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Review Article

Expanded Therapeutic Applications of Holarrhena Antidysenterica: A Review

Author(s): Ruchi Tiwari, Charul Khatri, Lalit Kumar Tyagi and Gaurav Tiwari*

Volume 27, Issue 9, 2024

Published on: 21 September, 2023

Page: [1257 - 1275] Pages: 19

DOI: 10.2174/1386207326666230821102502

Price: $65

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Abstract

Background: The use of medicinal plants as a rich resource of therapeutic agents in the treatment and prevention of diseases & ailments has been recognized for millennia and is highly regarded worldwide. Holarrhena antidysenterica (H. antidysenterica), also called kurchi, or kutaj, has been utilized since the dawn of time, Apocynaceae member, also known as H. pubescens, is praised for the medicinal uses of its stem bark, leaves, and seeds in Ayurveda.

Objective: The study concentrated on aggregate information regarding H. antidysenterica's therapeutic effects. The purpose of the study was to compile pharmacological activities of H. antidysentrica seeds.

Methods: Regardless of its broad variety of biological and possible therapeutic uses, there has been increasing concern regarding the use of H. antidysenterica.

Result: Various phytochemicals have been extracted from H. antidysenterica in recent years and have demonstrated typical pharmacological properties, including antibacterial, anti-diarrhoeal, anti-diabetic, anti-oxidant, anti-urolithic, and anti-inflammatory activity.

Conclusion: This review paper investigated the in-depth description and pharmacological properties of the plant, which produced significant findings on the chemical components present and also verified the traditionally claimed properties associated with the plant.

Keywords: H. antidysenterica, therapeutic applications, antidiabetic activity, anti-diarrheal activity, antioxidant activity, antibacterial activity.

« Previous Next »
[1]
Dey, A.; De, J.N. Ethnobotanical survey of Purulia district, West Bengal, India for medicinal plants used against gastrointestinal disorders. J. Ethnopharmacol., 2012, 143(1), 68-80.
[http://dx.doi.org/10.1016/j.jep.2012.05.064] [PMID: 22721882]
[2]
Chakraborty, A.; Brantner, A.H. Antibacterial steroid alkaloids from the stem bark of Holarrhena pubescens. J. Ethnopharmacol., 1999, 68(1-3), 339-344.
[http://dx.doi.org/10.1016/S0378-8741(99)00119-1] [PMID: 10624899]
[3]
Chusri, S.; Villanueva, I.; Voravuthikunchai, S.P.; Davies, J. Enhancing antibiotic activity: A strategy to control Acinetobacter infections. J. Antimicrob. Chemother., 2009, 64(6), 1203-1211.
[http://dx.doi.org/10.1093/jac/dkp381] [PMID: 19861335]
[4]
Tambekar, D.H.; Dahikar, S.B. Antibacterial activity of some Indian ayurvedic preparations against enteric bacterial pathogens. J. Adv. Pharm. Technol. Res., 2011, 2(1), 24-29.
[http://dx.doi.org/10.4103/2231-4040.79801] [PMID: 22171288]
[5]
Sharma, U.; Velpandian, T.; Sharma, P.; Singh, S. Evaluation of anti-leishmanial activity of selected Indian plants known to have antimicrobial properties. Parasitol. Res., 2009, 105(5), 1287-1293.
[http://dx.doi.org/10.1007/s00436-009-1554-2] [PMID: 19593584]
[6]
Mahato, S.; Mehta, A.; Roy, S. Studies on antibacterial effects of bark, seed and callus extracts of Holarrhena antidysenterica wall. Indian J. Exp. Biol., 2013, 8(2), 717-721.
[7]
Jamadagni, P.; Pawar, S.; Jamadagni, S.; Chougule, S.; Gaidhani, S.; Murthy, S.N. Review of Holarrhena antidysenterica (L.) Wall. ex A. DC.: Pharmacognostic, pharmacological, and toxicological perspective. Pharmacogn. Rev., 2017, 11(22), 141-144.
[http://dx.doi.org/10.4103/phrev.phrev_31_16] [PMID: 28989249]
[8]
Mrinal, S.; Navjeet, S.A. Review on pharmacological aspects of Holarrhena antidysenterica. Sch. Acad. J. Pharm., 2018, 7(12), 488-492.
[http://dx.doi.org/10.21276/sajp.2018.7.12.5]
[9]
Gopinath, G.; Thirumal, M.; Kumar, P.R. Holarrhena antidysenterica Linn. – A Review. Res. J. Pharm. Technol., 2020, 13(4), 2013-2018.
[http://dx.doi.org/10.5958/0974-360X.2020.00362.5]
[10]
Banadawane, D.; Patil, M.; Jadhav, S. Flavonoid rich fraction of Holarrhena antidysenterica Leaves. Attenuate hyperglycemia by ameliorating hyperlipidemia and oxidative stress in type 2 diabetes in rats. Biomed. J. Sci. Tech. Res., 2019, 16(2), 11892-11902.
[http://dx.doi.org/10.26717/BJSTR.2019.16.002821]
[11]
Sinha, S.; Sharma, A.; Reddy, P.H.; Rathi, B.; Prasad, N.V.S.R.K.; Vashishtha, A. Evaluation of phytochemical and pharmacological aspects of Holarrhena antidysenterica (Wall.): A comprehensive review. J. Pharm. Res., 2013, 6(4), 488-492.
[http://dx.doi.org/10.1016/j.jopr.2013.04.004]
[12]
Pradeepa, R.; Mohan, V. The changing scenario of the diabetes epidemic: Implications for India. Indian J. Med. Res., 2002, 116, 121-132.
[PMID: 12674825]
[13]
Bhuiyan, M.M.R.; Bhuiya, N.M.M.A.; Hasan, M.N.; Nahar, U.J. In vivo and in silico evaluation of antinociceptive activities of seed extract from the Holarrhena antidysenterica plant. Heliyon, 2020, 6(5), e03962.
[http://dx.doi.org/10.1016/j.heliyon.2020.e03962] [PMID: 32426548]
[14]
Ali, K.M.; Chatterjee, K.; De, D.; Jana, K.; Bera, T.K.; Ghosh, D. Inhibitory effect of hydro-methanolic extract of seed of Holarrhena antidysenterica on alpha-glucosidase activity and postprandial blood glucose level in normoglycemic rat. J. Ethnopharmacol., 2011, 135(1), 194-196.
[http://dx.doi.org/10.1016/j.jep.2011.02.034] [PMID: 21385604]
[15]
Keshri, U.P.D. Antidiabetic efficacy of ethanolic extract of Holarrhena antidysenterica seeds linn STZ induced diabetic rats and influence on certain biochemical parameters. J. Drug Deliv. Ther., 2012, 2(4), 159-162.
[http://dx.doi.org/10.22270/jddt.v2i4.187]
[16]
Sharma, D.K.; Gupta, V.K.; Kumar, S.; Joshi, V.; Mandal, R.S.K.; Prakash, A.G.B.; Singh, M. Evaluation of antidiarrheal activity of ethanolic extract of Holarrhena antidysenterica seeds in rats. Vet. World, 2015, 8(12), 1392-1395.
[http://dx.doi.org/10.14202/vetworld.2015.1392-1395] [PMID: 27047049]
[17]
Yakub, Sheikh; Vinod Kathait; Rajesh Kumar; Kumar, R. Computation of in-vivo antidiabetic activity of Holarrhena antidysenterica seeds extracts in STZ induced diabetic Rats. Pharmaceuti. Biosci. J., 2013, 1, 11-17.
[http://dx.doi.org/10.20510/ukjpb/1/i1/91106]
[18]
Kumar, S.; Yadav, A. Comparative study of hypoglycaemic effect of Holarrhena antidysenterica seeds and glibenclamide in experimentally induced diabetes mellitus in albino rats. Biomed. Pharmacol. J., 2015, 8(1), 477-483.
[http://dx.doi.org/10.13005/bpj/637]
[19]
Murugan, S.; Purusothaman, D.; Richard, E.J.; Chalichem, N.S.S.; Bethapudi, B.; Chandrasekaran, P.R.; Velusami, C.C.; D’Souza, P.; Mundkinajeddu, D. Anti-diarrhoeal activity of a polyherbal formulation in rats and elucidation of its cellular mechanisms. Avicenna J. Phytomed., 2020, 10(4), 417-427.
[http://dx.doi.org/10.22038/AJP.2019.14339] [PMID: 32850298]
[20]
Kavitha, D.; Shilpa, P.N.; Devaraj, S.N. Antibacterial and antidiarrhoeal effects of alkaloids of Holarrhena antidysenterica WALL. Indian J. Exp. Biol., 2004, 42(6), 589-594.
[PMID: 15260110]
[21]
Singh, V.K.; Ali, Z.A.; Siddiqui, M.K. Medicinal Plants Used by the Forest Ethnics of Gorakhpur District (Uttar Pradesh), India. Int. J. Pharmacog., 1997, 35(3), 194-206.
[http://dx.doi.org/10.1076/phbi.35.3.194.13298]
[22]
Bhusal, A.; Jamarkattel, N.; Shrestha, A.; Lamsal, N.K.; Shakya, S.; Rajbhandari, S. Evaluation of antioxidative and antidiabetic activity of bark of holarrhena pubescens wall. J. Clin. Diagn. Res., 2014, 8(9), HC05-HC08.
[http://dx.doi.org/10.7860/JCDR/2014/7803.4863] [PMID: 25386454]
[23]
Ganapathy, P.S.; Ramachandra, Y.L.; Rai, S.P. In vitro antioxidant activity of Holarrhena antidysenterica Wall. Methanolic leaf extract. J. Basic Clin. Pharm., 2011, 2(4), 175-178.
[PMID: 24826020]
[24]
Anita, P.; Balan, I.N.; Ethiraj, S.; Madan Kumar, P.D.; Sivasamy, S. In vitro antibacterial activity of Camellia sinensis extract against cariogenic microorganisms. J. Basic Clin. Pharm., 2015, 6(1), 35-39.
[http://dx.doi.org/10.4103/0976-0105.145777] [PMID: 25538470]
[25]
Zihadi, M.; Rahman, M.; Talukder, S.; Hasan, M.; Nahar, S.; Sikder, M. Antibacterial efficacy of ethanolic extract of Camellia sinensis and Azadirachta indica leaves on methicillin-resistant Staphylococcus aureus and shiga-toxigenic Escherichia coli. J. Adv. Vet. Anim. Res., 2019, 6(2), 247-252.
[http://dx.doi.org/10.5455/javar.2019.f340] [PMID: 31453199]
[26]
Panda, S.K.; Padhi, L.; Leyssen, P.; Liu, M.; Neyts, J.; Luyten, W. Antimicrobial, anthelmintic, and antiviral activity of plants traditionally used for treating infectious disease in the Similipal biosphere reserve, Odisha, India. Front. Pharmacol., 2017, 8, 658.
[http://dx.doi.org/10.3389/fphar.2017.00658] [PMID: 29109684]
[27]
Shah, S.A.; Usmanghani, K.; Akhtar, N.; Asif, H.M.; Akram, M.; Ahmed, K.; Shaheen, G.; Shamim, T.; Rehman, R.; Ahmad, A.; Sumreen, L. Monograph of Holarrhena antidysenterica (linn.) wall. Phytomedicine, 2010, 2(4), 345-348.
[http://dx.doi.org/10.5138/ijpm.2010.0975.0185.02048]
[28]
Pal, O.R.; Nayak, S.U.; Gupta, R.B. Preliminary clinical study of kutaja (Holarrhena antidysenterica) linn on medodusti W.S.R. to hyperlipidemia. World J. Pharm. Res., 2019, 8, 1242-1247.
[http://dx.doi.org/10.20959/wjpr201913-16319]
[29]
Khan, A.; Khan, S.R.; Gilani, A.H. Studies on the in vitro and in vivo antiurolithic activity of Holarrhena antidysenterica. Urol. Res., 2012, 40(6), 671-681.
[http://dx.doi.org/10.1007/s00240-012-0483-1] [PMID: 22622371]
[30]
Aslam, Khan; Bashir, S.; Gilani, A.H. An in vivo study on the diuretic activity of Holarrhena antidysenterica. Afr. J. Pharm. Pharmacol., 2012, 6(7), 454-458.
[http://dx.doi.org/10.5897/AJPP11.395]
[31]
Patel, M.; Patel, K.; Gupta, S.N. Effects of Ayurvedic treatment on forty-three patients of ulcerative colitis. Ayu, 2010, 31(4), 478-481.
[http://dx.doi.org/10.4103/0974-8520.82046] [PMID: 22048543]
[32]
Paranjpe, P.; Patki, P.; Joshi, N. Efficacy of an indigenous formulation in patients with bleeding piles: A preliminary clinical study. Fitoterapia, 2000, 71(1), 41-45.
[http://dx.doi.org/10.1016/S0367-326X(99)00115-X] [PMID: 11449468]
[33]
Dua, V.K.; Verma, G.; Singh, B.; Rajan, A.; Bagai, U.; Agarwal, D.D.; Gupta, N.C.; Kumar, S.; Rastogi, A. Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica. Malar. J., 2013, 12(1), 194.
[http://dx.doi.org/10.1186/1475-2875-12-194] [PMID: 23758861]
[34]
Verma, G.; Dua, V.K.; Agarwal, D.D.; Atul, P.K. Anti-malarial activity of Holarrhena antidysenterica and Viola canescens, plants traditionally used against malaria in the Garhwal region of north-west Himalaya. Malar. J., 2011, 10(1), 20.
[http://dx.doi.org/10.1186/1475-2875-10-20] [PMID: 21288335]
[35]
Alshawsh, M.A.; Mothana, R.A.; Al-shamahy, H.A.; Alsllami, S.F.; Lindequist, U. Assessment of antimalarial activity against Plasmodium falciparum and phytochemical screening of some Yemeni medicinal plants. Evid. Based Complement. Alternat. Med., 2009, 6(4), 453-456.
[http://dx.doi.org/10.1093/ecam/nem148] [PMID: 18955251]
[36]
Dua, V.K.; Ojha, V.P.; Roy, R.; Joshi, B.C.; Valecha, N.; Devi, C.U.; Bhatnagar, M.C.; Sharma, V.P.; Subbarao, S.K. Anti-malarial activity of some xanthones isolated from the roots of Andrographis paniculata. J. Ethnopharmacol., 2004, 95(2-3), 247-251.
[http://dx.doi.org/10.1016/j.jep.2004.07.008] [PMID: 15507344]
[37]
Lin, J.; Opoku, A.R.; Geheeb-Keller, M.; Hutchings, A.D.; Terblanche, S.E.; Jäger, A.K.; van Staden, J. Preliminary screening of some traditional zulu medicinal plants for anti-inflammatory and anti-microbial activities. J. Ethnopharmacol., 1999, 68(1-3), 267-274.
[http://dx.doi.org/10.1016/S0378-8741(99)00130-0] [PMID: 10624887]
[38]
Somanadhan, B.; Varughese, G.; Palpu, P.; Sreedharan, R.; Gudiksen, L.; Wagner Smitt, U.; Nyman, U. An ethnopharmacological survey for potential angiotensin converting enzyme inhibitors from Indian medicinal plants. J. Ethnopharmacol., 1999, 65(2), 103-112.
[http://dx.doi.org/10.1016/S0378-8741(98)00201-3] [PMID: 10465650]
[39]
Ahmad, I.; Beg, A.Z. Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogens. J. Ethnopharmacol., 2001, 74(2), 113-123.
[http://dx.doi.org/10.1016/S0378-8741(00)00335-4] [PMID: 11167029]
[40]
Maiti, R.; Das, U.K.; Ghosh, D. Attenuation of hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats by aqueous extract of seed of Tamarindus indica. Biol. Pharm. Bull., 2005, 28(7), 1172-1176.
[http://dx.doi.org/10.1248/bpb.28.1172] [PMID: 15997092]
[41]
Ronge, H.; Blum, L.W. Somatomedin C and other hormones in dairy cow around parturition in newborn calves and milk. J. Appl. Anim. Nutr., 1998, 60, 168-176.
[http://dx.doi.org/10.1017/S000335610000324X]
[42]
Shwetha, C.; Latha, K.P.; Asha, K. A study on analgesic activity of Holarrhena antidysenterica leaves. Int. J. Integr. Med., 2014, 2(3), 14-16.
[http://dx.doi.org/10.5694/j.1326-5377.2000.tb125548.x]
[43]
Nakalembe, L.; Kasolo, J.N.; Nyatia, E.; Lubega, A.; Bbosa, G.S. Analgesic and anti-inflammatory activity of total crude leaf extract of Phytolacca dodecandra in wistar albino rats. Neurosci. Med., 2019, 10(3), 259-271.
[http://dx.doi.org/10.4236/nm.2019.103020]
[44]
Chusri, S.; Na-Phatthalung, P.; Siriyong, T.; Paosen, S.; Voravuthikunchai, S.P. Holarrhena antidysenterica as a resistance modifying agent against Acinetobacter baumannii: Its effects on bacterial outer membrane permeability and efflux pumps. Microbiol. Res., 2014, 169(5-6), 417-424.
[http://dx.doi.org/10.1016/j.micres.2013.09.004] [PMID: 24103863]
[45]
Sharma, V.; Hussain, S.; Bakshi, M.; Bhat, N.; Saxena, A.K. In vitro cytotoxic activity of leaves extracts of Holarrhena antidysenterica against some human cancer cell lines. Indian J. Biochem. Biophys., 2014, 51(1), 46-51.
[PMID: 24791416]
[46]
Hegde, K.; Thakker, S.P.; Joshi, A.B.; Shastry, C.S.; Chandrashekhar, K.S. Anticovusant activity of Carissa carandas linn. root extract in experimental mice. Trop. J. Pharm. Res., 2009, 8(2), 117-125.
[http://dx.doi.org/10.4314/tjpr.v8i2.44519]
[47]
Verma, P.; Srivastava, S.; Rao, C.V. Hepatoprotective effect of ethanolic extract of Holarrhena antidysenterica against paracetamol induced toxicity in wistar rats. Res J. Pharm. Tech., 2018, 11(4), 1633-1639.
[http://dx.doi.org/10.5958/0974-360X.2018.00304.9]
[48]
Kumar, B.; Vijayakumar, M.; Govindarajan, R.; Pushpangadan, P. Ethnopharmacological approaches to wound healing—Exploring medicinal plants of India. J. Ethnopharmacol., 2007, 114(2), 103-113.
[http://dx.doi.org/10.1016/j.jep.2007.08.010] [PMID: 17884316]
[49]
Nahar, U.J.; Bhuiyan, M.M.R.; Amsudduzah, A.N.M.; Uddin, M.R.; Maryam, Z. Phytochemical screening, cytotoxic and CNS dependent activities of Holarrhena antidysenterica of leaves and seeds. Int. J. Pharm. Sci. Res., 2015, 6(2), 620-623.
[http://dx.doi.org/10.13040/IJPSR.0975-8232.6(2).620-23]
[50]
Kebede, B.; Shibeshi, W. In vitro antibacterial and antifungal activities of extracts and fractions of leaves of Ricinus communis Linn against selected pathogens. Vet. Med. Sci., 2022, 8(4), 1802-1815.
[http://dx.doi.org/10.1002/vms3.772] [PMID: 35182460]
[51]
Nahar, U.J.; Akter, M.; Bhuiyan, M.M.R.; Rahmatullah, M. Evaluation of analgesic activity of methanolic extract of Holarrhena antidysenterica leaves by tail immersion and hot plate assay methods. World J. Pharm. Res., 2017, 7, 172-178.
[http://dx.doi.org/10.20959/wjpr20181-10490]
[52]
Rath, S.; Padhy, R.N. Monitoring iin vitro efficacy of Holarrhena antidysenterica against multidrug resistant enteropathogenic bacteria. Asian Pac. J. Trop. Dis., 2014, 4, S54-S63.
[http://dx.doi.org/10.1016/S2222-1808(14)60415-1]

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