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Review Article

皂苷作为有前途的抗布氏锥虫化合物的前景：对作用机制的洞察

卷 24, 期 10, 2023

发表于: 27 July, 2023

页: [838 - 855] 页: 18

弟呕挨: 10.2174/1389450124666230719105147

价格: $65

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摘要

背景：非洲人类锥虫病 (HAT) 是一种寄生虫感染，如果不及时治疗可能会导致死亡。这种疾病是由锥虫属原生动物寄生虫引起的，并通过采采蝇叮咬传播给人类。该疾病在撒哈拉以南非洲地区广泛传播，最近报告中 70% 的病例发生在刚果民主共和国，平均每年报告的病例不到 1000 例。由于 HAT 没有适当的治疗方法，据报道，类固醇和三萜皂苷在体外研究中是有效的，并且可以作为发现针对该疾病的新疗法的支架。 研究目的：本研究旨在总结有关类固醇和三萜皂苷抗布氏锥虫活性的最新信息。还讨论了体外生物活性化合物的作用机制。 方法：通过各种图书馆和电子数据库从已发表的文章、论文、论文和教科书中获得有关植物皂苷抗布氏锥虫活性的信息。 结果：在鉴定具有显着体外抗布氏锥虫活性的甾体皂苷和三萜皂苷方面取得了令人难以置信的进展。事实上，超过 40 种皂苷被鉴定为具有抗 T 蛋白。 brucei 效应的活性范围从中度到高度活性。大多数这些皂苷的作用机制包括 DNA 损伤、细胞周期停滞、通过下调 bcl-2 和 MDM2 以及上调 Bax 和 Bak 诱导细胞凋亡等。 结论：根据体外研究，植物皂苷具有抗布氏锥虫活性；然而，应进一步考虑更多的细胞毒性和体内研究以及生物活性皂苷的详细作用机制。

关键词: 人类非洲锥虫病，皂苷，布氏锥虫，合成，结构修饰，毒性。

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