Title:Antidiabetic and Antidyslipidemic Effects of Artemisia mesatlantica, an
Endemic Plant from Morocco
Volume: 23
Issue: 1
Author(s): Adil Qabouche, Ayoub Amssayef, Ismail Bouadid, Nadia Lahrach, Ahmed EL-Haidani and Mohamed Eddouks*
Affiliation:
- Team of Ethnopharmacology and Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail
University of Meknes, BP 509, Boutalamine, Errachidia, 52000, Morocco
Keywords:
Artemisia mesatlantica, antidiabetic effect, antidyslipidemic effect, streptozotocin, triton-WR-1339.
Abstract:
Aims: The study aimed to assess the antihyperglycemic and antidyslipidemic activities of
Artemisia mesatlantica.
Background: Artemisia mesatlantica is an endemic plant of Morocco used in traditional medicine
as an alternative treatment for diabetes.
Objective: The study was designed to examine the antihyperglycemic and antidyslipidemicability of
aqueous extract of Artemisia mesatlantica (AMAE) in experimental animal models.
Methods: The effect of the single and repeated oral administration (7 days of treatment) of AMAE
(60 mg/kg) on blood glucose and lipid profile were assessed in normal and streptozotocin-induced
diabetic rats. Furthermore, to confirm the antidyslipidemic effect of Artemisia mesatlantica, a model
of hyperlipidemia induced by tyloxapol (Triton WR-1339) in rats was used.
Results: The AMAE (60 mg/kg) was able to significantly reduce glycaemia, improve lipid profile
and increase hepatic glycogen content in STZ-induced diabetic rats. In addition, pretreatment of rats
for 7 consecutive days with an aqueous extract of Artemisia mesatlantica (600 mg/kg) prior to tyloxapol
injection prevented increases in plasma levels of total cholesterol, triglycerides and LDL-c.
Conclusion: From these observed results, it can be deduced that Artemisia mesatlantica possesses
remarkable antidiabetic and antihyperlipidemic properties.
