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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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Review Article

Progression in the Relationship between Exosome Production and Atherosclerosis

Author(s): Yi Yang, Jinxi Luo, Yunan Kang, Wenqian Wu, Yajie Lu, Jie Fu, Xiaoyun Zhang, Min Cheng* and Xiaodong Cui*

Volume 25, Issue 9, 2024

Published on: 04 August, 2023

Page: [1099 - 1111] Pages: 13

DOI: 10.2174/1389201024666230726114920

Price: $65

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Abstract

Atherosclerosis (AS) is the leading cause of cardiovascular disease, causing a major burden on patients as well as families and society. Exosomes generally refer to various lipid bilayer microvesicles originating from different cells that deliver various bioactive molecules to the recipient cells, exerting biological effects in cellular communication and thereby changing the internal environment of the body. The mechanisms of correlation between exosomes and the disease process of atherosclerosis have been recently clarified. Exosomes are rich in nucleic acid molecules and proteins. For example, the exosome miRNAs reportedly play important roles in the progression of atherosclerotic diseases. In this review, we focus on the composition of exosomes, the mechanism of their biogenesis and release, and the commonly used methods for exosome extraction. By summarizing the latest research progress on exosomes and atherosclerosis, we can explore the advances in the roles of exosomes in atherosclerosis to provide new ideas and targets for atherosclerosis prevention, diagnosis, and treatment.

Keywords: Atherosclerosis, cardiovascular disease, exosome, extracellular vesicles, biogenesis, isolation technique.

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