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Current Nanomaterials

Editor-in-Chief

ISSN (Print): 2405-4615
ISSN (Online): 2405-4623

Review Article

Overcoming the Therapeutic Limitation of Ocular Drug Delivery with the Help of Novel Drug Carriers

Author(s): Sumbul Shadab, Md. Aftab Alam*, Pramod Kumar Sharma and Deepika Paliwal

Volume 10, Issue 1, 2025

Published on: 10 October, 2023

Page: [33 - 41] Pages: 9

DOI: 10.2174/2405461508666230801095201

Price: $65

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Abstract

One of the difficult areas of pharmaceutical research is the controlled delivery of drugs to the eye. The drainage of the solution, the quick turnover of the tears, and the diluting effects of lacrimation all contribute to a short drug contact time and poor ocular bioavailability with conventional systems. Drug delivery system design is also governed by the eye's anatomical barriers and its physiological conditions. To prevent retinal uptake of drugs given systemically, the blood-retinal barrier (BRB) has tight junctions that block drug entry. It has been discovered that conventional ophthalmic dosage forms can be avoided along with the problems they cause by using nanocarriers. There are a variety of nanosized carriers available for this purpose, including liposomes, niosomes, polymeric micelles, Nanocarrier-loaded gels, Solid Lipid Nanoparticles (SLNs), polymeric nanoparticles, and dendrimers. This review gives a resume of the different parts of ocular delivery, with a focus on nanocarrier- based strategies, such as delivery routes and the challenges and limits of making new nanocarriers.

Keywords: Ocular drug delivery, nanoparticle, administration of drugs, liposome, niosomes, dendrimer.


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