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Current Organic Synthesis

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Mini-Review Article

Pyrazoline and Analogs: Substrate-based Synthetic Strategies

Author(s): Himanshu Singh*, Rajnish Kumar and Avijit Mazumder

Volume 21, Issue 7, 2024

Published on: 07 September, 2023

Page: [823 - 836] Pages: 14

DOI: 10.2174/1570179421666230822100043

Price: $65

Open Access Journals Promotions 2
Abstract

Among the many reports published on strategies applicable to synthesizing pyrazolines and its analogs, The 1,3-dipolar cycloaddition offers a remarkably wide range of utility. Many 1,3-dipolar cycloaddition reactions used for the synthesis of pyrazolines provide better selectivity, eco-friendly, and less expensive chemical processes. In the presented study, we have reviewed various recently adopted strategies for the synthesis of pyrazoline, which followed the 1,3-dipolar cycloaddition reactions mechanism and classified them based on starting materials such as nitrile imines, diazo compounds, different zwitter ions, chalcones, and isoprene units. The manuscript also focused on the synthesis of pyrazolines starting from Seyferth−Gilbert reagents (SGR) and Psilostachyin (PSH) reagents. We hope this work will help those engaged or have plans to research pyrazoline or its analogs, as synthetic protocols based on starting material are rarely available for pyrazolines. Thus, this article holds a valuable complement to the development of newer pyrazoline and its derivatives.

Keywords: Pyrazoline, synthesis, 1, 3-dipolar cycloaddition, huisgen zwitter ion, nitrile imines, diazo compounds, chalcones.

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