Neuropsychiatric Symptoms are Related to Blood-biomarkers in Major
Neurocognitive Disorders

Inês      Marques-Aleixo; Arnaldina      Sampaio; Lucimére      Bohn; Flavia      Machado; Duarte      Barros; Oscár      Ribeiro; Joana      Carvalho; José      Magalhães

doi:10.2174/1874609816666230816090934

Abstract

Background: Neuropsychiatric symptoms (NPS) are highly prevalent among individuals with major neurocognitive disorders (MNCD). Objective: Here, we characterized blood biomarkers (metabolic, inflammatory, neurotrophic profiles and total antioxidant), body composition, physical fitness and quality of life (QoL) in individuals with MNCD according to NPS.

Methods: The sample comprised 34 older adults (71.4% women; 74.06±6.03 yrs, with MNCD diagnosis) categorized according to 50th percentile [Low (≤12) or High (≥13)] for NPS (Neuropsychiatric Inventory Questionnaire). Sociodemographic, clinical data, body composition, anthropometric, cognitive assessment (ADAS-Cog), physical fitness (Senior Fitness Test), QoL (QoL-Alzheimer’s Disease scale) were evaluated, and blood samples were collected for biochemical analysis.

Results: Low compared to high NPS group showed higher levels of IL-6, IGF-1and neurotrophic zscore (composite of IGF-1, VEGF-1, BDNF). Additionally, low compared to high NPS group have higher QoL, aerobic fitness and upper body and lower body strength.

Conclusion: The severity of NPS seems to be related to modified neurotrophic and inflammatory outcomes, lower physical fitness, and poor QoL. Strategies to counteract NPS development may preserve the physical and mental health of individuals with MNCD.

Keywords: Blood biomarkers, alzheimer disease, dementia, neuropsychiatric inventory questionnaire, seniors, neuropsychiatric symptoms (NPS), MNCD.

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DOI https://dx.doi.org/10.2174/1874609816666230816090934	Print ISSN 1874-6098
Publisher Name Bentham Science Publisher	Online ISSN 1874-6128

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Neuropsychiatric Symptoms are Related to Blood-biomarkers in Major Neurocognitive Disorders

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