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Current Chinese Science


ISSN (Print): 2210-2981
ISSN (Online): 2210-2914

Letter to the Editor Section: Pharmacology

Medicinal Importance and Pharmacological Activity of Daturaolone: An Active Phytochemical of Pentacyclic Triterpenoid Class

Author(s): Dinesh Kumar Patel*

Volume 3, Issue 5, 2023

Published on: 08 September, 2023

Page: [396 - 397] Pages: 2

DOI: 10.2174/2210298103666230821144335

Ha, J.S.; Kang, J.Y.; Kang, J.E.; Park, S.K.; Kim, J.M.; Kim, C.W.; Oh, S.I.; Lee, U.; Kim, D.O.; Heo, H.J. Pentacyclic triterpenoid-rich fraction of the Hardy kiwi (Actinidia arguta) improves brain dysfunction in high fat diet-induced obese mice. Sci. Rep., 2020, 10(1), 5788.
[] [PMID: 32238886]
Żwawiak, J.; Pawełczyk, A.; Olender, D.; Zaprutko, L. Structure and activity of pentacyclic triterpenes codrugs. A Review. Mini Rev. Med. Chem., 2021, 21(12), 1509-1526.
[] [PMID: 33402080]
Xu, C.; Wang, B.; Pu, Y.; Tao, J.; Zhang, T. Techniques for the analysis of pentacyclic triterpenoids in medicinal plants. J. Sep. Sci., 2018, 41(1), 6-19.
[] [PMID: 28862795]
Ghosh, A.; Panda, C.K. Role of pentacyclic triterpenoid acids in the treatment of bladder cancer. Mini Rev. Med. Chem., 2022, 22(9), 1331-1340.
[] [PMID: 34719363]
Khwaza, V.; Mlala, S.; Oyedeji, O.O.; Aderibigbe, B.A. Pentacyclic triterpenoids with nitrogen-containing heterocyclic moiety, Privileged hybrids in anticancer drug discovery. Molecules, 2021, 26(9), 2401.
[] [PMID: 33918996]
Rauf, A.; Maione, F.; Uddin, G.; Raza, M.; Siddiqui, B.S.; Muhammad, N.; Shah, S.U.A.; Khan, H.; De Feo, V.; Mascolo, N. Biological evaluation and docking analysis of daturaolone as potential cyclooxygenase inhibitor. Evid. Based Complement. Alternat. Med., 2016, 2016, 1-7.
[] [PMID: 27042189]
Hafez, G.S.; Firuzi, O.; Asadollahi, M.; Stuppner, H.; Alilou, M.; Jassbi, A.R. Dammarane-type triterpenoid saponins from Salvia russellii Benth. Phytochemistry, 2021, 184, 112653.
[] [PMID: 33524860]
Li, J.; Lin, B.; Wang, G.; Gao, H.; Qin, M. Chemical constituents of Datura stramonium seeds. Zhongguo Zhongyao Zazhi, 2012, 37(3), 319-322.
[PMID: 22568232]
Chávez, H.; Estévez-Braun, A.; Ravelo, Á.G.; González, A.G. First examples of dammarane triterpenes isolated from Celastraceae. Tetrahedron, 1997, 53(18), 6465-6472.
Ayeni, E.A.; Gong, Y.; Yuan, H.; Hu, Y.; Bai, X.; Liao, X. Medicinal plants for anti-neurodegenerative diseases in West Africa. J. Ethnopharmacol., 2022, 285, 114468.
[] [PMID: 34390796]
Lian, W.; Wang, Y.; Zhang, J.; Yan, Y.; Xia, C.; Gan, H.; Wang, X.; Yang, T.; Xu, J.; He, J.; Zhang, W. The genus Datura L. (Solanaceae): A systematic review of botany, traditional use, phytochemistry, pharmacology, and toxicology. Phytochemistry, 2022, 204, 113446.
[] [PMID: 36152725]
Xu, G.B.; Xiao, Y.H.; Zhang, Q.Y.; Zhou, M.; Liao, S.G. Hepatoprotective natural triterpenoids. Eur. J. Med. Chem., 2018, 145, 691-716.
[] [PMID: 29353722]
Ma, L.; Liu, H.; Liu, X.; Yuan, X.; Xu, C.; Wang, F.; Lin, J.; Xu, R.; Zhang, D. Screening S protein – ACE2 blockers from natural prod-ucts: Strategies and advances in the discovery of potential inhibitors of COVID-19. Eur. J. Med. Chem., 2021, 226, 113857.
[] [PMID: 34628234]
Uma Reddy, B.; Routhu, N.K.; Kumar, A. Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2. Microb. Pathog., 2022, 168, 105512.
[] [PMID: 35381324]
Baig, M.W.; Haq, I.; Kazmi, S.T.B.; Zafar, A. Chromatographic method development and metabolite profiling for biomass and extraction optimization of withametelin and daturaolone from D. Innoxia Mill. Arab. J. Chem., 2022, 15(9), 104052.
Bawazeer, S.; Rauf, A. In Vitro Antibacterial and antifungal potential of amyrin-type triterpenoid isolated from Datura metel linnaeus. BioMed Res. Int., 2021, 2021, 1-5.
[] [PMID: 34589544]
Bawazeer, S.; Rauf, A.; Bawazeer, S. Gastrointestinal Motility, muscle relaxation, antipyretic and acute toxicity screening of amyrin type triterpenoid (Daturaolone) Isolated From Datura metel Linnaeus (Angel’s Trumpet). Fruits. Front. Pharmacol., 2020, 11, 544794.
[] [PMID: 33101017]
Baig, M.W.; Fatima, H.; Akhtar, N.; Hussain, H.; Okla, M.K.; Al-Hashimi, A.; Al-Qahtani, W.H. AbdElgawad, H.; Haq, I. Anti-inflammatory potential of daturaolone from Datura innoxia mill.: In Silico, In vitro and In vivo studies. Pharmaceuticals, 2021, 14(12), 1248.
[] [PMID: 34959649]
Baig, M.W.; Majid, M.; Nasir, B.; Bungau, S.; Haq, I.U. Toxicity evaluation induced by single and 28-days repeated exposure of withametelin and daturaolone in Sprague Dawley rats. Front. Pharmacol., 2022, 2022, 13.
Bawazeer, S.; Rauf, A.; Bawazeer, S. Potent In vitro α-Glucosidase and β -Secretase inhibition of amyrin-type triterpenoid Isolated from Datura metel linnaeus (Angel’s Trumpet) fruits. BioMed Res. Int., 2020, 2020, 1-5.
[] [PMID: 32908922]
Grace, M.H.; Saleh, M.M. Hepato-protective effect of daturaolone isolated from Solanum arundo. Pharmazie, 1996, 51(8), 593-595.
[PMID: 8794471]

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