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Current Molecular Pharmacology

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ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

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Review Article

The Targeted Therapies for Osteosarcoma via Six Major Pathways

Author(s): Shuxing Wang, Quanlei Ren, Guoqing Li, Xiaoxuan Zhao, Xing Zhao and Zhen Zhang*

Volume 17, 2024

Published on: 11 October, 2023

Article ID: e210823220109 Pages: 17

DOI: 10.2174/1874467217666230821142839

open_access

Abstract

Osteosarcoma is the most common primary bone malignancy and has a high tendency of local invasion. Although a lot of studies have focused on chemotherapy and combination chemotherapy regimens in recent years, still, there is no particularly perfect regimen for the treatment of relapsed or metastatic OS, and the prognosis is still relatively poor. As a new therapeutic method, targeted therapy provides a new scheme for patients with osteosarcoma and has a wide application prospect. This article reviews the latest progress of targeted therapy for osteosarcoma, and summarizes the research on the corresponding targets of osteosarcoma through six major pathways. These studies can pave the way for new treatments for osteosarcoma patients who need them.

Keywords: Osteosarcoma, Targeted therapy, Pathway, CCNE1/CDK2, MYC/CDK9, CDK4/CDK6/FOXM1, PTEN/PI3K/AKT1/mTOR, AURKB, VEGFA/vascular endothelial cell growth factor receptor.

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