Iron Deficiency Anemia: An Updated Review

Alexander   K.C.   Leung; Joseph   M.   Lam; Alex   H.C.   Wong; Kam Lun      Hon; Xiuling      Li
doi:10.2174/1573396320666230727102042
Abstract

Background: Worldwide, iron deficiency anemia is the most prevalent nutritional deficiency disorder and the leading cause of anemia in children, especially in developing countries. When present in early childhood, especially if severe and prolonged, iron deficiency anemia can result in neurodevelopmental and cognitive deficits, which may not always be fully reversible even following the correction of iron deficiency anemia.
Objective: This article aimed to familiarize physicians with the clinical manifestations, diagnosis, evaluation, prevention, and management of children with iron deficiency anemia.
Methods: A PubMed search was conducted in February 2023 in Clinical Queries using the key term "iron deficiency anemia". The search strategy included all clinical trials (including open trials, non-randomized controlled trials, and randomized controlled trials), observational studies (including case reports and case series), and reviews (including narrative reviews, clinical guidelines, and meta-analyses) published within the past 10 years. Google, UpToDate, and Wikipedia were also searched to enrich the review. Only papers published in the English literature were included in this review. The information retrieved from the search was used in the compilation of the present article.
Results: Iron deficiency anemia is most common among children aged nine months to three years and during adolescence. Iron deficiency anemia can result from increased demand for iron, inadequate iron intake, decreased iron absorption (malabsorption), increased blood loss, and rarely, defective plasma iron transport. Most children with mild iron deficiency anemia are asymptomatic. Pallor is the most frequent presenting feature. In mild to moderate iron deficiency anemia, poor appetite, fatigability, lassitude, lethargy, exercise intolerance, irritability, and dizziness may be seen. In severe iron deficiency anemia, tachycardia, shortness of breath, diaphoresis, and poor capillary refilling may occur. When present in early childhood, especially if severe and prolonged, iron deficiency anemia can result in neurodevelopmental and cognitive deficits, which may not always be fully reversible even with the correction of iron deficiency anemia. A low hemoglobin and a peripheral blood film showing hypochromia, microcytosis, and marked anisocytosis, should arouse suspicion of iron deficiency anemia. A low serum ferritin level may confirm the diagnosis. Oral iron therapy is the first-line treatment for iron deficiency anemia. This can be achieved by oral administration of one of the ferrous preparations, which is the most cost-effective medication for the treatment of iron deficiency anemia. The optimal response can be achieved with a dosage of 3 to 6 mg/kg of elemental iron per day. Parenteral iron therapy or red blood cell transfusion is usually not necessary.
Conclusion: In spite of a decline in prevalence, iron deficiency anemia remains a common cause of anemia in young children and adolescents, especially in developing countries; hence, its prevention is important. Primary prevention can be achieved by supplementary iron or iron fortification of staple foods. The importance of dietary counseling and nutritional education cannot be overemphasized. Secondary prevention involves screening for, diagnosing, and treating iron deficiency anemia. The American Academy of Pediatrics recommends universal laboratory screening for iron deficiency anemia at approximately one year of age for healthy children. Assessment of risk factors associated with iron deficiency anemia should be performed at this time. Selective laboratory screening should be performed at any age when risk factors for iron deficiency anemia have been identified.
Keywords: Cognitive deficits, serum ferritin, heme, hemoglobin, neurodevelopmental deficit, pallor.
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Graphical Abstract

[1]
Khare A, Samudre S, Arora A. Sneak-peek into iron deficiency anemia in India: The need for food-based interventions and enhancing iron bioavailability. Food Res Int  2022; 162(A): 111927.
 [http://dx.doi.org/10.1016/j.foodres.2022.111927]

[2]
Mast AE, Blinder MA, Dietzen DJ. Reticulocyte hemoglobin content. Am J Hematol  2008; 83(4): 307-10.
 [http://dx.doi.org/10.1002/ajh.21090] [PMID:  18027835]

[3]
Nwaba A, Su M, Rajamanickam V, et al. Community preventive health education intervention for pediatric irondeficiency anemia in Rural Southeast Nigeria. Ann Glob Health  2022; 88(1): 105.
 [http://dx.doi.org/10.5334/aogh.3625] [PMID:  36474896]

[4]
Park YJ, Lim HS, Kim TH. Annual prevalence, health expenditures, and co-morbidities trend of iron deficiency anemia in Korea: National health insurance service data from 2002 to 2013. Int J Environ Res Public Health  2020; 17(12): 4433.
 [http://dx.doi.org/10.3390/ijerph17124433] [PMID:  32575693]

[5]
De Falco L, Silvestri L, Kannengiesser C, et al. Functional and clinical impact of novel TMPRSS6 variants in ironrefractory iron-deficiency anemia patients and genotype-phenotype studies  Hum Mutat  2014; 35(11) : n/a.
 [http://dx.doi.org/10.1002/humu.22632] [PMID: 25156943]

[6]
Lozoff B, Jimenez E, Wolf AW. Long-term developmental outcome of infants with iron deficiency. N Engl J Med  1991; 325(10): 687-94.
 [http://dx.doi.org/10.1056/NEJM199109053251004] [PMID:  1870641]

[7]
Desforges JF, Oski FA. Iron deficiency in infancy and childhood. N Engl J Med  1993; 329(3): 190-3.
 [http://dx.doi.org/10.1056/NEJM199307153290308] [PMID:  8515791]

[8]
Looker AC, Dallman PR, Carroll MD, Gunter EW, Johnson CL. Prevalence of iron deficiency in the United States. JAMA  1997; 277(12): 973-6.
 [http://dx.doi.org/10.1001/jama.1997.03540360041028] [PMID:  9091669]

[9]
Baker RD, Greer FR. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age). Pediatrics  2010; 126(5): 1040-50.
 [http://dx.doi.org/10.1542/peds.2010-2576] [PMID:  20923825]

[10]
Cappellini MD, Comin-Colet J, de Francisco A, et al. Iron deficiency across chronic inflammatory conditions: International expert opinion on definition, diagnosis, and management. Am J Hematol  2017; 92(10): 1068-78.
 [http://dx.doi.org/10.1002/ajh.24820] [PMID:  28612425]

[11]
Powers JM. Iron deficiency in infants and children <12 years: Screening, prevention, clinical manifestations, and diagnosis.In: Post, TW, ed UpToDate Waltham, MA (Accessed on March 20, 2023). 

[12]
Taylor S, Rampton D. Treatment of iron deficiency anemia: practical considerations. Polish Archives of Internal Medicine  2015; 125(6): 452-60.
 [http://dx.doi.org/10.20452/pamw.2888] [PMID:  25922941]

[13]
Leung AK, Chan KW. Iron deficiency anemia. Adv Pediatr  2001; 48: 385-408.
 [PMID:  11480764]

[14]
Subramaniam G, Girish M. Iron deficiency anemia in children. Indian J Pediatr  2015; 82(6): 558-64.
 [http://dx.doi.org/10.1007/s12098-014-1643-9] [PMID:  25636824]

[15]
Provan D. Mechanisms and management of iron deficiency anaemia. Br J Haematol  1999; 105 (Suppl. 1): 19-26.
 [PMID:  10330929]

[16]
Kaplan J, Ward DM, De Domenico I. The molecular basis of iron overload disorders and iron-linked anemias. Int J Hematol  2011; 93(1): 14-20.
 [http://dx.doi.org/10.1007/s12185-010-0760-0] [PMID:  21210258]

[17]
Camaschella C. Iron-Deficiency Anemia. N Engl J Med  2015; 372(19): 1832-43.
 [http://dx.doi.org/10.1056/NEJMra1401038] [PMID:  25946282]

[18]
El Gendy FM. EL-Hawy MA, Shehata AMF, Osheba HE. Erythroferrone and iron status parameters levels in pediatric patients with iron deficiency anemia. Eur J Haematol  2018; 100(4): 356-60.
 [http://dx.doi.org/10.1111/ejh.13021] [PMID:  29282766]

[19]
Frewin R, Henson A, Provan D. ABC of Clinical haematology: Iron deficiency anaemia. BMJ  1997; 314(7077): 360-3.
 [http://dx.doi.org/10.1136/bmj.314.7077.360] [PMID:  9040336]

[20]
Centers for Disease Control and Prevention. Recommendations to prevent and control iron deficiency in the United States. MMWR Recomm Rep  1998; 47(RR-3): 1-29.
 [PMID:  9563847]

[21]
Sharp P, Srai SK. Molecular mechanisms involved in intestinal iron absorption. World J Gastroenterol  2007; 13(35): 4716-24.
 [http://dx.doi.org/10.3748/wjg.v13.i35.4716] [PMID:  17729393]

[22]
Hallberg L. Bioavailability of dietary iron in man. Annu Rev Nutr  1981; 1(1): 123-47.
 [http://dx.doi.org/10.1146/annurev.nu.01.070181.001011] [PMID:  6764713]

[23]
Bothwell TH. Overview and mechanisms of iron regulation. Nutr Rev  1995; 53(9): 237-45.
 [http://dx.doi.org/10.1111/j.1753-4887.1995.tb05480.x] [PMID:  8577406]

[24]
Committee on Nutrition, American Academy of Pediatrics. In: Pediatric Nutrition Handbook 8th edition Elk Village, ILL: American Academy of Pediatrics.   2019; pp. 561-90.

[25]
Clark SF. Iron deficiency anemia. Nutr Clin Pract  2008; 23(2): 128-41.
 [http://dx.doi.org/10.1177/0884533608314536] [PMID:  18390780]

[26]
Kwiatkowski JL, West TB, Heidary N, Smith-Whitley K, Cohen AR. Severe iron deficiency anemia in young children. J Pediatr  1999; 135(4): 514-6.
 [http://dx.doi.org/10.1016/S0022-3476(99)70177-0] [PMID:  10518088]

[27]
Paoletti G, Bogen DL, Ritchey AK. Severe iron-deficiency anemia still an issue in toddlers. Clin Pediatr (Phila)  2014; 53(14): 1352-8.
 [http://dx.doi.org/10.1177/0009922814540990] [PMID:  24990367]

[28]
De Andrade Cairo RC, Rodrigues Silva L, Carneiro Bustani N, Ferreira Marques CD. Iron deficiency anemia in adolescents; a literature review. Nutr Hosp  2014; 29(6): 1240-9.
 [http://dx.doi.org/10.3305/nh.2014.29.6.7245] [PMID:  24972460]

[29]
Araújo LKAR, Faria JCP, Sarni ROS. Iron deficiency anemia in infants in Sousa (PB), Brazil: an association with nutritional status. Rev Assoc Med Bras 2022.

[30]
Aydın B, Özçelik S, Kilit TP, Eraslan S, Çelik M, Onbaşı K. Relationship between glycosylated hemoglobin and iron deficiency anemia: A common but overlooked problem. Prim Care Diabetes  2022; 16(2): 312-7.
 [http://dx.doi.org/10.1016/j.pcd.2022.01.002] [PMID:  35000894]

[31]
Elalfy MS, Hamdy AM, Abdel Maksoud SS, Abdel Megeed RI. Pattern of milk feeding and family size as risk factors for iron deficiency anemia among poor Egyptian infants 6 to 24 months old. Nutr Res  2012; 32(2): 93-9.
 [http://dx.doi.org/10.1016/j.nutres.2011.12.017] [PMID:  22348457]

[32]
Farkhondeh T, Mansouri B, Binkowski LJ, et al. Blood lead concentrations in children with iron deficiency anemia: a systematic review and meta-analysis. Environ Sci Pollut Res Int  2022; 29(3): 3199-212.
 [http://dx.doi.org/10.1007/s11356-021-17301-z] [PMID:  34731423]

[33]
Muleviciene A, Sestel N, Stankeviciene S, et al. Assessment of risk factors for iron deficiency anemia in infants and young children: A case-control study. Breastfeed Med  2018; 13(7): 493-9.
 [http://dx.doi.org/10.1089/bfm.2018.0083] [PMID:  30095285]

[34]
Powers JM, Buchanan GR. Potential for improved screening, diagnosis, and treatment for iron deficiency and iron deficiency anemia in young children. J Pediatr  2017; 188: 8-10.
 [http://dx.doi.org/10.1016/j.jpeds.2017.04.069] [PMID:  28549635]

[35]
Powers JM, Buchanan GR, Adix L, Zhang S, Gao A, McCavit TL. Effect of low-dose ferrous sulfate vs iron polysaccharide complex on hemoglobin concentration in young children with nutritional iron-deficiency anemia: A randomized clinical trial. JAMA  2017; 317(22): 2297-304.
 [http://dx.doi.org/10.1001/jama.2017.6846] [PMID:  28609534]

[36]
Pradeepa R, Shreya L, Anjana RM, et al. Frequency of iron deficiency anemia in type 2 diabetes - Insights from tertiary diabetes care cen-tres across India. Diabetes Metab Syndr  2022; 16(11): 102632.
 [http://dx.doi.org/10.1016/j.dsx.2022.102632] [PMID:  36343394]

[37]
Rocha ÉMB, Lopes AF, Pereira SM, et al. Iron deficiency anemia and its relationship with socioeconomic vulnerability. Rev Paul Pediatr  2020; 38: e2019031.
 [http://dx.doi.org/10.1590/1984-0462/2020/38/2019031] [PMID:  32520297]

[38]
Siu AL. Screening for iron deficiency anemia in young children: USPSTF Recommendation Statement. Pediatrics  2015; 136(4): 746-52.
 [http://dx.doi.org/10.1542/peds.2015-2567] [PMID:  26347426]

[39]
Tantracheewathorn S, Lohajaroensub S. Incidence and risk factors of iron deficiency anemia in term infants. J Med Assoc Thai  2005; 88(1): 45-51.
 [PMID:  15960216]

[40]
Andelman MB, Sered BR. Utilization of dietary iron by term infants. A study of 1,048 infants from a low socioeconomic population. Am J Dis Child  1966; 111(1): 45-55.
 [http://dx.doi.org/10.1001/archpedi.1966.02090040081007] [PMID:  5900284]

[41]
Lanzkowsky P. Problems in diagnosis of iron deficiency anemia  Pediatr Ann  1985; 14(9): 618-6636. 622-623, 627 passim.
 [http://dx.doi.org/10.3928/0090-4481-19850901-07] [PMID: 3903633]

[42]
Miller JL. Iron deficiency anemia: a common and curable disease. Cold Spring Harb Perspect Med  2013; 3(7): a011866.
 [http://dx.doi.org/10.1101/cshperspect.a011866] [PMID:  23613366]

[43]
Yip R, Walsh KM, Goldfarb MG, Binkin NJ. Declining prevalence of anemia in childhood in a middle-class setting: a pediatric success story? Pediatrics  1987; 80(3): 330-4.
 [http://dx.doi.org/10.1542/peds.80.3.330] [PMID:  3627882]

[44]
Gupta P, Perrine C, Mei Z, Scanlon K. Iron, anemia, and iron deficiency anemia among young children in the United States. Nutrients  2016; 8(6): 330.
 [http://dx.doi.org/10.3390/nu8060330] [PMID:  27249004]

[45]
Brotanek JM, Halterman JS, Auinger P, Flores G, Weitzman M. Iron deficiency, prolonged bottle-feeding, and racial/ethnic disparities in young children. Arch Pediatr Adolesc Med  2005; 159(11): 1038-42.
 [http://dx.doi.org/10.1001/archpedi.159.11.1038] [PMID:  16275794]

[46]
Kumar SB, Arnipalli SR, Mehta P, Carrau S, Ziouzenkova O. Iron deficiency anemia: Efficacy and limitations of nutritional and comprehensive mitigation strategies. Nutrients  2022; 14(14): 2976.
 [http://dx.doi.org/10.3390/nu14142976] [PMID:  35889932]

[47]
Igbinosa I, Berube C, Lyell DJ. Iron deficiency anemia in pregnancy. Curr Opin Obstet Gynecol  2022; Publish Ahead of Print(2): 69-76.
 [http://dx.doi.org/10.1097/GCO.0000000000000772] [PMID: 35230991]

[48]
James AH. Iron deficiency anemia in pregnancy. Obstet Gynecol  2021; 138(4): 663-74.
 [http://dx.doi.org/10.1097/AOG.0000000000004559] [PMID:  34623079]

[49]
Miller V, Swaney S, Deinard A. Impact of the WIC program on the iron status of infants. Pediatrics  1985; 75(1): 100-5.
 [http://dx.doi.org/10.1542/peds.75.1.100] [PMID:  3966032]

[50]
Brady PG. Iron deficiency anemia: a call for aggressive diagnostic evaluation. South Med J  2007; 100(10): 966-7.
 [http://dx.doi.org/10.1097/SMJ.0b013e3181520699] [PMID:  17943034]

[51]
Marques RF, Taddei JA, Lopez FA, Braga JA. Breastfeeding exclusively and iron deficiency anemia during the first 6 months of age. Rev Assoc Med Bras 2014.

[52]
Pisacane A, De Vizia B, Valiante A, et al. Iron status in breast-fed infants. J Pediatr  1995; 127(3): 429-31.
 [http://dx.doi.org/10.1016/S0022-3476(95)70076-5] [PMID:  7658275]

[53]
Tsai SF, Chen SJ, Yen HJ, et al. Iron deficiency anemia in predominantly breastfed young children. Pediatr Neonatol  2014; 55(6): 466-9.
 [http://dx.doi.org/10.1016/j.pedneo.2014.02.005] [PMID:  24953965]

[54]
Mantadakis E, Zikidou P, Tsouvala E, Thomaidis S, Chatzimichael A. Severe iron deficiency anemia and anasarca edema due to excessive cow’s milk intake. Turk J Pediatr  2019; 61(1): 102-6.
 [http://dx.doi.org/10.24953/turkjped.2019.01.016] [PMID:  31559729]

[55]
Vehapoglu A, Ozgurhan G, Ustabas Kahraman F, Cakın ZE, Sumbul B. Association between consumption of cow’s milk and iron defi-ciency anemia in children: Are there roles for hepcidin-25/ferroportin? A case-control study. Pediatr Hematol Oncol  2020; 37(8): 676-86.
 [http://dx.doi.org/10.1080/08880018.2020.1782547] [PMID:  32705943]

[56]
Anand BS, Callender ST, Warner GT. Absorption of inorganic and haemoglobin iron in coeliac disease. Br J Haematol  1977; 37(3): 409-14.
 [http://dx.doi.org/10.1111/j.1365-2141.1977.tb01012.x] [PMID:  603771]

[57]
Leung AKC, Leung AAM, Wong AHC, Sergi CM, Kam JKM. Giardiasis: An Overview. Recent Pat Inflamm Allergy Drug Discov  2019; 13(2): 134-43.
 [http://dx.doi.org/10.2174/1872213X13666190618124901] [PMID:  31210116]

[58]
Miguel N, Costa E, Santalha M Jr, et al. Refractory iron-deficiency anemia and autoimmune atrophic gastritis in pediatric age group: analy-sis of 8 clinical cases. J Pediatr Hematol Oncol  2014; 36(2): 134-9.
 [http://dx.doi.org/10.1097/MPH.0000000000000069] [PMID:  24327126]

[59]
Capra AP, Ferro E, Cannavò L, La Rosa MA, Zirilli G. A child with severe iron-deficiency anemia and a complex TMPRSS6 genotype. Hematology  2017; 22(9): 559-64.
 [http://dx.doi.org/10.1080/10245332.2017.1317990] [PMID:  28447549]

[60]
Kodama K, Noguchi A, Adachi H, Hebiguchi M, Yano M, Takahashi T. Novel mutation in the TMPRSS6 gene with ironrefractory iron deficiency anemia. Pediatr Int  2014; 56(4): e41-4.
 [http://dx.doi.org/10.1111/ped.12395] [PMID:  25252070]

[61]
Yaish HM, Farrell CP, Christensen RD, et al. Two novel mutations in TMPRSS6 associated with ironrefractory iron deficiency anemia in a mother and child. Blood Cells Mol Dis  2017; 65: 38-40.
 [http://dx.doi.org/10.1016/j.bcmd.2017.04.002] [PMID:  28460265]

[62]
Finberg KE. Ironrefractory iron deficiency anemia. Semin Hematol  2009; 46(4): 378-86.
 [http://dx.doi.org/10.1053/j.seminhematol.2009.06.006] [PMID:  19786206]

[63]
Sal E, Keskin EY, Yenicesu I, Bruno M, De Falco L. Ironrefractory iron deficiency anemia (IRIDA) cases with 2 novel TMPRSS6 muta-tions. Pediatr Hematol Oncol  2016; 33(3): 226-32.
 [http://dx.doi.org/10.3109/08880018.2016.1157229] [PMID:  27120435]

[64]
Conway M, Marcon P, Meinert P, et al. A toddler with treatmentresistant iron deficiency anemia. Pediatrics  2018; 142(1): e20172971.
 [http://dx.doi.org/10.1542/peds.2017-2971] [PMID:  29950397]

[65]
Lai FP, Yang YJ. The prevalence and characteristics of cow’s milk protein allergy in infants and young children with iron deficiency anemia. Pediatr Neonatol  2018; 59(1): 48-52.
 [http://dx.doi.org/10.1016/j.pedneo.2017.01.004] [PMID:  28698024]

[66]
Leung AK. Food allergy: a clinical approach. Adv Pediatr  1998; 45: 145-77.
 [PMID:  9742301]

[67]
Ziegler EE, Fomon SJ, Nelson SE, et al. Cow milk feeding in infancy: Further observations on blood loss from the gastrointestinal tract. J Pediatr  1990; 116(1): 11-8.
 [http://dx.doi.org/10.1016/S0022-3476(05)90003-6] [PMID:  2295949]

[68]
Fomon SJ, Ziegler EE, Nelson SE, Edwards BB. Cow milk feeding in infancy: Gastrointestinal blood loss and iron nutritional status. J Pediatr  1981; 98(4): 540-5.
 [http://dx.doi.org/10.1016/S0022-3476(81)80756-1] [PMID:  7193717]

[69]
Carvalho FSG, de Medeiros IA, Antunes H. Prevalence of iron deficiency anemia and iron deficiency in a pediatric population with in-flammatory bowel disease. Scand J Gastroenterol  2017; 52(10): 1099-103.
 [http://dx.doi.org/10.1080/00365521.2017.1342137] [PMID:  28643539]

[70]
Danko I, Weidkamp M. Correction of iron deficiency anemia with intravenous iron sucrose in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr  2016; 63(5): e107-11.
 [http://dx.doi.org/10.1097/MPG.0000000000001383] [PMID:  27540710]

[71]
Ertekin V, Tosun MS, Küçük N. The prevalence of celiac disease in children with iron-deficiency anemia. Turk J Gastroenterol  2013; 24(4): 334-8.
 [http://dx.doi.org/10.4318/tjg.2013.0529] [PMID:  24254265]

[72]
Narang M, Natarajan R, Shah D, Puri AS, Manchanda V, Kotru M. Celiac disease in children with moderate-to-severe iron-deficiency anemia. Indian Pediatr  2018; 55(1): 31-4.
 [http://dx.doi.org/10.1007/s13312-018-1223-6] [PMID:  29396932]

[73]
Sanseviero MT, Mazza GA, Pullano MN, et al. Iron deficiency anemia in newly diagnosed celiac disease in children. Minerva Pediatr  2016; 68(1): 1-4.
 [PMID:  26864718]

[74]
Valério de Azevedo S, Maltez C, Lopes AI. Pediatric Crohn’s disease, iron deficiency anemia and intravenous iron treatment: a follow-up study. Scand J Gastroenterol  2017; 52(1): 29-33.
 [http://dx.doi.org/10.1080/00365521.2016.1224381] [PMID:  27576956]

[75]
Olsen A, Magnussen P, Ouma JH, Andreassen J, Friis H. The contribution of hookworm and other parasitic infections to haemoglobin and iron status among children and adults in western Kenya. Trans R Soc Trop Med Hyg  1998; 92(6): 643-9.
 [http://dx.doi.org/10.1016/S0035-9203(98)90795-7] [PMID:  10326110]

[76]
Stoltzfus RJ, Chwaya HM, Tielsch JM, Schulze KJ, Albonico M, Savioli L. Epidemiology of iron deficiency anemia in Zanzibari school-children: the importance of hookworms. Am J Clin Nutr  1997; 65(1): 153-9.
 [http://dx.doi.org/10.1093/ajcn/65.1.153] [PMID:  8988928]

[77]
Barnett K, Emder P, Day AS, Selby WS. Tapeworm infestation: a cause of iron deficiency anemia shown by capsule endoscopy. Gastrointest Endosc  2007; 66(3): 625-7.
 [http://dx.doi.org/10.1016/j.gie.2006.12.004] [PMID:  17521636]

[78]
Leung AKC, Fong JHS, Pinto-Rojas A. Pediculosis Capitis. J Pediatr Health Care  2005; 19(6): 369-73.
 [http://dx.doi.org/10.1016/j.pedhc.2005.07.002] [PMID:  16286223]

[79]
Leung AKC, Leung AAM, Wong AHC, Hon KL. Human ascariasis: An updated review. Recent Pat Inflamm Allergy Drug Discov  2020; 14(2): 133-45.
 [http://dx.doi.org/10.2174/22122710MTA3eOTIl5] [PMID:  32628606]

[80]
Cooke AG, McCavit TL, Buchanan GR, Powers JM. Iron deficiency anemia in adolescents who present with heavy menstrual bleeding. J Pediatr Adolesc Gynecol  2017; 30(2): 247-50.
 [http://dx.doi.org/10.1016/j.jpag.2016.10.010] [PMID:  27789349]

[81]
Trillo A, Kronenfeld R, Simms-Cendan J, Davis JA, Corrales-Medina FF. High prevalence of congenital factor VII (FVII) deficiency in adolescent females with heavy menstrual bleeding and iron deficiency anemia. J Pediatr Adolesc Gynecol  2022; 35(6): 647-52.
 [http://dx.doi.org/10.1016/j.jpag.2022.07.013] [PMID:  35917902]

[82]
Cole SK, Billewicz WZ, Thomson AM. Sources of variation in menstrual blood loss. BJOG  1971; 78(10): 933-9.
 [http://dx.doi.org/10.1111/j.1471-0528.1971.tb00208.x] [PMID:  5111902]

[83]
Kivijärvi A, Timonen H, Rajamäki A, Grönroos M. Iron deficiency in women using modern copper intrauterine devices. Obstet Gynecol  1986; 67(1): 95-8.
 [PMID:  3940345]

[84]
Sankararaman S, Shah K, Maddox K, Velayuthan S, Scott LK. Clinical case of the month. Idiopathic pulmonary hemosiderosis presenting as a rare cause of iron deficiency anemia in a toddler--a diagnostic challenge. J La State Med Soc  2012; 164(5): 293-6.
 [PMID:  23362597]

[85]
Leung AKC, Lam JM, Leong KF, Barankin B, Hon KL. Paediatrics: how to manage pediculosis capitis. Drugs Context  2021; 2022(11)
 [http://dx.doi.org/10.7573/dic.2021-11-3] [PMID:  35371269]

[86]
Leung AKC, Barankin B, Leong KF. Pruritic erythematous papules in a previously well teenager. Paediatr Child Health  2018; 23(2): 119-21.
 [http://dx.doi.org/10.1093/pch/pxx173] [PMID:  29686497]

[87]
Nissenson AR, Strobos JUR. Iron deficiency in patients with renal failure. Kidney Int  1999; 55: S18-21.
 [http://dx.doi.org/10.1046/j.1523-1755.1999.055Suppl.69018.x] [PMID:  10084282]

[88]
Geethanath RM, Ramji S, Thirupuram S, Rao YN. Effect of timing of cord clamping on the iron status of infants at 3 months. Indian Pediatr  1997; 34(2): 103-6.
 [PMID:  9255002]

[89]
Grajeda R, Pérez-Escamilla R, Dewey KG. Delayed clamping of the umbilical cord improves hematologic status of Guatemalan infants at 2 mo of age. Am J Clin Nutr  1997; 65(2): 425-31.
 [http://dx.doi.org/10.1093/ajcn/65.2.425] [PMID:  9022526]

[90]
Goya N, Miyazaki S, Kodate S, Ushio B. A family of congenital atransferrinemia. Blood  1972; 40(2): 239-45.
 [http://dx.doi.org/10.1182/blood.V40.2.239.239] [PMID:  4625559]

[91]
Shamsian BS, Rezaei N, Arzanian MT, Alavi S, Khojasteh O, Eghbali A. Severe hypochromic microcytic anemia in a patient with congenital atransferrinemia. Pediatr Hematol Oncol  2009; 26(5): 356-62.
 [http://dx.doi.org/10.1080/08880010902973251] [PMID:  19579082]

[92]
Beaumont-Epinette MP, Delobel JB, Ropert M, et al. Hereditary hypotransferrinemia can lead to elevated transferrin saturation and, when associated to HFE or HAMP mutations, to iron overload. Blood Cells Mol Dis  2015; 54(2): 151-4.
 [http://dx.doi.org/10.1016/j.bcmd.2014.11.020] [PMID:  25486930]

[93]
Chandra D, Dhingra B, Seth T, et al. Congenital hypotransferrinemia, an unusual cause of iron deficiency anemia: Report of two cases. Indian J Hematol Blood Transfus  2017; 33(3): 402-4.
 [http://dx.doi.org/10.1007/s12288-016-0746-z] [PMID:  28824244]

[94]
Hamill RL, Woods JC, Cook BA. Congenital atransferrinemia. A case report and review of the literature. Am J Clin Pathol  1991; 96(2): 215-8.
 [http://dx.doi.org/10.1093/ajcp/96.2.215] [PMID:  1862777]

[95]
Aslan D. Addition of oral iron to plasma transfusion in human congenital hypotransferrinemia: A 10-year observational follow-up with the effects on hematological parameters and growth. Pediatr Blood Cancer  2018; 65(2): e26789.
 [http://dx.doi.org/10.1002/pbc.26789] [PMID:  28895280]

[96]
Dabboubi R, Amri Y, Yahyaoui S, et al. A new case of congenital atransferrinemia with a novel splice site mutation: c.293-63del. Eur J Med Genet  2020; 63(5): 103874.
 [http://dx.doi.org/10.1016/j.ejmg.2020.103874] [PMID:  32028041]

[97]
Huang SC, Yang YJ, Cheng CN, Chen JS, Lin CH. The etiology and treatment outcome of iron deficiency and iron deficiency anemia in children. J Pediatr Hematol Oncol  2010; 32(4): 282-5.
 [http://dx.doi.org/10.1097/MPH.0b013e3181d69b2b] [PMID:  20404750]

[98]
Mulayamkuzhiyil Saju J, Mandal N, Kham NI, et al. Is Helicobacter pylori a reason for unexplained iron deficiency anemia: A systematic review. Cureus  2022; 14(9): e29112.
 [http://dx.doi.org/10.7759/cureus.29112] [PMID:  36133500]

[99]
Kato S, Osaki T, Kamiya S, Zhang XS, Blaser MJ. Helicobacter pylori sabA gene is associated with iron deficiency anemia in childhood and adolescence. PLoS One  2017; 12(8): e0184046.
 [http://dx.doi.org/10.1371/journal.pone.0184046] [PMID:  28854239]

[100]
Kato S, Gold BD, Kato A. Helicobacter pylori-associated iron deficiency anemia in childhood and adolescence-pathogenesis and clinical management strategy. J Clin Med  2022; 11(24): 7351.
 [http://dx.doi.org/10.3390/jcm11247351] [PMID:  36555966]

[101]
Hudak L, Jaraisy A, Haj S, Muhsen K. An updated systematic review and meta-analysis on the association between Helicobacter pylori infection and iron deficiency anemia. Helicobacter  2017; 22(1): e12330.
 [http://dx.doi.org/10.1111/hel.12330] [PMID:  27411077]

[102]
Uçar HN, Aydin Köker S, Tekin U. Irritability and perceived expressed emotion in adolescents with iron deficiency and iron deficiency anemia: A case-control study. J Pediatr Hematol Oncol  2020; 42(6): 403-9.
 [http://dx.doi.org/10.1097/MPH.0000000000001663] [PMID:  31725544]

[103]
Hetzel TM, Losek JD. Unrecognized severe anemia in children presenting with respiratory distress. Am J Emerg Med  1998; 16(4): 386-9.
 [http://dx.doi.org/10.1016/S0735-6757(98)90135-8] [PMID:  9672458]

[104]
Halis H, Bor-Kucukatay M, Akın M, Kucukatay V, Bozbay İ, Polat A. Hemorheological parameters in children with iron-deficiency anemia and the alterations in these parameters in response to iron replacement. Pediatr Hematol Oncol  2009; 26(3): 108-18.
 [http://dx.doi.org/10.1080/08880010902754909] [PMID:  19382032]

[105]
Iio K, Ishida Y. Blue sclera in an infant with severe iron deficiency anemia. J Pediatr  2022; 247: 169-70.
 [http://dx.doi.org/10.1016/j.jpeds.2022.05.031] [PMID:  35598645]

[106]
Starn AL, Udall JN Jr. Iron deficiency anemia, pica, and restless legs syndrome in a teenage girl. Clin Pediatr (Phila)  2008; 47(1): 83-5.
 [http://dx.doi.org/10.1177/0009922807303930] [PMID:  17641119]

[107]
Anthony R, Sood S, Strachan DR, Fenwick JD. A case of Plummer-Vinson syndrome in childhood. J Pediatr Surg  1999; 34(10): 1570-2.
 [http://dx.doi.org/10.1016/S0022-3468(99)90134-3] [PMID:  10549778]

[108]
Devine K, Friehling E. Dysphagia in an adolescent with iron deficiency anemia. Pediatr Rev  2021; 42(9): 518-21.
 [http://dx.doi.org/10.1542/pir.2020-000745] [PMID:  34470873]

[109]
Youdim MBH, Ben-Shachar D, Yehuda S. Putative biological mechanisms of the effect of iron deficiency on brain biochemistry and be-havior. Am J Clin Nutr  1989; 50(3) (Suppl.): 607-17.
 [http://dx.doi.org/10.1093/ajcn/50.3.607] [PMID:  2773840]

[110]
Sundararajan S, Rabe H. Prevention of iron deficiency anemia in infants and toddlers. Pediatr Res  2021; 89(1): 63-73.
 [http://dx.doi.org/10.1038/s41390-020-0907-5] [PMID:  32330927]

[111]
Zheng J, Liu J, Yang W. Association of iron-deficiency anemia and non-iron-deficiency anemia with neurobehavioral development in children aged 6-24 months. Nutrients  2021; 13(10): 3423.
 [http://dx.doi.org/10.3390/nu13103423] [PMID:  34684422]

[112]
Agaoglu L, Torun O, Unuvar E, Sefil Y, Demir D. Effects of iron deficiency anemia on cognitive function in children. Arzneimittelforschung  2011; 57(6): 426-30.
 [http://dx.doi.org/10.1055/s-0031-1296691] [PMID:  17691592]

[113]
Algarín C, Nelson CA, Peirano P, Westerlund A, Reyes S, Lozoff B. Iron-deficiency anemia in infancy and poorer cognitive inhibitory control at age 10 years. Dev Med Child Neurol  2013; 55(5): 453-8.
 [http://dx.doi.org/10.1111/dmcn.12118] [PMID:  23464736]

[114]
Black MM, Quigg AM, Hurley KM, Pepper MR. Iron deficiency and iron-deficiency anemia in the first two years of life: strategies to pre-vent loss of developmental potential. Nutr Rev  2011; 69 (Suppl. 1): S64-70.
 [http://dx.doi.org/10.1111/j.1753-4887.2011.00435.x] [PMID:  22043885]

[115]
Bruner AB, Joffe A, Duggan AK, Casella JF, Brandt J. Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls. Lancet  1996; 348(9033): 992-6.
 [http://dx.doi.org/10.1016/S0140-6736(96)02341-0] [PMID:  8855856]

[116]
Carter RC, Jacobson JL, Burden MJ, et al. Iron deficiency anemia and cognitive function in infancy. Pediatrics  2010; 126(2): e427-34.
 [http://dx.doi.org/10.1542/peds.2009-2097] [PMID:  20660551]

[117]
Idjradinata P, Pollitt E. Reversal of developmental delays in iron-deficient anaemic infants treated with iron. Lancet  1993; 341(8836): 1-4.
 [http://dx.doi.org/10.1016/0140-6736(93)92477-B] [PMID:  7678046]

[118]
Lozoff B, Klein NK, Nelson EC, McClish DK, Manuel M, Chacon ME. Behavior of infants with iron-deficiency anemia. Child Dev  1998; 69(1): 24-36.
 [http://dx.doi.org/10.1111/j.1467-8624.1998.tb06130.x] [PMID:  9499554]

[119]
Lozoff B, Beard J, Connor J, Felt B, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev  2006; 64(5): 34-43.
 [http://dx.doi.org/10.1301/nr.2006.may.S34-S43] [PMID:  16770951]

[120]
McCann JC, Ames BN. An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function. Am J Clin Nutr  2007; 85(4): 931-45.
 [http://dx.doi.org/10.1093/ajcn/85.4.931] [PMID:  17413089]

[121]
Pala E, Erguven M, Guven S, Erdogan M, Balta T. Psychomotor development in children with iron deficiency and iron-deficiency anemia. Food Nutr Bull  2010; 31(3): 431-5.
 [http://dx.doi.org/10.1177/156482651003100305] [PMID:  20973463]

[122]
Walter T, De Andraca I, Chadud P, Perales CG. Iron deficiency anemia: adverse effects on infant psychomotor development. Pediatrics  1989; 84(1): 7-17.
 [http://dx.doi.org/10.1542/peds.84.1.7] [PMID:  2472596]

[123]
Chang S, Wang L, Wang Y, et al. Iron-deficiency anemia in infancy and social emotional development in preschool-aged Chinese children. Pediatrics  2011; 127(4): e927-33.
 [http://dx.doi.org/10.1542/peds.2010-1659] [PMID:  21402624]

[124]
Gupta SK, Bansal D, Malhi P, Das R. Developmental profile in children with iron deficiency anemia and its changes after therapeutic iron supplementation. Indian J Pediatr  2010; 77(4): 375-9.
 [http://dx.doi.org/10.1007/s12098-010-0046-9] [PMID:  20428973]

[125]
Chung SD, Chen PY, Lin HC, Hung SH. Sudden sensorineural hearing loss associated with iron-deficiency anemia: a populationbased study. JAMA Otolaryngol Head Neck Surg  2014; 140(5): 417-22.
 [http://dx.doi.org/10.1001/jamaoto.2014.75] [PMID:  24626300]

[126]
Jain C, Pushpoth Gangadharan VG, Kadabasal Basavaraja C, Lakshmi A. Relationship between peripheral and central auditory abilities and iron deficiency anemia in adolescent girls. Am J Audiol  2021; 30(4): 1037-47.
 [http://dx.doi.org/10.1044/2021_AJA-21-00036] [PMID:  34662243]

[127]
Schieffer KM, Connor JR, Pawelczyk JA, Sekhar DL. The relationship between iron deficiency anemia and sensorineural hearing loss in the pediatric and adolescent population. Am J Audiol  2017; 26(2): 155-62.
 [http://dx.doi.org/10.1044/2017_AJA-16-0093] [PMID:  28492865]

[128]
Sundagumaran H, Seethapathy J. Auditory brainstem response in infants with iron deficiency anemia. Int J Pediatr Otorhinolaryngol  2019; 117: 78-81.
 [http://dx.doi.org/10.1016/j.ijporl.2018.11.017] [PMID:  30579094]

[129]
Ballin A, Berar M, Rubinstein U, Kleter Y, Hershkovitz A, Meytes D. Iron state in female adolescents. Arch Pediatr Adolesc Med  1992; 146(7): 803-5.
 [http://dx.doi.org/10.1001/archpedi.1992.02160190035015] [PMID:  1496946]

[130]
Burden MJ, Westerlund AJ, Armony-Sivan R, et al. An eventrelated potential study of attention and recognition memory in infants with iron-deficiency anemia. Pediatrics  2007; 120(2): e336-45.
 [http://dx.doi.org/10.1542/peds.2006-2525] [PMID:  17671043]

[131]
East PL, Doom JR, Blanco E, Burrows R, Lozoff B, Gahagan S. Iron deficiency in infancy and sluggish cognitive tempo and ADHD symp-toms in childhood and adolescence. J Clin Child Adolesc Psychol  2021; 52(2): 1-12.
 [http://dx.doi.org/10.1080/15374416.2021.1969653] [PMID:  34519599]

[132]
Islam K, Seth S, Saha S, Roy A, Das R, Datta A. A study on association of iron deficiency with attention deficit hyperactivity disorder in a tertiary care center. Indian J Psychiatry  2018; 60(1): 131-4.
 [http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_197_17] [PMID:  29736076]

[133]
Leung AKC, Hon KL. Attention-Deficit/Hyperactivity Disorder. Adv Pediatr  2016; 63(1): 255-80.
 [http://dx.doi.org/10.1016/j.yapd.2016.04.017] [PMID:  27426904]

[134]
Oski FA, Honig AS, Helu B, Howanitz P. Effect of iron therapy on behavior performance in nonanemic, iron-deficient infants. Pediatrics  1983; 71(6): 877-80.
 [http://dx.doi.org/10.1542/peds.71.6.877] [PMID:  6856400]

[135]
Chen MH, Su TP, Chen YS, et al. Association between psychiatric disorders and iron deficiency anemia among children and adolescents: a nationwide population-based study. BMC Psychiatry  2013; 13(1): 161.
 [http://dx.doi.org/10.1186/1471-244X-13-161] [PMID:  23735056]

[136]
Cortese S, Azoulay R, Castellanos FX, et al. Brain iron levels in attention-deficit/hyperactivity disorder: A pilot MRI study. World J Biol Psychiatry  2012; 13(3): 223-31.
 [http://dx.doi.org/10.3109/15622975.2011.570376] [PMID:  21585274]

[137]
Shvarzman R, Crocetti D, Rosch KS, Li X, Mostofsky SH. Reduced basal ganglia tissue-iron concentration in school-age children with attention-deficit/hyperactivity disorder is localized to limbic circuitry. Exp Brain Res  2022; 240(12): 3271-88.
 [http://dx.doi.org/10.1007/s00221-022-06484-7] [PMID:  36301336]

[138]
Choi JW, Kim SK. Association of serum insulin-like growth factor-I and erythropoiesis in relation to body iron status. Ann Clin Lab Sci  2004; 34(3): 324-8.
 [PMID:  15487708]

[139]
Moy RJD, Early AR. Iron deficiency in childhood. J R Soc Med  1999; 92(5): 234-6.
 [http://dx.doi.org/10.1177/014107689909200505] [PMID:  10472258]

[140]
Soliman AT, Al Dabbagh MM, Habboub AH, Adel A, Humaidy NA, Abushahin A. Linear growth in children with iron deficiency anemia before and after treatment. J Trop Pediatr  2009; 55(5): 324-7.
 [http://dx.doi.org/10.1093/tropej/fmp011] [PMID:  19261662]

[141]
Angeles IT, Schultink WJ, Matulessi P, Gross R, Sastroamidjojo S. Decreased rate of stunting among anemic Indonesian preschool chil-dren through iron supplementation. Am J Clin Nutr  1993; 58(3): 339-42.
 [http://dx.doi.org/10.1093/ajcn/58.3.339] [PMID:  8237843]

[142]
Aukett MA, Parks YA, Scott PH, Wharton BA. Treatment with iron increases weight gain and psychomotor development. Arch Dis Child  1986; 61(9): 849-57.
 [http://dx.doi.org/10.1136/adc.61.9.849] [PMID:  2429622]

[143]
Chwang LC, Soemantri AG, Pollitt E. Iron supplementation and physical growth of rural Indonesian children. Am J Clin Nutr  1988; 47(3): 496-501.
 [http://dx.doi.org/10.1093/ajcn/47.3.496] [PMID:  3348161]

[144]
El-Hawy MA, Abd Al-Salam SA, Bahbah WA. Comparing oral iron bisglycinate chelate, lactoferrin, lactoferrin with iron and iron poly-maltose complex in the treatment of children with iron deficiency anemia. Clin Nutr ESPEN  2021; 46: 367-71.
 [http://dx.doi.org/10.1016/j.clnesp.2021.08.040] [PMID:  34857222]

[145]
Sharif MR, Kheirkhah D, Madani M, Kashani HH. The relationship between iron deficiency and febrile convulsion: a case-control study. Glob J Health Sci  2015; 8(2): 185-9.
 [http://dx.doi.org/10.5539/gjhs.v8n2p185] [PMID:  26383191]

[146]
Bhatia D, Seshadri S. Anemia, undernutrition and physical work capacity of young boys. Indian Pediatr  1987; 24(2): 133-9.
 [PMID:  3666941]

[147]
Edgerton VR, Gardner GW, Ohira Y, Gunawardena KA, Senewiratne B. Iron-deficiency anaemia and its effect on worker productivity and activity patterns. BMJ  1979; 2(6204): 1546-9.
 [http://dx.doi.org/10.1136/bmj.2.6204.1546] [PMID:  534861]

[148]
Gardner GW, Edgerton VR, Senewiratne B, Barnard RJ, Ohira Y. Physical work capacity and metabolic stress in subjects with iron defi-ciency anemia. Am J Clin Nutr  1977; 30(6): 910-7.
 [http://dx.doi.org/10.1093/ajcn/30.6.910] [PMID:  868783]

[149]
Rowland TW, Deisroth MB, Green GM, Kelleher JF. The effect of iron therapy on the exercise capacity of nonanemic iron-deficient ado-lescent runners. Arch Pediatr Adolesc Med  1988; 142(2): 165-9.
 [http://dx.doi.org/10.1001/archpedi.1988.02150020067030] [PMID:  3341317]

[150]
Zhu YI, Haas JD. Iron depletion without anemia and physical performance in young women. Am J Clin Nutr  1997; 66(2): 334-41.
 [http://dx.doi.org/10.1093/ajcn/66.2.334] [PMID:  9250112]

[151]
Bay A, Dogan M, Bulan K, Kaba S, Demir N, Öner AF. A study on the effects of pica and iron-deficiency anemia on oxidative stress, antioxidant capacity and trace elements. Hum Exp Toxicol  2013; 32(9): 895-903.
 [http://dx.doi.org/10.1177/0960327113475676] [PMID:  23444335]

[152]
Leung AKC, Hon KL. Pica: A common condition that is commonly missed - An update review. Curr Pediatr Rev  2019; 15(3): 164-9.
 [http://dx.doi.org/10.2174/1573396315666190313163530] [PMID:  30868957]

[153]
Osman YM, Wali YA, Osman OM. Craving for ice and iron-deficiency anemia: a case series from Oman. Pediatr Hematol Oncol  2005; 22(2): 127-31.
 [http://dx.doi.org/10.1080/08880010590896486] [PMID:  15804997]

[154]
Moore DF Jr, Sears DA. Pica, iron deficiency, and the medical history. Am J Med  1994; 97(4): 390-3.
 [http://dx.doi.org/10.1016/0002-9343(94)90309-3] [PMID:  7942944]

[155]
Nemeth J, Hwang P. Pica? Check a hemoglobin. Iron deficiency anemia? Ask about pica. CJEM  2021; 23(4): 556-7.
 [http://dx.doi.org/10.1007/s43678-021-00134-7] [PMID:  33884587]

[156]
Borgna-Pignatti C, Zanella S. Pica as a manifestation of iron deficiency. Expert Rev Hematol  2016; 9(11): 1075-80.
 [http://dx.doi.org/10.1080/17474086.2016.1245136] [PMID:  27701928]

[157]
McDonald R, Marshall SR. The value of iron therapy in pica. Pediatrics  1964; 34(4): 558-62.
 [http://dx.doi.org/10.1542/peds.34.4.558] [PMID:  14212472]

[158]
Hauptman M, Bruccoleri R, Woolf AD. An update on childhood lead poisoning. Clin Pediatr Emerg Med  2017; 18(3): 181-92.
 [http://dx.doi.org/10.1016/j.cpem.2017.07.010] [PMID:  29056870]

[159]
Ekiz C, Agaoglu L, Karakas Z, Gurel N, Yalcin I. The effect of iron deficiency anemia on the function of the immune system. Hematol J  2005; 5(7): 579-83.
 [http://dx.doi.org/10.1038/sj.thj.6200574] [PMID:  15692603]

[160]
Hassan TH, Badr MA, Karam NA, et al. Impact of iron deficiency anemia on the function of the immune system in children. Medicine (Baltimore)  2016; 95(47): e5395.
 [http://dx.doi.org/10.1097/MD.0000000000005395] [PMID:  27893677]

[161]
Macdougall LG, Anderson R, McNab GM, Katz J. The immune response in iron-deficient children: Impaired cellular defense mechanisms with altered humoral components. J Pediatr  1975; 86(6): 833-43.
 [http://dx.doi.org/10.1016/S0022-3476(75)80211-3] [PMID:  1127523]

[162]
Reeves JD, Yip R, Kiley VA, Dallman PR. Iron deficiency in infants: The influence of mild antecedent infection. J Pediatr  1984; 105(6): 874-9.
 [http://dx.doi.org/10.1016/S0022-3476(84)80069-4] [PMID:  6502335]

[163]
Stoffel NU, Uyoga MA, Mutuku FM, et al. Iron deficiency anemia at time of vaccination predicts decreased vaccine response and iron supplementation at time of vaccination increases humoral vaccine response: A birth cohort study and a randomized trial follow-up study in Kenyan infants. Front Immunol  2020; 11: 1313.
 [http://dx.doi.org/10.3389/fimmu.2020.01313] [PMID:  32754150]

[164]
Bhatia MS, Singhal PK, Dhar NK, Nigam VR, Malik SC, Mullick DN. Breath holding spells: an analysis of 50 cases. Indian Pediatr  1990; 27(10): 1073-9.
 [PMID:  2090594]

[165]
Bidabadi E, Poornabi Darzi S, Mashouf P, Shahraki T. Effectiveness of iron therapy on breath holding spells in the children. Iran J Child Neurol  2019; 13(4): 155-61.
 [PMID:  31645875]

[166]
Gürbüz G, Perk P, Çokyaman T, Gürbüz ÖB. Iron supplementation should be given in breath-holding spells regardless of anemia. Turk J Med Sci  2019; 49(1): 230-7.
 [http://dx.doi.org/10.3906/sag-1805-92] [PMID:  30761881]

[167]
Leung AKC, Leung AAM, Wong AHC, Hon KL. Breath-holding spells in pediatrics: A narrative review of the current evidence. Curr Pediatr Rev  2019; 15(1): 22-9.
 [http://dx.doi.org/10.2174/1573396314666181113094047] [PMID:  30421679]

[168]
Mocan H, Yildiran A, Orhan F, Erduran E. Breath holding spells in 91 children and response to treatment with iron. Arch Dis Child  1999; 81(3): 261-2.
 [http://dx.doi.org/10.1136/adc.81.3.261] [PMID:  10451402]

[169]
Yilmaz S, Kükner Ç. Anemia in children with breath-holding spells. J Pediatr  1996; 128(3): 440-1.
 [http://dx.doi.org/10.1016/S0022-3476(96)70310-4] [PMID:  8774524]

[170]
Dai AI, Demiryürek AT. Effectiveness oral theophylline, piracetam, and iron treatments in children with simple breath-holding spells. J Child Neurol  2020; 35(1): 25-30.
 [http://dx.doi.org/10.1177/0883073819871854] [PMID:  31502508]

[171]
Hamed SA, Gad EF, Sherif TK. Iron deficiency and cyanotic breath-holding spells: The effectiveness of iron therapy. Pediatr Hematol Oncol  2018; 35(3): 186-95.
 [http://dx.doi.org/10.1080/08880018.2018.1491659] [PMID:  30351985]

[172]
Jain R, Omanakuttan D, Singh A, Jajoo M. Effect of iron supplementation in children with breath holding spells. J Paediatr Child Health  2017; 53(8): 749-53.
 [http://dx.doi.org/10.1111/jpc.13556] [PMID:  28568906]

[173]
Zehetner AA, Orr N, Buckmaster A, Williams K, Wheeler DM. Iron supplementation for breath-holding attacks in children. Cochrane Libr  2010; (5): CD008132.
 [http://dx.doi.org/10.1002/14651858.CD008132.pub2] [PMID:  20464763]

[174]
Aziz KT, Ahmed N, Nagi AG. Iron deficiency anaemia as risk factor for simple febrile seizures: A case control study. J Ayub Med Coll Abbottabad  2017; 29(2): 316-9.
 [PMID:  28718256]

[175]
Karmacharya Malla K, Gaire B, Gaire B. Association of iron deficiency anemia with febrile seizure in children in a tertiary care hospital. J Nepal Health Res Counc  2021; 19(1): 66-70.
 [http://dx.doi.org/10.33314/jnhrc.v19i1.3327] [PMID:  33934135]

[176]
Habibian N, Alipour A, Rezaianzadeh A. Association between iron deficiency anemia and febrile convulsion in 3- to 60-month-old chil-dren: A systematic review and meta-analysis. Iran J Med Sci  2014; 39(6): 496-505.
 [PMID:  25429171]

[177]
Köksal AO, Özdemir O, Büyükkaragöz B, Karaömerlioglu M, Bulus AD. The association between plasma ferritin level and simple febrile seizures in children. J Pediatr Hematol Oncol  2016; 38(7): 512-6.
 [http://dx.doi.org/10.1097/MPH.0000000000000646] [PMID:  27467370]

[178]
Leung AKC, Robson WLM. Febrile Seizures. J Pediatr Health Care  2007; 21(4): 250-5.
 [http://dx.doi.org/10.1016/j.pedhc.2006.10.006] [PMID:  17606162]

[179]
Leung AKC, Hon KL, Leung TNH. Febrile seizures: an overview. Drugs Context  2018; 7: 1-12.
 [http://dx.doi.org/10.7573/dic.212536] [PMID:  30038660]

[180]
Naveed-ur-Rehman. Billoo AG. Association between iron deficiency anemia and febrile seizures. J Coll Physicians Surg Pak  2005; 15(6): 338-40.
 [PMID:  15924837]

[181]
Papageorgiou V, Vargiami E, Kontopoulos E, et al. Association between iron deficiency and febrile seizures. Eur J Paediatr Neurol  2015; 19(5): 591-6.
 [http://dx.doi.org/10.1016/j.ejpn.2015.05.009] [PMID:  26112262]

[182]
Pisacane A, Sansone R, Impagliazzo N, et al. Iron deficiency anaemia and febrile convulsions: case-control study in children under 2 years. BMJ  1996; 313(7053): 343.
 [http://dx.doi.org/10.1136/bmj.313.7053.343] [PMID:  8760744]

[183]
Rudy M, Mayer-Proschel M. Iron deficiency affects seizure susceptibility in a time- and sex-specific manner. ASN Neuro  2017; 9(6)
 [http://dx.doi.org/10.1177/1759091417746521] [PMID:  29243938]

[184]
Shafir T, Angulo-Barroso R, Su J, Jacobson SW, Lozoff B. Iron deficiency anemia in infancy and reach and grasp development. Infant Behav Dev  2009; 32(4): 366-75.
 [http://dx.doi.org/10.1016/j.infbeh.2009.06.002] [PMID:  19592115]

[185]
Sharafkhah M, Firouzifar M, Zolfi M, Yousefichaijan P, Eghbali A, Rafeie M. The relationship between iron deficiency anemia and simple febrile convulsion in children. J Pediatr Neurosci  2014; 9(2): 110-4.
 [http://dx.doi.org/10.4103/1817-1745.139276] [PMID:  25250062]

[186]
Kwak BO, Kim K, Kim SN, Lee R. Relationship between iron deficiency anemia and febrile seizures in children: A systematic review and meta-analysis. Seizure  2017; 52: 27-34.
 [http://dx.doi.org/10.1016/j.seizure.2017.09.009] [PMID:  28957722]

[187]
Azab SFA, Abdelsalam SM, Saleh SHA, et al. Iron deficiency anemia as a risk factor for cerebrovascular events in early childhood: a case–control study. Ann Hematol  2014; 93(4): 571-6.
 [http://dx.doi.org/10.1007/s00277-013-1922-y] [PMID:  24141332]

[188]
Basak R, Chowdhury A, Fatmi L, Saha N, Mollah A, Yasmin S. Stroke in the young: relationship with iron deficiency anemia and throm-bocytosis. Mymensingh Med J  2008; 17(1): 74-7.
 [PMID:  18285738]

[189]
Ghosh PS, Plautz G, Cerejo R, Moodley M. Cerebral venous sinus thrombosis in a child with iron-deficiency anemia. Acta Neurol Belg  2014; 114(2): 131-2.
 [http://dx.doi.org/10.1007/s13760-013-0195-5] [PMID:  23553265]

[190]
Hartfield DS, Lowry NJ, Keene DL, Yager JY. Iron deficiency: A cause of stroke in infants and children. Pediatr Neurol  1997; 16(1): 50-3.
 [http://dx.doi.org/10.1016/S0887-8994(96)00290-1] [PMID:  9044402]

[191]
Kılcı C, Olcay L, Özdemir B, Fettah A, Çolak MY. Children with iron deficiency anemia have a tendency to hypercoagulation: An evalua-tion by thromboelastography. Turk J Haematol  2019; 37(1): 59-62.
 [http://dx.doi.org/10.4274/tjh.galenos.2019.2019.0027] [PMID:  31852173]

[192]
Maguire JL, deVeber G, Parkin PC. Association between iron-deficiency anemia and stroke in young children. Pediatrics  2007; 120(5): 1053-7.
 [http://dx.doi.org/10.1542/peds.2007-0502] [PMID:  17974743]

[193]
Subedi K, Koirala S, Basnet R, Poudel A. Paediatric stroke: A rare presentation of iron deficiency anemia in a four year old child. Kathmandu Univ Med J  2016; 14(55): 282-384. [KUMJ].
 [PMID: 28814695]

[194]
Özdemir ZC, Düzenli Kar Y, Gündüz E, Turhan AB, Bör Ö. Evaluation of hypercoagulability with rotational thromboelastometry in chil-dren with iron deficiency anemia. Hematology  2018; 23(9): 664-8.
 [http://dx.doi.org/10.1080/10245332.2018.1452456] [PMID:  29544395]

[195]
Saxena K, Ranalli M, Khan N, Blanchong C, Kahwash SB. Fatal stroke in a child with severe iron deficiency anemia and multiple heredi-tary risk factors for thrombosis. Clin Pediatr  2005; 44(2): 175-80.
 [http://dx.doi.org/10.1177/000992280504400210]

[196]
Güneş A, Ece A, Aktar F, et al. Urinary kidney injury molecules in children with iron-deficiency anemia. Med Sci Monit  2015; 21: 4023-9.
 [http://dx.doi.org/10.12659/MSM.896794] [PMID:  26697893]

[197]
Hassan NE. Reply: Intravenous ferumoxytol in pediatric patients with iron-deficiency anemia. Ann Pharmacother  2017; 51(12): 1146.
 [http://dx.doi.org/10.1177/1060028017726796] [PMID:  28831808]

[198]
Shalby KY, Alradhi AY, Holdar SJ, et al. Extremes of anemia: The lowest hemoglobin values probably ever reported in the pediatric lit-erature attributed to iron deficiency anemia. Am J Case Rep  2022; 23: e936252.
 [http://dx.doi.org/10.12659/AJCR.936252] [PMID:  35768994]

[199]
Abioye AI, Aboud S, Premji Z, et al. Hemoglobin and hepcidin have good validity and utility for diagnosing iron deficiency anemia among pregnant women. Eur J Clin Nutr  2020; 74(5): 708-19.
 [http://dx.doi.org/10.1038/s41430-019-0512-z] [PMID:  31624364]

[200]
Mirza FG, Abdul-Kadir R, Breymann C, Fraser IS, Taher A. Impact and management of iron deficiency and iron deficiency anemia in women’s health. Expert Rev Hematol  2018; 11(9): 727-36.
 [http://dx.doi.org/10.1080/17474086.2018.1502081] [PMID:  30019973]

[201]
Murphy JF, Newcombe RG, O’Riordan J, Coles EC, Pearson JF. Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. Lancet  1986; 327(8488): 992-5.
 [http://dx.doi.org/10.1016/S0140-6736(86)91269-9] [PMID:  2871331]

[202]
Scholl TO, Hediger ML, Fischer RL, Shearer JW. Anemia vs iron deficiency: increased risk of preterm delivery in a prospective study. Am J Clin Nutr  1992; 55(5): 985-8.
 [http://dx.doi.org/10.1093/ajcn/55.5.985] [PMID:  1570808]

[203]
Graham EA. The changing face of anemia in infancy. Pediatr Rev  1994; 15(5): 175-83.
 [http://dx.doi.org/10.1542/pir.15.5.175] [PMID:  8036193]

[204]
Cohen AR. Choosing the best strategy to prevent childhood iron deficiency. JAMA  1999; 281(23): 2247-8.
 [http://dx.doi.org/10.1001/jama.281.23.2247] [PMID:  10376581]

[205]
Schaefer RM, Schaefer L. Hypochromic red blood cells and reticulocytes. Kidney Int  1999; 55: S44-8.
 [http://dx.doi.org/10.1046/j.1523-1755.1999.055Suppl.69044.x] [PMID:  10084285]

[206]
Al-Numan AH, Al-Obeidi RA. The value of the red cell distribution width index versus other parameters in the differentiation between iron deficiency anemia and beta thalassemia trait among children in Mosul, Iraq. Expert Rev Hematol  2021; 14(4): 401-6.
 [http://dx.doi.org/10.1080/17474086.2021.1905514] [PMID:  33736549]

[207]
Massey AC. Microcytic anemia. Differential diagnosis and management of iron deficiency anemia. Med Clin North Am  1992; 76(3): 549-66.
 [http://dx.doi.org/10.1016/S0025-7125(16)30339-X] [PMID:  1578956]

[208]
Short MW, Domagalski JE. Iron deficiency anemia: evaluation and management. Am Fam Physician  2013; 87(2): 98-104.
 [PMID:  23317073]

[209]
Chun S, Jeon JS, Lee MJ. Serum hepcidin to prohepcidin ratio in children with iron deficiency anemia. Ann Clin Lab Sci  2019; 49(5): 639-44.
 [PMID:  31611207]

[210]
Wang F, Wang G, Yang Z, et al. Differential diagnosis of thalassemia and iron deficiency anemia using the CellaVision Advanced Red Blood Cell software. Int J Lab Hematol  2021; 43(4): 853-8.
 [http://dx.doi.org/10.1111/ijlh.13424] [PMID:  33342061]

[211]
Düzenli Kar Y, Özdemir ZC, Emir B, Bör Ö. Erythrocyte indices as differential diagnostic biomarkers of iron deficiency anemia and thalassemia. J Pediatr Hematol Oncol  2020; 42(3): 208-13.
 [http://dx.doi.org/10.1097/MPH.0000000000001597] [PMID:  31568184]

[212]
Wee SY, Muhamed Said SS, Raja Sabudin RZA, Alauddin H, Ithnin A. Microcytic to hypochromic ratio as a discriminant index of thalassaemia trait in subjects with hypochromic anaemia. Malays J Pathol  2020; 42(2): 195-201.
 [PMID:  32860371]

[213]
Nalbantoğlu B, Güzel S, Büyükyalçın V, et al. Indices used in differentiation of thalassemia trait from iron deficiency anemia in pediatric population: are they reliable? Pediatr Hematol Oncol  2012; 29(5): 472-8.
 [http://dx.doi.org/10.3109/08880018.2012.705230] [PMID:  22866672]

[214]
Dapul H, Laraque D. Lead poisoning in children. Adv Pediatr  2014; 61(1): 313-33.
 [http://dx.doi.org/10.1016/j.yapd.2014.04.004] [PMID:  25037135]

[215]
Hon KL, Fung CK, Leung AKC. Childhood lead poisoning: an overview. Hong Kong Med J  2017; 23(6): 616-21.
 [http://dx.doi.org/10.12809/hkmj176214] [PMID:  29026055]

[216]
Markowitz M. Lead poisoning: An update. Pediatr Rev  2021; 42(6): 302-15.
 [http://dx.doi.org/10.1542/pir.2020-0026] [PMID:  34074717]

[217]
Mayans L. Lead poisoning in children. Am Fam Physician  2019; 100(1): 24-30.
 [PMID:  31259498]

[218]
Leung AKC, Robson WLM, Fagan JE, Lim SHN. Attention-deficit hyperactivity disorder. Postgrad Med  1994; 95(2): 153-60.
 [http://dx.doi.org/10.1080/00325481.1994.11945799] [PMID:  8309858]

[219]
Yamaguchi T, Yamagami K. Burton’s line: a sign of chronic lead poisoning. QJM  2021; 114(10): 752.
 [http://dx.doi.org/10.1093/qjmed/hcab192] [PMID:  34264343]

[220]
Bain BJ. Lead poisoning. Am J Hematol  2014; 89(12): 1141.
 [http://dx.doi.org/10.1002/ajh.23852] [PMID:  25220013]

[221]
Zhao Y, Lv J. Basophilic stippling and chronic lead poisoning. Turk J Haematol  2018; 35(4): 298-9.
 [http://dx.doi.org/10.4274/tjh.2018.0195] [PMID:  30182925]

[222]
Svenson N, Bailey J, Durairaj S, Dempsey-Hibbert N. A simplified diagnostic pathway for the differential diagnosis of iron deficiency anaemia and anaemia of chronic disease. Int J Lab Hematol  2021; 43(6): 1644-52.
 [http://dx.doi.org/10.1111/ijlh.13666] [PMID:  34288431]

[223]
Wiciński M, Liczner G, Cadelski K, Kołnierzak T, Nowaczewska M, Malinowski B. Anemia of chronic diseases: Wider diagnostics-better treatment? Nutrients  2020; 12(6): 1784.
 [http://dx.doi.org/10.3390/nu12061784] [PMID:  32560029]

[224]
Hanina S, Bain BJ, Clark B, Layton DM. Congenital sideroblastic anemia in a female. Am J Hematol  2018; 93(9): 1181-2.
 [http://dx.doi.org/10.1002/ajh.25196] [PMID:  30040160]

[225]
Bottomley SS, Fleming MD. Sideroblastic anemia: diagnosis and management. Hematol Oncol Clin North Am  2014; 28(4): 653-70.
 [http://dx.doi.org/10.1016/j.hoc.2014.04.008]

[226]
Ashorobi D, Chhabra A. Sideroblastic anemia. In: StatPearls. Treasure Island, FL: StatPearls Publishing 2022.

[227]
Aleem A, Alsayegh F, Keshav S, et al. Consensus statement by an expert panel on the diagnosis and management of iron deficiency anemia in the Gulf Cooperation Council Countries. Med Princ Pract  2020; 29(4): 371-81.
 [http://dx.doi.org/10.1159/000503707] [PMID:  31698356]

[228]
Pachuta Węgier L, Kubiak M, Liebert A, et al. Ferrous sulfate oral solution in young children with iron deficiency anemia: An open‐label trial of efficacy, safety, and acceptability. Pediatr Int  2020; 62(7): 820-7.
 [http://dx.doi.org/10.1111/ped.14237] [PMID:  32191814]

[229]
Penagini F, Abbattista L, Borsani B, Ramponi G, D’Auria E, Zuccotti GV. Iron deficiency and iron deficiency anemia in children aged 6–36 months: Is there room for improvement of screening, prophylaxis and treatment? Pharmacol Res  2018; 128: 61-2.
 [http://dx.doi.org/10.1016/j.phrs.2017.12.012] [PMID:  29258914]

[230]
Powers JM. Iron deficiency in infants and children <12 years: Treatment.In: Post, TW, ed UpToDate Waltham, MA (Accessed on March 20, 2023). 

[231]
Chandra J. Treating iron deficiency anemia. Indian J Pediatr  2019; 86(12): 1085-6.
 [http://dx.doi.org/10.1007/s12098-019-03107-y] [PMID:  31713209]

[232]
Aydin A, Gur E, Erener-Ercan T, Can G, Arvas A. Comparison of different iron preparations in the prophylaxis of iron-deficiency anemia. J Pediatr Hematol Oncol  2017; 39(7): 495-9.
 [http://dx.doi.org/10.1097/MPH.0000000000000967] [PMID:  28872486]

[233]
Bailie G. Efficacy and safety of ferric carboxymaltose in correcting iron-deficiency anemia: a review of randomized controlled trials across different indications. Arzneimittelforschung  2011; 60(6): 386-98.
 [http://dx.doi.org/10.1055/s-0031-1296303] [PMID:  20648930]

[234]
Bopche AV, Dwivedi R, Mishra R, Patel GS. Ferrous sulfate versus iron polymaltose complex for treatment of iron deficiency anemia in children. Indian Pediatr  2009; 46(10): 883-5.
 [PMID:  19430060]

[235]
Jaber L, Rigler S, Taya A, et al. Iron polymaltose versus ferrous gluconate in the prevention of iron deficiency anemia of infancy. J Pediatr Hematol Oncol  2010; 32(8): 585-8.
 [http://dx.doi.org/10.1097/MPH.0b013e3181ec0f2c] [PMID:  20930652]

[236]
Kinlin LM, Talarico S, Kirby M, Parkin PC. A toddler with iron deficiency anemia unresponsive to oral iron treatment. CMAJ  2020; 192(15): E393-6.
 [http://dx.doi.org/10.1503/cmaj.191008] [PMID:  32392500]

[237]
Omar OM, Assem H, Ahmed D, Abd Elmaksoud MS. Lactoferrin versus iron hydroxide polymaltose complex for the treatment of iron deficiency anemia in children with cerebral palsy: a randomized controlled trial. Eur J Pediatr  2021; 180(8): 2609-18.
 [http://dx.doi.org/10.1007/s00431-021-04125-9] [PMID:  34101010]

[238]
Ozsurekci Y, Unal S, Cetin M, Gumruk F. Comparison of ferrous sulfate, polymaltose complex and iron-zinc in iron deficiency anemia. Minerva Pediatr  2019; 71(5): 449-54.
 [http://dx.doi.org/10.23736/S0026-4946.17.04268-2] [PMID:  26200522]

[239]
Patil P, Geevarghese P, Khaire P, et al. Comparison of therapeutic efficacy of ferrous ascorbate and iron polymaltose complex in iron deficiency anemia in children: A randomized controlled trial. Indian J Pediatr  2019; 86(12): 1112-7.
 [http://dx.doi.org/10.1007/s12098-019-03068-2] [PMID:  31520309]

[240]
Auerbach M. Should intravenous iron be upfront therapy for iron deficiency anemia? Pediatr Blood Cancer  2011; 56(4): 511-2.
 [http://dx.doi.org/10.1002/pbc.22981] [PMID:  21298731]

[241]
Okam MM, Koch TA, Tran MH. Iron supplementation, response in iron-deficiency anemia: Analysis of five trials. Am J Med  2017; 130(8): 991.e1-8.
 [http://dx.doi.org/10.1016/j.amjmed.2017.03.045] [PMID:  28454902]

[242]
Akin M, Atay E, Oztekin O, et al. Responsiveness to parenteral iron therapy in children with oral ironrefractory iron-deficiency anemia. Pediatr Hematol Oncol  2014; 31(1): 57-61.
 [http://dx.doi.org/10.3109/08880018.2013.829540] [PMID:  24087940]

[243]
Boucher AA, Bedel A, Jones S, Lenahan SF, Geer R, McGann PT. A retrospective study of the safety and efficacy of low molecular weight iron dextran for children with iron deficiency anemia. Pediatr Blood Cancer  2021; 68(7): e29024.
 [http://dx.doi.org/10.1002/pbc.29024] [PMID:  33769677]

[244]
Butcher A. Comment: Intravenous ferumoxytol in pediatric patients with iron deficiency anemia. Ann Pharmacother  2017; 51(12): 1145.
 [http://dx.doi.org/10.1177/1060028017728523] [PMID:  28925297]

[245]
Cococcioni L, Pensabene L, El-Khouly S, et al. Ferric carboxymaltose treatment for iron deficiency anemia in children with inflammatory bowel disease: Efficacy and risk of hypophosphatemia. Dig Liver Dis  2021; 53(7): 830-4.
 [http://dx.doi.org/10.1016/j.dld.2021.02.017] [PMID:  33775573]

[246]
Gilmartin CE, Hoang T, Cutts BA, Leung L. Retrospective cohort study comparing the adverse reactions and efficacy of intravenous iron polymaltose with ferric carboxymaltose for iron deficiency anemia. Int J Gynaecol Obstet  2018; 141(3): 315-20.
 [http://dx.doi.org/10.1002/ijgo.12476] [PMID:  29498039]

[247]
Hassan N, Boville B, Reischmann D, Ndika A, Sterken D, Kovey K. Intravenous ferumoxytol in pediatric patients with iron deficiency anemia. Ann Pharmacother  2017; 51(7): 548-54.
 [http://dx.doi.org/10.1177/1060028017699429] [PMID:  28622742]

[248]
Hassan RH, Kandil SM, Zeid MS, Zaki ME, Fouda AE. Kidney injury in infants and children with iron-deficiency anemia before and after iron treatment. Hematology  2017; 22(9): 565-70.
 [http://dx.doi.org/10.1080/10245332.2017.1325587] [PMID:  28506129]

[249]
Mantadakis E. Parenteral iron therapy in children with iron deficiency anemia. World J Pediatr  2016; 12(1): 122-3.
 [http://dx.doi.org/10.1007/s12519-015-0010-x] [PMID:  27175456]

[250]
Mantadakis E, Roganovic J. Safety and efficacy of ferric carboxymaltose in children and adolescents with iron deficiency anemia. J Pediatr  2017; 184: 241.
 [http://dx.doi.org/10.1016/j.jpeds.2017.01.041] [PMID:  28196681]

[251]
Motta I, Mantovan G, Consonni D, et al. Treatment with ferric carboxymaltose in stable patients with severe iron deficiency anemia in the emergency department. Intern Emerg Med  2020; 15(4): 629-34.
 [http://dx.doi.org/10.1007/s11739-019-02223-z] [PMID:  31707563]

[252]
Orhan MF, Büyükavci M. Intravenous iron therapy for children with iron deficiency anemia. J Pediatr Hematol Oncol  2023; 45(1): e56-9.
 [http://dx.doi.org/10.1097/MPH.0000000000002550] [PMID:  36161971]

[253]
Plummer ES, Crary SE, McCavit TL, Buchanan GR. Intravenous low molecular weight iron dextran in children with iron deficiency anemia unresponsive to oral iron. Pediatr Blood Cancer  2013; 60(11): 1747-52.
 [http://dx.doi.org/10.1002/pbc.24676] [PMID:  23832487]

[254]
Powers JM, Shamoun M, McCavit TL, Adix L, Buchanan GR. Intravenous ferric carboxymaltose in children with iron deficiency anemia who respond poorly to oral iron. J Pediatr  2017; 180: 212-6.
 [http://dx.doi.org/10.1016/j.jpeds.2016.09.053] [PMID:  27776750]

[255]
Schmugge M, Mattiello V, Hengartner H, von der Weid N, Renella R. Comment on: Intravenous ferric carboxymaltose for iron deficiency anemia or iron deficiency without anemia after poor response to oral iron treatment: Benefits and risks in a cohort of 144 children and adolescents. Pediatr Blood Cancer  2021; 68(3): e28726.
 [http://dx.doi.org/10.1002/pbc.28726] [PMID:  32969156]

[256]
Stein RE, Plantz K, Maxwell EC, Mamula P, Baldassano RN. Intravenous iron sucrose for treatment of iron deficiency anemia in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr  2018; 66(2): e51-5.
 [http://dx.doi.org/10.1097/MPG.0000000000001684] [PMID:  28704225]

[257]
Kaneva K, Chow E, Rosenfield CG, Kelly MJ. Intravenous iron sucrose for children with iron deficiency anemia. J Pediatr Hematol Oncol  2017; 39(5): e259-62.
 [http://dx.doi.org/10.1097/MPH.0000000000000879] [PMID:  28562517]

[258]
Ozsahin H, Schaeppi M, Bernimoulin M, Allard M, Guidard C, van den Ouweland F. Intravenous ferric carboxymaltose for iron deficiency anemia or iron deficiency without anemia after poor response to oral iron treatment: Benefits and risks in a cohort of 144 children and adolescents. Pediatr Blood Cancer  2020; 67(10): e28614.
 [http://dx.doi.org/10.1002/pbc.28614] [PMID:  32729200]

[259]
Berglund S, Westrup B, Domellöf M. Iron supplements reduce the risk of iron deficiency anemia in marginally low birth weight infants. Pediatrics  2010; 126(4): e874-83.
 [http://dx.doi.org/10.1542/peds.2009-3624] [PMID:  20819898]

[260]
Leung AKC, Sauve RS. Whole cow’s milk in infancy. Paediatr Child Health  2003; 8(7): 419-21.
 [http://dx.doi.org/10.1093/pch/8.7.419] [PMID:  20019947]

[261]
Robson WLM, Leung AKC. The use of cow’s milk in infancy. Pediatrics  1993; 91(2): 515-6.
 [http://dx.doi.org/10.1542/peds.91.2.515a] [PMID:  8424043]

[262]
Gill DG, Vincent S, Segal DS. Follow-on formula in the prevention of iron deficiency: A multicentre study. Acta Paediatr  1997; 86(7): 683-9.
 [http://dx.doi.org/10.1111/j.1651-2227.1997.tb08568.x] [PMID:  9240873]

[263]
Tunnessen WW Jr, Oski FA. Consequences of starting whole cow milk at 6 months of age. J Pediatr  1987; 111(6): 813-6.
 [http://dx.doi.org/10.1016/S0022-3476(87)80193-2] [PMID:  3681544]

[264]
Prieto-Patron A,V,, Hutton Z, Fattore G, Sabatier M, Detzel P. Reducing the burden of iron deficiency anemia in Cote D’Ivoire through fortification. J Health Popul Nutr  2020; 39(1): 1.
 [http://dx.doi.org/10.1186/s41043-020-0209-x] [PMID:  32033590]

[265]
Sun J, Zhang L, Cui J, et al. Effect of dietary intervention treatment on children with iron deficiency anemia in China: a meta-analysis. Lipids Health Dis  2018; 17(1): 108.
 [http://dx.doi.org/10.1186/s12944-018-0749-x] [PMID:  29747646]

[266]
Boutry M, Needlman R. Use of diet history in the screening of iron deficiency. Pediatrics  1996; 98(6): 1138-42.
 [http://dx.doi.org/10.1542/peds.98.6.1138] [PMID:  8951266]
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DOI https://dx.doi.org/10.2174/1573396320666230727102042	Print ISSN 1573-3963
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Current Pediatric Reviews

Iron Deficiency Anemia: An Updated Review

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