Title:Marine Bioactive Phytoconstituents in Autoimmune Disorders: Role and
Mechanism - A Review
Volume: 22
Issue: 1
Author(s): Dhanalekshmi Unnikrishnan Meenakshi, Gurpreet Kaur Narde, Sameera Siddiqui and Alka Ahuja*
Affiliation:
- College of Pharmacy, National University of Science and Technology, Muscat, Sultanate of Oman
Keywords:
Autoimmune disorders, phytoconstituents, marine, immunomodulatory, anti-inflammatory, metabolites, flora, fauna.
Abstract: The significance of Autoimmune Disorders (Ads) is underscored by their chronic
nature, high maintenance costs, and complexity affecting numerous organs and tissues. A
more comprehensive approach to treating Ads is required across patient populations. A revolutionary
area for obtaining an integrated therapeutic option is natural phytoconstituents. Diverse
biomolecules with promising properties can be found in abundance in the marine environment.
Many substances have been identified from sponges, bacteria, fungi, cyanobacteria,
and algae that have been shown to have immunomodulatory activities and may be used as
possible treatments for Ads. Marine-derived bioactive substances have been demonstrated to
affect immunological responses and to be essential in immunotherapies. The amount of information
about the specific effects of substances obtained from marine sources utilized as dietary
supplements or for treating immune-related diseases is growing. This paper discusses
many sources of potential marine metabolic chemicals, such as maritime flora and fauna. Numerous
marine phytoconstituents have recently been isolated, described, and identified, and
they are currently undergoing human usage studies. We have attempted to consolidate information
concerning phytoconstituents from marine sources with anti-inflammatory and immunomodulatory
properties in this review, and we have briefly explored their methods of action.
In order to provide a baseline of knowledge for promoting marine flora-based phytoconstituents
in the current context of increasing Ads incidence, deprived of the more affordable,
safe, and effective medications to combat the terrible human disease, this paper reviews the
works thus far conducted on this aspect.