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Abstract
Background: Argania spinosa L. seed oil is a Moroccan endemic product that is used traditionally as an alternative treatment for diabetes.
Objective: The present work aims to evaluate the hemoglobin antiglycation and the antioxidant effect of roasted (Roil) and unroasted (UnRoil) Argan seed oil in vitro.
Methods: The antioxidant activity was evaluated by different methods (total antioxidant capacity by the ammonium molybdate, metal chelating activity, ferric reducing antioxidant power, 1, 1-diphenyl- 2- picrylhydrazyl free radical scavenging, and β-carotene bleaching test), and the protein antiglycation effect was tested using hemoglobin, in vitro.
Results: The results showed that both oils possess an important antioxidant effect and the roasting process did not influence the total antioxidant capacity, metal chelating activity, and β-carotene bleaching test. Although, it significantly influences the antiradical activity of Argania spinosa L. seed oil (p < 0.05) with IC50 values of 21.47 ± 0.076 μg/mL for Roil and 4.01 ± 1.13 μg/mL for UnRoil. Besides, Roil and UnRoil it significantly inhibit the hemoglobin glycation activity, with IC50 values of 1.09 ± 0.31 and 0.16 ± 0.031 mg/ml respectively. Moreover, it was noted that UnRoil has a lower IC50 value than Roil, which means that UnRoil has a more potent activity than Roil (p < 0.05).
Conclusion: Argania spinosa L. seed oil is an essential source of natural antioxidants and hemoglobin antiglycation that plays a key role in scavenging of free radicals and might be used for reducing the development of diabetic complications.
Keywords: Diabetes, Argania spinosa, roasting process, protein glycation, hemoglobin antiglycation, antioxidant, in vitro.
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