maleki Z, Pantanowitz L, Cantley R, Faquin WC. Cytomorphology and diagnostic pitfalls of sebaceous and nonsebaceous salivary gland lymphadenoma: A multi‐institutional study. Diagn Cytopathol 2021; 49(1): 83-95.
[http://dx.doi.org/10.1002/dc.24602] [PMID: 32926569]
[11]
McGavran MH, Bauer WC, Ackerman LV. Sebaceous lymphadenoma of the parotid salivary gland. Cancer 1960; 13(6): 1185-7.
[http://dx.doi.org/10.1002/1097-0142(196011/12)13:6<1185::AID-CNCR2820130605>3.0.CO;2-P] [PMID: 13773927]
[12]
Rawson AJ, Horn RC Jr. Sebaceous glands and sebaceous gland-containing tumors of the parotid salivary gland; with a consideration of the histogenesis of papillary cystadenoma lymphomatosum. Surgery 1950; 27(1): 93-101, illust.
[PMID: 15402893]
[13]
Chandrasekar T, Ramani P, Anuja N, et al. Unilocular cystic sebaceous lymphadenoma: A rare tumour. Ann R Coll Surg Engl 2007; 89(4): 1-3.
[http://dx.doi.org/10.1308/147870807X160489] [PMID: 17535604]
[14]
Squillaci S, Marchione R, Piccolomini M. Cystic sebaceous lymphadenoma of the parotid gland: Case report and review of the literature. Pathologica 2011; 103(2): 32-9.
[PMID: 21797140]
[15]
Gnepp DR, Sporck FT. Benign lymphoepithelial parotid cyst with sebaceous differentiation--cystic sebaceous lymphadenoma. Am J Clin Pathol 1980; 74(5): 683-7.
[http://dx.doi.org/10.1093/ajcp/74.5.683] [PMID: 7446474]

© 2024 Bentham Science Publishers | Privacy Policy