Title:Targets Involved in Skin Aging and Photoaging and their Possible Inhibitors:
A Mini-review
Volume: 24
Issue: 10
关键词:
皮肤老化，光老化，分子对接，MMP-1，MMP-3，MMP-9，酪氨酸酶。
摘要:
Background: Skin aging is a natural process resulting from intrinsic (hormonal and genetic)
and extrinsic (environmental) factors. Photoaging occurs due to prolonged exposure of the
skin to ultraviolet radiation, accounting for 80% of facial aging.
Introduction: Characteristics of aging skin include reduced elasticity, the appearance of fine wrinkles,
uneven tone, and dryness. Clinical signs of photoaging involve the presence of deeper wrinkles,
rough texture, dyschromia and a greater loss of elasticity compared to chronological aging.
Methods: This work reported several scientific articles that used computational techniques, such as
molecular docking, molecular dynamics and quantitative structure-activity relationship (QSAR) to
identify natural products and their derivatives against skin aging and photoaging.
Results: The in silico analyses carried out by the researchers predicted the binding affinity and interactions
of the natural products with the targets matrix metalloproteinase-1, matrix metalloproteinase-
3, matrix metalloproteinase-9 and tyrosinase. Furthermore, some studies have reported the stability
of the protein-ligand complex and the physicochemical properties of the studied compounds.
Finally, this research proposes promising molecules against the targets.
Conclusion: Thus, studies like this one are relevant to guide new research related to skin aging and
photoaging.
