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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Review Article

miRNAs Delivery for Cancer-associated Fibroblasts’ Activation and Drug Resistance in Cancer Microenvironment

Author(s): Sara Anajafi, Mahdi Paryan, Amineh Khoshnazar, Masoud Soleimani and Samira Mohammadi-Yeganeh*

Volume 24, Issue 3, 2024

Published on: 06 October, 2023

Page: [333 - 347] Pages: 15

DOI: 10.2174/1871530323666230823094556

Price: $65

Abstract

Cancer-associated fibroblasts (CAFs) as a major component of cancer stroma contribute to diverse procedures of most solid tumors and might be a targeted cancer therapy approach. Their specified features, related signaling pathways, distinct biomarkers, and sub-populations need to be deciphered. There is a need for CAF extraction or induction for in vitro investigations. Some miRNAs could activate CAF-like phenotype and they also interfere in CAF-mediated drug resistance, aggressiveness, and metastatic behaviors of several cancer cell types. Due to the complex relevance of miRNA and CAFs, these non-coding oligonucleotides may serve as attractive scope for anti-cancer targeted therapies, but the lack of an efficient delivery system is still a major hurdle. Here, we have summarized the investigated information on CAF features, isolation, and induction procedures, and highlighted the miRNA-CAF communications, providing special insight into nano-delivery systems.

Keywords: miRNA, cancer-associated fibroblasts (CAF), tumor microenvironment, signaling pathways, drug delivery, drug resistance.

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