Title:Amphotericin-B-Induced Chronic Kidney Disease in a Post-COVID-19
Patient with Widespread Rhinocerebral Mucormycosis and Pneumonia:
A Case Report
Volume: 19
Issue: 4
Author(s): Nishant Johri*, Ambika Choudhary, Ujjawal Rawat and Maheshwari Vengat
Affiliation:
- Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, Moradabad, Uttar Pradesh, India
- Department of Pharmacy Practice, Teerthanker Mahaveer Hospital & Research Centre, Moradabad, Uttar Pradesh,
India
Keywords:
Mucormycosis, amphotericin B, chronic kidney disease, chronic obstructive pulmonary disease, pneumonia, COVID-19.
Abstract:
Background: The COVID-19 pandemic has posed a unique challenge to the medical
community due to potential co-infections with bacteria and fungi. We report a case of Rhino
cerebral mucormycosis infection in a 67-year-old patient after recovery from COVID-19.
Objective: To report a case of Rhino cerebral mucormycosis in a 67-year-old patient with preexisting
health conditions after recovering from COVID-19 and to highlight the importance of early
detection and treatment of co-infections in patients with pre-existing health conditions.
Case Presentation: The patient had pre-existing health conditions, including uncontrolled diabetes,
hypertension, and Chronic obstructive pulmonary disease (COPD), which made him more vulnerable
to complications after COVID-19. He was admitted to the hospital after experiencing a dark
discharge from his left eye, later confirmed to be due to mucormycosis. Histopathological examination
revealed invasive mucormycosis, highlighting the importance of early detection and treatment.
However, the patient experienced Acute kidney injury (AKI) after only 5 days of treatment
with conventional amphotericin B, underscoring the need for careful monitoring and adjustment of
treatment regimens.
Discussion: The case underscores the need for early detection and treatment of co-infections in
vulnerable patients. The patient's pre-existing conditions and immunocompromised state made him
more susceptible to the infection. The case also highlights the importance of careful monitoring
and adjustment of treatment regimens to minimize the risk of adverse effects.
Conclusion: While COVID-19 has presented challenges and uncertainties, it has also provided
valuable insights into the interactions between infectious agents and the human body. Continued
research and vigilance are necessary to mitigate the impact of co-infections and improve outcomes
for patients.
