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Mini-Review Article

Dietary Phytoactives in the Management of Gastric Cancer - A Mini Review

Author(s): Vivek Sharma*, Mahendra Singh Ashawat and Pravin Kumar

Volume 19, Issue 4, 2024

Published on: 22 August, 2023

Page: [376 - 384] Pages: 9

DOI: 10.2174/1574885518666230809121536

Price: $65

Abstract

Gastric cancer is the fourth leading cause of morbidity worldwide and is known to affect various gastric organs, including the esophagus, intestine, colon, and pancreas. There are variable factors responsible for the development of gastric tumors, such as environmental factors, EPV, hepatitis B and C, and other genetic factors. Phytoactives, or secondary metabolites of plants, have a wide range of biological impacts, including the capacity to prevent cancer in humans. They have this anticancerous impact because of their multi-target mechanism of action, which also includes antioxidant, anti-proliferative, cell apoptosis, and anti-mutagenic effects. To epitomize the role of vital dietary phytoactives as a new approach for treating gastric cancer and explains various mechanisms for their anticancerous activity. H. pylori-associated gastric tumors are the most common, and Phytoactives such as curcumin, piperine, walnut oil, tea, and others possess anticancer properties. They have shown anticancer activity against gastric tumor cell lines via different mechanisms like cell cycle arrest, apoptosis, inhibition of cell proliferation, adhesion, colonization of cancer cells, inhibition of inflammatory mediators, tumor cell bioenergetics, up and down-regulation of various gene and protein expression, and chelation and scavenging of ROS.

Keywords: Gastric cancer, phytoconstituents, phytochemicals, bioactives, anti-cancerous, H. pylori, ROS.

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