Title:Potential Therapeutic Applications for Isolinderalactone in Medicine for
the Treatment of Cancers and other Human Complications: An Overview
of Medicinal Importance
Volume: 3
Author(s): Dinesh Kumar Patel*Kanika Patel
Affiliation:
- Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences,
Prayagraj, Uttar Pradesh, India
Keywords:
Lindera aggregate, lindera species, isolinderalactone, ovarian cancer, human glioblastoma, breast cancer, nonsmall cell lung cancer, inflammation, prolyl endopeptidase.
Abstract:
Background: Herbal medicines have been used in both traditional and modern medicine
for the treatment of numerous kinds of human disorders and associated secondary complications.
Lindera species has an important place in traditional medicine and provides a great source of
structurally diverse molecules with important pharmacological potential. Lindera strychnifolia is
used as remedies for the treatment of menstruation complications, frequent urination, and
vomiting. Isolinderalactone is a sesquiterpene class phytochemical isolated from the root extracts
of Lindera aggregate.
Methods: Biological importance and pharmacological activities of isolinderalactone have been
investigated in the present work through scientific data analysis of different scientific research
work. Scientific data on isolinderalactone have been collected from Google, Google Scholar,
ScienceDirect, PubMed and Scopus using the terms isolinderalactone, Lindera species, and
terpenes and analyzed in the present work in order to know its therapeutic potential in medicine.
Results: Present work signified the biological importance of isolinderalactone in medicine, which
can modulate several physiological functions in the human body. Isolinderalactone exhibits distinct
anticancer profiles both in vitro and in vivo. Present review data signified the biological importance
of isolinderalactone in medicine, as it exhibits significant potential on human ovarian cancer cells,
glioblastoma, breast cancer, and non-small cell lung cancer. Furthermore, its biological
effectiveness is mainly because of its anti-inflammatory activity, prolyl endopeptidase inhibitory
potential, angiogenic activity, and anti-metastatic effect in medicine. The present study also
summarized the biological significance of Lindera species and sesquiterpenoids in medicine
reported for different pharmacological activities.
Conclusion: The present work highlighted the biological importance and therapeutic potential of
isolinderalactone in medicine.
