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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

Current State of Lipid Nanoparticles (SLN and NLC) for Skin Applications

Author(s): Cemre Eroğlu, Genada Sinani and Zeynep Ulker*

Volume 29, Issue 21, 2023

Published on: 04 August, 2023

Page: [1632 - 1644] Pages: 13

DOI: 10.2174/1381612829666230803111120

Price: $65

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Abstract

The increasing knowledge on skin physiology, formulation science and nanotechnology has led to continuous improvements in cosmetics, and introduction of dermocosmetics has been increasing particularly for the management of skin disorders such as acne, eczema, psoriasis, etc. Nowadays, research has been focused on the development of products which can efficiently administer active compounds to the target skin layers while minimizing side effects. The use of multifunctional lipid nanoparticles for cosmetic and dermocosmetic purposes is promising not only because biocompatible ingredients are used in their composition, but also because of their ability to show enhanced skin penetration. Although the introduction of liposomes has been a hallmark of lipid nanoparticles, development of novel systems capable of encapsulating active compounds with tunable release profiles, that show good stability, are easy to manufacture and handle remains a necessity. Solid lipid nanoparticles (SLN) were introduced as alternative formulations for emulsions, liposomes and polymeric nanoparticles, whereas nanostructured lipid carriers (NLC) were developed later as second-generation nanoparticles. However, both SLN and NLC show many inherited advantageous properties to be used for dermal applications including ability to provide occlusion and photoprotective effect and skin hydration, and various SLN and NLC based products are already in the market. This review provides an overview on the current state-of-art of SLN and NLC particularly for cosmetic and dermocosmetic purposes, discuss their formulation composition, structures and preparation techniques. Their use for the topical delivery of active compounds in different skin disorders is highlighted along with examples of commercialized products.

Keywords: Lipid nanoparticles, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), cosmetics, dermocosmetics, topical, skin.

« Previous Next »
[1]
Food and Drug Administration. How does the law define a cosmetic? 2022. Available from:https://www.fda.gov/cosmetics/cosmetics-labeling-regulations/summary-cosmetics-labeling-requirements#Legal
[2]
Dreno B, Araviiskaia E, Berardesca E, et al. The science of dermocosmetics and its role in dermatology. J Eur Acad Dermatol Venereol 2014; 28(11): 1409-17.
[http://dx.doi.org/10.1111/jdv.12497] [PMID: 24684296]
[3]
Jain S, Puri R. Development, characterization and in vivo localization study of topical 5-fluorouracil gels: A comparative study with conventional formulation. Curr Drug Deliv 2014; 11(3): 401-14.
[http://dx.doi.org/10.2174/1567201810666131210112150] [PMID: 24328603]
[4]
Arora N, Agarwal S, Murthy RSR. Latest technology advances in cosmaceuticals. Int J Pharm Sci Drug Res 2012; 4: 168-82.
[5]
Padamwar M, Pokharkar V. Development of vitamin loaded topical liposomal formulation using factorial design approach: Drug deposition and stability. Int J Pharm 2006; 320(1-2): 37-44.
[http://dx.doi.org/10.1016/j.ijpharm.2006.04.001] [PMID: 16707237]
[6]
Sharma A, Sharma US. Liposomes in drug delivery: Progress and limitations. Int J Pharm 1997; 154(2): 123-40.
[http://dx.doi.org/10.1016/S0378-5173(97)00135-X]
[7]
Shidhaye S, Vaidya R, Sutar S, Patwardhan A, Kadam V. Solid lipid nanoparticles and nanostructured lipid carriers-innovative generations of solid lipid carriers. Curr Drug Deliv 2008; 5(4): 324-31.
[http://dx.doi.org/10.2174/156720108785915087] [PMID: 18855604]
[8]
Patel D, Tripathy S, Kesharwani R. Nanostructured lipid carrier (NLC): A modern approach for transdermal drug delivery. World J Pharm Pharm Sci 2013; 2: 921-38.
[http://dx.doi.org/10.5958/0974-360X.2017.00493.0]
[9]
Müller RH, Mäder K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery - A review of the state of the art. Eur J Pharm Biopharm 2000; 50(1): 161-77.
[http://dx.doi.org/10.1016/S0939-6411(00)00087-4] [PMID: 10840199]
[10]
Chauhan I, Yasir M, Verma M, Singh AP. Nanostructured lipid carriers: A groundbreaking approach for transdermal drug delivery. Adv Pharm Bull 2020; 10(2): 150-65.
[http://dx.doi.org/10.34172/apb.2020.021] [PMID: 32373485]
[11]
Müller RH, Radtke M, Wissing SA. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv Rev 2002; 54(Suppl. 1): S131-55.
[http://dx.doi.org/10.1016/S0169-409X(02)00118-7] [PMID: 12460720]
[12]
Souto EB, Baldim I, Oliveira WP, et al. SLN and NLC for topical, dermal, and transdermal drug delivery. Expert Opin Drug Deliv 2020; 17(3): 357-77.
[http://dx.doi.org/10.1080/17425247.2020.1727883] [PMID: 32064958]
[13]
Pardeike J, Hommoss A, Müller RH. Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products. Int J Pharm 2009; 366(1-2): 170-84.
[http://dx.doi.org/10.1016/j.ijpharm.2008.10.003] [PMID: 18992314]
[14]
Belokhvostova D, Berzanskyte I, Cujba AM, et al. Homeostasis, regeneration and tumour formation in the mammalian epidermis. Int J Dev Biol 2018; 62(6-7-8): 571-82.
[http://dx.doi.org/10.1387/ijdb.170341fw] [PMID: 29938768]
[15]
Bahamonde-Norambuena D, Molina-Pereira A, Cantin M, Muñoz M, Zepeda K, Vilos C. Polymeric nanoparticles in dermocosmetic. Int J Morphol 2015; 33(4): 1563-8.
[http://dx.doi.org/10.4067/S0717-95022015000400061]
[16]
Mukherjee S, Ray S, Thakur RS. Solid lipid nanoparticles: A modern formulation approach in drug delivery system. Indian J Pharm Sci 2009; 71(4): 349-58.
[http://dx.doi.org/10.4103/0250-474X.57282] [PMID: 20502539]
[17]
Javed S, Mangla B, Almoshari Y, Sultan MH, Ahsan W. Nanostructured lipid carrier system: A compendium of their formulation development approaches, optimization strategies by quality by design, and recent applications in drug delivery. Nanotechnol Rev 2022; 11(1): 1744-77.
[http://dx.doi.org/10.1515/ntrev-2022-0109]
[18]
Lim SB, Banerjee A, Önyüksel H. Improvement of drug safety by the use of lipid-based nanocarriers. J Control Release 2012; 163(1): 34-45.
[http://dx.doi.org/10.1016/j.jconrel.2012.06.002] [PMID: 22698939]
[19]
Koo OM, Rubinstein I, Önyüksel H. Role of nanotechnology in targeted drug delivery and imaging: A concise review. Nanomedicine 2005; 1(3): 193-212.
[http://dx.doi.org/10.1016/j.nano.2005.06.004] [PMID: 17292079]
[20]
Cevc G. Phospholipids Handbook. (1st ed.). Boca Raton: CRC Press 1993; p. 1004.
[http://dx.doi.org/10.1201/9780203743577]
[21]
Müller RH, Souto EB, Go¨ppert T, Gohl S. Production of biofunctionalized solid lipid nanoparticles for site-specific drug delivery. Nanotechnologies for the Life Sciences. Wiley Online Library 2007.
[22]
Müller R, Maassen S, Weyhers H, Specht F, Lucks J. Cytotoxicity of magnetite-loaded polylactide, polylactide/glycolide particles and solid lipid nanoparticles. Int J Pharm 1996; 138(1): 85-94.
[http://dx.doi.org/10.1016/0378-5173(96)04539-5]
[23]
Mishra V, Bansal K, Verma A, et al. Solid lipid nanoparticles: Emerging colloidal nano drug delivery systems. Pharmaceutics 2018; 10(4): 191.
[http://dx.doi.org/10.3390/pharmaceutics10040191] [PMID: 30340327]
[24]
Manjunath K, Reddy JS, Venkateswarlu V. Solid lipid nanoparticles as drug delivery systems. Methods Find Exp Clin Pharmacol 2005; 27(2): 127-44.
[http://dx.doi.org/10.1358/mf.2005.27.2.876286] [PMID: 15834465]
[25]
Wissing SA, Kayser O, Müller RH. Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev 2004; 56(9): 1257-72.
[http://dx.doi.org/10.1016/j.addr.2003.12.002] [PMID: 15109768]
[26]
Beloqui A, Solinís MÁ, Rodríguez-Gascón A, Almeida AJ, Préat V. Nanostructured lipid carriers: Promising drug delivery systems for future clinics. Nanomedicine 2016; 12(1): 143-61.
[http://dx.doi.org/10.1016/j.nano.2015.09.004] [PMID: 26410277]
[27]
Müller RH, Radtke M, Wissing SA. Nanostructured lipid matrices for improved microencapsulation of drugs. Int J Pharm 2002; 242(1-2): 121-8.
[http://dx.doi.org/10.1016/S0378-5173(02)00180-1] [PMID: 12176234]
[28]
Martins S, Sarmento B, Ferreira DC, Souto EB. Lipid-based colloidal carriers for peptide and protein delivery-liposomes versus lipid nanoparticles. Int J Nanomedicine 2007; 2(4): 595-607.
[PMID: 18203427]
[29]
Liang R, Wang Y, Wu L, Ni X, Yang C. Quaternized chitosan modified nanostructure lipid carriers for topical delivery of coenzyme Q10. Nano Life 2020; 10(4): 2040013.
[http://dx.doi.org/10.1142/S1793984420400139]
[30]
Teeranachaideekul V, Müller R, Junyaprasert V. Encapsulation of ascorbyl palmitate in nanostructured lipid carriers (NLC)-effects of formulation parameters on physicochemical stability. Int J Pharm 2007; 340(1-2): 198-206.
[http://dx.doi.org/10.1016/j.ijpharm.2007.03.022] [PMID: 17482778]
[31]
Morales JO, Valdés K, Morales J, Oyarzun-Ampuero F. Lipid nanoparticles for the topical delivery of retinoids and derivatives. Nanomedicine 2015; 10(2): 253-69.
[http://dx.doi.org/10.2217/nnm.14.159] [PMID: 25600970]
[32]
Sharma G, Thakur K, Raza K, Singh B, Katare OP. Nanostructured lipid carriers: A new paradigm in topical delivery for dermal and transdermal applications. Crit Rev Ther Drug Carrier Syst 2017; 34(4): 355-86.
[http://dx.doi.org/10.1615/CritRevTherDrugCarrierSyst.2017019047] [PMID: 29199589]
[33]
Wu X, Guy RH. Applications of nanoparticles in topical drug delivery and in cosmetics. J Drug Deliv Sci Technol 2009; 19(6): 371-84.
[http://dx.doi.org/10.1016/S1773-2247(09)50080-9]
[34]
Schubert MA, Müller-Goymann CC. Characterisation of surface- modified solid lipid nanoparticles (SLN): Influence of lecithin and nonionic emulsifier. Eur J Pharm Biopharm 2005; 61(1-2): 77-86.
[http://dx.doi.org/10.1016/j.ejpb.2005.03.006] [PMID: 16011893]
[35]
Naseri N, Valizadeh H, Zakeri-Milani P. Solid lipid nanoparticles and nanostructured lipid carriers: Structure, preparation and application. Adv Pharm Bull 2015; 5(3): 305-13.
[http://dx.doi.org/10.15171/apb.2015.043] [PMID: 26504751]
[36]
Jenning V, Lippacher A, Gohla SH. Medium scale production of solid lipid nanoparticles (SLN) by high pressure homogenization. J Microencapsul 2002; 19(1): 1-10.
[http://dx.doi.org/10.1080/713817583] [PMID: 11811751]
[37]
Dingler A, Gohla S. Production of solid lipid nanoparticles (SLN): Scaling up feasibilities. J Microencapsul 2002; 19(1): 11-6.
[http://dx.doi.org/10.1080/02652040010018056] [PMID: 11811752]
[38]
Ugazio E, Cavalli R, Gasco MR. Incorporation of cyclosporin A in solid lipid nanoparticles (SLN). Int J Pharm 2002; 241(2): 341-4.
[http://dx.doi.org/10.1016/S0378-5173(02)00268-5] [PMID: 12100861]
[39]
Trotta M, Debernardi F, Caputo O. Preparation of solid lipid nanoparticles by a solvent emulsification-diffusion technique. Int J Pharm 2003; 257(1-2): 153-60.
[http://dx.doi.org/10.1016/S0378-5173(03)00135-2] [PMID: 12711170]
[40]
Garud A, Singh D, Garud N. Solid Lipid Nanoparticles (SLN): Method, characterization and applications. Int Curr Pharm J 2012; 1(11): 384-93.
[http://dx.doi.org/10.3329/icpj.v1i11.12065]
[41]
Mehnert W, Mäder K. Solid lipid nanoparticles production, characterization and applications. Adv Drug Deliv Rev 2001; 47(2-3): 165-96.
[http://dx.doi.org/10.1016/S0169-409X(01)00105-3] [PMID: 11311991]
[42]
Gordillo-Galeano A, Mora-Huertas CE. Solid lipid nanoparticles and nanostructured lipid carriers: A review emphasizing on particle structure and drug release. Eur J Pharm Biopharm 2018; 133: 285-308.
[http://dx.doi.org/10.1016/j.ejpb.2018.10.017] [PMID: 30463794]
[43]
Saupe A, Gordon KC, Rades T. Structural investigations on nanoemulsions, solid lipid nanoparticles and nanostructured lipid carriers by cryo-field emission scanning electron microscopy and Raman spectroscopy. Int J Pharm 2006; 314(1): 56-62.
[http://dx.doi.org/10.1016/j.ijpharm.2006.01.022] [PMID: 16574354]
[44]
Jenning V, Thünemann AF, Gohla SH. Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids. Int J Pharm 2000; 199(2): 167-77.
[http://dx.doi.org/10.1016/S0378-5173(00)00378-1] [PMID: 10802410]
[45]
Ezzati Nazhad Dolatabadi J, Valizadeh H, Hamishehkar H. Solid lipid nanoparticles as efficient drug and gene delivery systems: Recent breakthroughs. Adv Pharm Bull 2015; 5(2): 151-9.
[http://dx.doi.org/10.15171/apb.2015.022] [PMID: 26236652]
[46]
Parhi R, Suresh P. Preparation and characterization of solid lipid nanoparticles-a review. Curr Drug Discov Technol 2012; 9(1): 2-16.
[http://dx.doi.org/10.2174/157016312799304552] [PMID: 22235925]
[47]
Radtke M, Souto EB, Müller RH. Nanostructured lipid carriers. a novel generation of solid lipid drug carriers. Pharm Technol Eur 2005; 17: 45-50.
[48]
Yuan H, Wang LL, Du YZ, You J, Hu FQ, Zeng S. Preparation and characteristics of nanostructured lipid carriers for control-releasing progesterone by melt-emulsification. Colloids Surf B Biointerfaces 2007; 60(2): 174-9.
[http://dx.doi.org/10.1016/j.colsurfb.2007.06.011] [PMID: 17656075]
[49]
Jensen LB, Petersson K, Nielsen HM. In vitro penetration properties of solid lipid nanoparticles in intact and barrier-impaired skin. Eur J Pharm Biopharm 2011; 79(1): 68-75.
[http://dx.doi.org/10.1016/j.ejpb.2011.05.012] [PMID: 21664463]
[50]
Desai P, Patlolla RR, Singh M. Interaction of nanoparticles and cell-penetrating peptides with skin for transdermal drug delivery. Mol Membr Biol 2010; 27(7): 247-59.
[http://dx.doi.org/10.3109/09687688.2010.522203] [PMID: 21028936]
[51]
Sala M, Diab R, Elaissari A, Fessi H. Lipid nanocarriers as skin drug delivery systems: Properties, mechanisms of skin interactions and medical applications. Int J Pharm 2018; 535(1-2): 1-17.
[http://dx.doi.org/10.1016/j.ijpharm.2017.10.046] [PMID: 29111097]
[52]
López-García R, Ganem-Rondero A. Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC): Occlusive Effect and Penetration Enhancement Ability. J Cosmetics, Dermatol Sci App 2015; 5(2): 62-72.
[http://dx.doi.org/10.4236/jcdsa.2015.52008]
[53]
Dingler A, Hildebrand G, Niehus H, Müller R. Cosmetic anti-aging formulation based on vitamin E-loaded solid lipid nanoparticles. Proc Int Symp Control Release Bioact Mater 1998; 25: 433-4.
[54]
De Vringer T, De Ronde HAG. Preparation and structure of a water-in-oil cream containing lipid nanoparticles. J Pharm Sci 1995; 84(4): 466-72.
[http://dx.doi.org/10.1002/jps.2600840415] [PMID: 7629738]
[55]
Souto EB, Wissing SA, Barbosa CM, Müller RH. Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery. Int J Pharm 2004; 278(1): 71-7.
[http://dx.doi.org/10.1016/j.ijpharm.2004.02.032] [PMID: 15158950]
[56]
Loo Ch, Basri M, Ismail R, et al. Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion. Int J Nanomedicine 2012; 8: 13-22.
[http://dx.doi.org/10.2147/IJN.S35648] [PMID: 23293516]
[57]
Montenegro L, Parenti C, Turnaturi R, Pasquinucci L. Resveratrol-loaded lipid nanocarriers: Correlation between in vitro occlusion factor and in vivo skin hydrating effect. Pharmaceutics 2017; 9(4): 58.
[http://dx.doi.org/10.3390/pharmaceutics9040058] [PMID: 29232856]
[58]
Teeranachaideekul V, Boonme P, Souto EB, Müller RH, Junyaprasert VB. Influence of oil content on physicochemical properties and skin distribution of Nile red-loaded NLC. J Control Release 2008; 128(2): 134-41.
[http://dx.doi.org/10.1016/j.jconrel.2008.02.011] [PMID: 18423768]
[59]
Song A, Zhang X, Li Y, Mao X, Han F. Effect of liquid-to-solid lipid ratio on characterizations of flurbiprofen-loaded solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) for transdermal administration. Drug Dev Ind Pharm 2016; 42(8): 1308-14.
[http://dx.doi.org/10.3109/03639045.2015.1132226] [PMID: 26707734]
[60]
Abou-Dahech M, Boddu SHS, Bachu DR, et al. A mini-review on limitations associated with UV filters. Arab J Chem 2022; 15(11): 104212.
[http://dx.doi.org/10.1016/j.arabjc.2022.104212]
[61]
Müller R, Wissing S, Mäder K. UV radiation reflecting or absorbing agents, protecting against harmful UV radiation and reinforcing the natural skin barrier. US Patent 6814959B1, 2000.
[62]
Souto EB, Müller RH. Cosmetic features and applications of lipid nanoparticles (SLN®, NLC®). Int J Cosmet Sci 2008; 30(3): 157-65.
[http://dx.doi.org/10.1111/j.1468-2494.2008.00433.x] [PMID: 18452432]
[63]
Sanad RA, AbdelMalak NS, elBayoomy TS, Badawi AA. Formulation of a novel oxybenzone-loaded nanostructured lipid carriers (NLCs). AAPS PharmSciTech 2010; 11(4): 1684-94.
[http://dx.doi.org/10.1208/s12249-010-9553-2] [PMID: 21107771]
[64]
Nesseem D. Formulation of sunscreens with enhancement sun protection factor response based on solid lipid nanoparticles. Int J Cosmet Sci 2011; 33(1): 70-9.
[http://dx.doi.org/10.1111/j.1468-2494.2010.00598.x] [PMID: 20704600]
[65]
Lee YJ, Nam GW. Sunscreen boosting effect by solid lipid nanoparticles-loaded fucoxanthin formulation. Cosmetics 2020; 7(1): 14.
[http://dx.doi.org/10.3390/cosmetics7010014]
[66]
do Prado AH, Araújo VHS, Eloy JO, et al. Synthesis and characterization of nanostructured lipid nanocarriers for enhanced sun protection factor of Octyl p-methoxycinnamate. AAPS PharmSciTech 2020; 21(4): 125.
[http://dx.doi.org/10.1208/s12249-019-1547-0] [PMID: 32350635]
[67]
Langton AK, Sherratt MJ, Griffiths CEM, Watson REB. Review article: A new wrinkle on old skin: The role of elastic fibres in skin ageing. Int J Cosmet Sci 2010; 32(5): 330-9.
[http://dx.doi.org/10.1111/j.1468-2494.2010.00574.x] [PMID: 20572890]
[68]
Żerańska J, Pasikowska M, Szczepanik B, et al. A study of the activity and effectiveness of recombinant fibroblast growth factor (Q40P/S47I/H93G rFGF-1) in anti-aging treatment. Postepy Dermatol Alergol 2016; 1(1): 28-36.
[http://dx.doi.org/10.5114/pdia.2014.44024] [PMID: 26985176]
[69]
Jeon HS, Seo JE, Kim MS, et al. A retinyl palmitate-loaded solid lipid nanoparticle system: Effect of surface modification with dicetyl phosphate on skin permeation in vitro and anti-wrinkle effect in vivo. Int J Pharm 2013; 452(1-2): 311-20.
[http://dx.doi.org/10.1016/j.ijpharm.2013.05.023] [PMID: 23702002]
[70]
Kim M, Kim K, Sohn S, et al. Formulation and evaluation of nanostructured lipid carriers (NLCs) of 20 (S)-Protopanaxadiol (PPD). By Box-Behnken Design 2019; pp. 8509-20.
[71]
Lohan SB, Bauersachs S, Ahlberg S, et al. Ultra-small lipid nanoparticles promote the penetration of coenzyme Q10 in skin cells and counteract oxidative stress. Eur J Pharm Biopharm 2015; 89: 201-7.
[http://dx.doi.org/10.1016/j.ejpb.2014.12.008] [PMID: 25500282]
[72]
Chen S, Liu W, Wan J, et al. Preparation of Coenzyme Q10 nanostructured lipid carriers for epidermal targeting with high-pressure microfluidics technique. Drug Dev Ind Pharm 2013; 39(1): 20-8.
[http://dx.doi.org/10.3109/03639045.2011.650648] [PMID: 23116283]
[73]
Fenita S, Tristiana E, Widji S. Coenzyme Q10 nanostructured lipid carriers as an inducer of the skin fibroblast cell and its irritability test in a mice model. J Basic Clin Physiol Pharmacol 2019; 30(6)
[74]
Ahmadi N, Rostamizadeh K, Modarresi-Alam AR. Therapeutic anti-inflammatory potential of different formulations based on coenzyme Q10-loaded nanostructured lipid carrier: In vitro, ex vivo, and in vivo evaluations. Eur J Lipid Sci Technol 2018; 120: 1800232.
[http://dx.doi.org/10.1002/ejlt.201800232]
[75]
Kumar P, Singh A. Nanostructured Lipid Carriers (NLCS): A prominent topical delivery system for conzyme Q10 and Myrica esculenta leaves extract for anti-aging potential. Int J Pharm Pharm Sci 2018; 10(8): 106-12.
[http://dx.doi.org/10.22159/ijpps.2018v10i8.27745]
[76]
Chaiyana W, Anuchapreeda S, Somwongin S, et al. Dermal delivery enhancement of natural anti-ageing compounds from Ocimum sanctum linn. extract by nanostructured lipid carriers. Pharmaceutics 2020; 12(4): 309.
[http://dx.doi.org/10.3390/pharmaceutics12040309] [PMID: 32235376]
[77]
Miao L, Daozhou L, Ying C, Qibing M, Siyuan Z. A resveratrol-loaded nanostructured lipid carrier hydrogel to enhance the anti-UV irradiation and anti-oxidant efficacy. Colloids Surf B Biointerfaces 2021; 204: 111786.
[http://dx.doi.org/10.1016/j.colsurfb.2021.111786] [PMID: 33984613]
[78]
Suter F, Schmid D, Wandrey F, Zülli F, et al. Heptapeptide-loaded solid lipid nanoparticles for cosmetic anti-aging applications. Eur J Pharm Biopharm 2016; 108: 304-9.
[http://dx.doi.org/10.1016/j.ejpb.2016.06.014] [PMID: 27343822]
[79]
Ijaz M, Akhtar N. Fatty acids based α-tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects. J Cosmet Dermatol 2020; 19(11): 3067-76.
[http://dx.doi.org/10.1111/jocd.13346] [PMID: 32129554]
[80]
Maia CS, Mehnert W, Schäfer-Korting M. Solid lipid nanoparticles as drug carriers for topical glucocorticoids. Int J Pharm 2000; 196(2): 165-7.
[http://dx.doi.org/10.1016/S0378-5173(99)00413-5] [PMID: 10699710]
[81]
Madan J, Dua K, Khude PA. Development and evaluation of solid lipid nanoparticles of mometasone furoate for topical delivery. Int J Pharm Investig 2014; 4(2): 60-4.
[http://dx.doi.org/10.4103/2230-973X.133047] [PMID: 25006550]
[82]
Kong X, Zhao Y, Quan P, Fang L. Development of a topical ointment of betamethasone dipropionate loaded nanostructured lipid carrier. Asian J Pharmaceut Sci 2016; 11(2): 248-54.
[http://dx.doi.org/10.1016/j.ajps.2015.07.005]
[83]
Desoqi MH, El-Sawy HS, Kafagy E, Ghorab M, Gad S. Fluticasone propionate-loaded solid lipid nanoparticles with augmented anti-inflammatory activity: Optimisation, characterisation and pharmacodynamic evaluation on rats. J Microencapsul 2021; 38(3): 177-91.
[http://dx.doi.org/10.1080/02652048.2021.1887383] [PMID: 33583315]
[84]
Carvajal-Vidal P, González-Pizarro R, Araya C, et al. Nanostructured lipid carriers loaded with Halobetasol propionate for topical treatment of inflammation: Development, characterization, biopharmaceutical behavior and therapeutic efficacy of gel dosage forms. Int J Pharm 2020; 585: 119480.
[http://dx.doi.org/10.1016/j.ijpharm.2020.119480] [PMID: 32479897]
[85]
Park JH, Bienenfeld A, Orlow SJ, Nagler AR. The use of hormonal antiandrogen therapy in female patients with acne: A 10-year retrospective study. Am J Clin Dermatol 2018; 19(3): 449-55.
[http://dx.doi.org/10.1007/s40257-018-0349-6] [PMID: 29556985]
[86]
Gruber DM, Sator MO, Joura EA, Kokoschka EM, Heinze G, Huber JC. Topical cyproterone acetate treatment in women with acne: A placebo-controlled trial. Arch Dermatol 1998; 134(4): 459-63.
[http://dx.doi.org/10.1001/archderm.134.4.459] [PMID: 9554298]
[87]
İraji F, Momeni A, Naji SM, Siadat AH. The efficacy of topical cyproterone acetate alcohol lotion versus placebo in the treatment of the mild to moderate acne vulgaris: A double blind study. Dermatol Online J 2006; 12(3): 26.
[http://dx.doi.org/10.5070/D34ZJ6N2W3] [PMID: 16638440]
[88]
Štecová J, Mehnert W, Blaschke T, et al. Cyproterone acetate loading to lipid nanoparticles for topical acne treatment: Particle characterisation and skin uptake. Pharm Res 2007; 24(5): 991-1000.
[http://dx.doi.org/10.1007/s11095-006-9225-9] [PMID: 17372681]
[89]
Ghasemiyeh P, Azadi A, Daneshamouz S, Heidari R, Azarpira N, Mohammadi-Samani S. Cyproterone acetate-loaded nanostructured lipid carriers: Effect of particle size on skin penetration and follicular targeting. Pharm Dev Technol 2019; 24(7): 812-23.
[http://dx.doi.org/10.1080/10837450.2019.1596133] [PMID: 30889371]
[90]
Hamishehkar H, Ghanbarzadeh S, Sepehran S, Javadzadeh Y, Adib ZM, Kouhsoltani M. Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: Potential tool for the treatment of androgenic alopecia. Drug Dev Ind Pharm 2016; 42(6): 846-53.
[http://dx.doi.org/10.3109/03639045.2015.1062896] [PMID: 26154267]
[91]
Wang W, Chen L, Huang X, Shao A. Preparation and characterization of minoxidil loaded nanostructured lipid carriers. AAPS PharmSciTech 2017; 18(2): 509-16.
[http://dx.doi.org/10.1208/s12249-016-0519-x] [PMID: 27120090]
[92]
Shah K, Date A, Joshi M, Patravale V. Solid lipid nanoparticles (SLN) of tretinoin: Potential in topical delivery. Int J Pharm 2007; 345(1-2): 163-71.
[http://dx.doi.org/10.1016/j.ijpharm.2007.05.061] [PMID: 17644288]
[93]
Queille-Roussel C, Poncet M, Mesaros S, Clucas A, Baker M, Soloff AM. Comparison of the cumulative irritation potential of adapalene gel and cream with that of erythromycin/tretinoin solution and gel and erythromycin/isotretinoin gel. Clin Ther 2001; 23(2): 205-12.
[http://dx.doi.org/10.1016/S0149-2918(01)80003-5] [PMID: 11293554]
[94]
Gupta S, Wairkar S, Bhatt LK. Isotretinoin and α-tocopherol acetate-loaded solid lipid nanoparticle topical gel for the treatment of acne. J Microencapsul 2020; 37(8): 557-65.
[http://dx.doi.org/10.1080/02652048.2020.1823499] [PMID: 32924680]
[95]
Jain A, Garg NK, Jain A, et al. A synergistic approach of adapalene-loaded nanostructured lipid carriers, and vitamin C co-administration for treating acne. Drug Dev Ind Pharm 2016; 42(6): 897-905.
[http://dx.doi.org/10.3109/03639045.2015.1104343] [PMID: 26577703]
[96]
de Souza Guedes L, Martinez RM, Bou-Chacra NA, Velasco MVR, Rosado C, Baby AR. An overview on topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles. Antioxidants 2021; 10(7): 1034.
[http://dx.doi.org/10.3390/antiox10071034] [PMID: 34206935]
[97]
Maretti E, Leo E, Rustichelli C, Truzzi E, Siligardi C, Iannuccelli V. In vivo β-carotene skin permeation modulated by Nanostructured Lipid Carriers. Int J Pharm 2021; 597: 120322.
[http://dx.doi.org/10.1016/j.ijpharm.2021.120322] [PMID: 33549810]
[98]
Saez V, Souza IDL, Mansur CRE. Lipid nanoparticles (SLN & NLC) for delivery of vitamin E: A comprehensive review. Int J Cosmet Sci 2018; 40(2): 103-16.
[http://dx.doi.org/10.1111/ics.12452] [PMID: 29505675]
[99]
Chen J, Wei N, Lopez-Garcia M, et al. Development and evaluation of resveratrol, Vitamin E, and epigallocatechin gallate loaded lipid nanoparticles for skin care applications. Eur J Pharm Biopharm 2017; 117: 286-91.
[http://dx.doi.org/10.1016/j.ejpb.2017.04.008] [PMID: 28411056]
[100]
Vaz S, Silva R, Amaral MH, Martins E, Sousa Lobo JM, Silva AC. Evaluation of the biocompatibility and skin hydration potential of vitamin E-loaded lipid nanosystems formulations: In vitro and human in vivo studies. Colloids Surf B Biointerfaces 2019; 179: 242-9.
[http://dx.doi.org/10.1016/j.colsurfb.2019.03.036] [PMID: 30974262]
[101]
Montenegro L, Messina C, Manuguerra S, et al. In vitro antioxidant activity and in vivo topical efficacy of lipid nanoparticles co-loading idebenone and tocopheryl acetate. Appl Sci 2019; 9(5): 845.
[http://dx.doi.org/10.3390/app9050845]
[102]
Mascarenhas-Melo F, Carvalho A, Gonçalves MBS, Paiva-Santos AC, Veiga F. Nanocarriers for the topical treatment of psoriasis - pathophysiology, conventional treatments, nanotechnology, regulatory and toxicology. Eur J Pharm Biopharm 2022; 176: 95-107.
[http://dx.doi.org/10.1016/j.ejpb.2022.05.012] [PMID: 35605927]
[103]
Carrascosa JM, Plana A, Ferrándiz C. Effectiveness and safety of psoralen-UVA (PUVA) topical therapy in palmoplantar psoriasis: A report on 48 patients. Actas Dermosifiliogr 2013; 104(5): 418-25.
[104]
Fang JY, Fang CL, Liu CH, Su YH. Lipid nanoparticles as vehicles for topical psoralen delivery: Solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC). Eur J Pharm Biopharm 2008; 70(2): 633-40.
[http://dx.doi.org/10.1016/j.ejpb.2008.05.008]
[105]
Pitzanti G, Rosa A, Nieddu M, et al. Transcutol® p containing slns for improving 8-methoxypsoralen skin delivery. Pharmaceutics 2020; 12(10): 973.
[http://dx.doi.org/10.3390/pharmaceutics12100973] [PMID: 33076355]
[106]
Faiyazuddin M, Akhtar N, Akhter J, et al. Production, characterization, in vitro and ex vivo studies of babchi oil-encapsulated nanostructured solid lipid carriers produced by a hot aqueous titration method. Pharmazie 2010; 65(5): 348-55.
[PMID: 20503927]
[107]
Shaaban M, Nasr M, Tawfik AA, Fadel M, Sammour O. Bergamot oil as an integral component of nanostructured lipid carriers and a photosensitizer for photodynamic treatment of vitiligo: Characterization and clinical experimentation. Expert Opin Drug Deliv 2021; 18(1): 139-50.
[http://dx.doi.org/10.1080/17425247.2021.1844180] [PMID: 33119413]
[108]
Ghani SMA, Roslan NZI, Muda R, Abdul-Aziz A. Encapsulation of Ficus deltoidea extract in nanostructured lipid carrier for anti-melanogenic activity. Bionanoscience 2021; 11(1): 8-20.
[http://dx.doi.org/10.1007/s12668-020-00786-2]
[109]
Krambeck K, Santos D, Otero-Espinar F, Sousa Lobo JM, Amaral MH. Lipid nanocarriers containing Passiflora edulis seeds oil intended for skin application. Colloids Surf B Biointerfaces 2020; 193: 111057.
[http://dx.doi.org/10.1016/j.colsurfb.2020.111057] [PMID: 32388391]
[110]
Dzulhi S, Anwar E, Nurhayati T. Formulation, characterization and in vitro skin penetration of green tea (Camellia sinensis L.) leaves extract-loaded solid lipid nanoparticles. J Appl Pharm Sci 2018; 8: 057-62.
[http://dx.doi.org/10.7324/JAPS.2018.8809]
[111]
Plyduang T, Atipairin A, Sae Yoon A, Sermkaew N, Sakdiset P, Sawatdee S. Formula development of red palm (Elaeis guineensis) fruit extract loaded with solid lipid nanoparticles containing creams and its anti-aging efficacy in healthy volunteers. Cosmetics 2021; 9(1): 3.
[http://dx.doi.org/10.3390/cosmetics9010003]
[112]
Battaglia L, Ugazio E. Lipid nano- and microparticles: An overview of patent-related research. J Nanomater 2019; 2019: 22.
[113]
Jain P, Rahi P, Pandey V, Asati S, Soni V. Nanostructure lipid carriers: A modish contrivance to overcome the ultraviolet effects. Egyptian J Basic App Sci 2017; 4(2): 89-100.
[http://dx.doi.org/10.1016/j.ejbas.2017.02.001]
[114]
Clinical assessment of oxiconazole nitrate solid lipid nanoparticles loaded gel. NCT03823040, 2019.
[115]
Agrawal Y, Petkar KC, Sawant KK. Development, evaluation and clinical studies of Acitretin loaded nanostructured lipid carriers for topical treatment of psoriasis. Int J Pharm 2010; 401(1-2): 93-102.
[http://dx.doi.org/10.1016/j.ijpharm.2010.09.007] [PMID: 20858539]
[116]
Ferraris C, Rimicci C, Garelli S, Ugazio E, Battaglia L. Nanosystems in cosmetic products: A brief overview of functional, market, regulatory and safety concerns. Pharmaceutics 2021; 13(9): 1408.
[http://dx.doi.org/10.3390/pharmaceutics13091408] [PMID: 34575484]
[117]
de Vringer T. Topical preparation containing a suspension of solid lipid particles. EP Patent 0786251A2, 1997.
[118]
Kaul S, Gulati N, Verma D, Mukherjee S, Nagaich U. Role of nanotechnology in cosmeceuticals: A review of recent advances. J Pharm 2018; 2018: 1-19.
[http://dx.doi.org/10.1155/2018/3420204] [PMID: 29785318]
[119]
Müller R, Petersen R, Hommoss A, Pardeike J. Nanostructured lipid carriers (NLC) in cosmetic dermal products. Adv Drug Deliv Rev 2007; 59(6): 522-30.
[http://dx.doi.org/10.1016/j.addr.2007.04.012] [PMID: 17602783]
[120]
Souto EB, Jäger E, Jäger A, et al. Lipid nanomaterials for targeted delivery of dermocosmetic ingredients: Advances in photoprotection and skin anti-aging. Nanomaterials 2022; 12(3): 377.
[http://dx.doi.org/10.3390/nano12030377] [PMID: 35159721]
[121]
Ahmad J. Lipid nanoparticles based cosmetics with potential application in alleviating skin disorders. Cosmetics 2021; 8(3): 84.
[http://dx.doi.org/10.3390/cosmetics8030084]
[122]
Gupta V, Mohapatra S, Mishra H, et al. Nanotechnology in cosmetics and cosmeceuticals-a review of latest advancements. Gels 2022; 8(3): 173.
[http://dx.doi.org/10.3390/gels8030173] [PMID: 35323286]
[123]
SCCS (Scientific Committee on Consumer Safety). Guidance on the Safety Assessment of Nanomaterials in Cosmetics, 30-31 October 2019, SCCS/1611/19. 2019. Available from: https://health.ec.europa.eu/system/files/2020-10/sccs_o_233_0.pdf

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