Title:Quorum Sensing in Gram-Negative Bacteria: Strategies to
Overcome Antibiotic Resistance in Ocular Infections
Volume: 24
Issue: 7
关键词:
抗生素，抗生素耐药性，群体感应，生物膜，群体感应抑制剂，眼部感染，革兰氏阴性菌。
摘要: Truly miraculous medications and antibiotics have helped save untold millions
of lives. Antibiotic resistance, however, is a significant issue related to health that
jeopardizes the effectiveness of antibiotics and could harm everyone's health. Bacteria,
not humans or animals, become antibiotic-resistant. Bacteria use quorum-sensing
communication routes to manage an assortment of physiological exercises. Quorum
sensing is significant for appropriate biofilm development. Antibiotic resistance occurs
when bacteria establish a biofilm on a surface, shielding them from the effects of
infection-fighting drugs. Acylated homoserine lactones are used as autoinducers by
gram-negative microscopic organisms to impart. However, antibiotic resistance among
ocular pathogens is increasing worldwide. Bacteria are a significant contributor to ocular
infections around the world. Gram-negative microscopic organisms are dangerous to
ophthalmic tissues. This review highlights the use of elective drug targets and
treatments, for example, combinational treatment, to vanquish antibiotic-resistant
bacteria. Also, it briefly portrays anti-biotic resistance brought about by gram-negative
bacteria and approaches to overcome resistance with the help of quorum sensing
inhibitors and nanotechnology as a promising medication conveyance approach to give
insurance of anti-microbials and improve pathways for the administration of inhibitors of
quorum sensing with a blend of anti-microbials to explicit target destinations and
penetration through biofilms for treatment of ocular infections. It centres on the
methodologies to sidestep the confinements of ocular anti-biotic delivery with new visual
innovation.
