Title:A Pilot Study of Anlotinib as a Combination Treatment in Advanced
Nasopharyngeal Carcinoma
Volume: 24
Issue: 3
关键词:
鼻咽癌,安罗替尼,化疗,疗效,安全性,免疫治疗。
摘要:
Aims: To investigate the short-term objective response and treatment toxicity of anlotinib as a
combination treatment in patients with Recurrent or Metastatic Nasopharyngeal Carcinoma (RM-NPC).
Methods: Patients with RM-NPC who received anlotinib as a combination treatment between March
2021 and July 2022 were retrospectively analyzed.The efficacy and safety of anlotinib as a combination
treatment were analyzed.
Results: A total of 17 patients with RM-NPC were included in this study. Of these patients, 2 (11.8%)
had local recurrence, 4 (23.5%) had cervical lymph node recurrence, and 11 (64.9%) had distant failure.
The most common metastatic site was the liver (47.1%), followed by the lung (23.5%) and bone
(23.5%). Anlotinib was given as first-line treatment in 3 patients (17.6%), second lines treatment in 7
patients (41.2%), and third to six-lines treatment in 7 patients (41.2%). All patients received anlotinib
combined with chemotherapy and/or immunotherapy. One patient achieved a complete response (5.9%),
7 patients had a partial response (41.2%), 5 patients had stable disease (29.4%), and 4 patients had progressive
disease (23.5%). The overall disease control rate and the overall response rate were 76.5% and
47.1%, respectively. The median progression-free survival was 8.1 months, and the median overall survival
was not reached. The incidence of grade 3 adverse events was 30%. No unexpected side effects or
treatment-related death were observed.
Conclusion: Anlotinib, as a combination treatment, has a promising antitumor activity and a manageable
safety profile in patients with RM-NPC. Our results add to the growing evidence that supports the
benefits of combining antiangiogenic drugs in RM-NPC. Randomized controlled clinical trials investigating
the evaluation of anlotinib are warranted.