Title:A Unique Perspective on Lead Compounds for Dementia with the Lewy
Body
Volume: 19
Issue: 10
Author(s): Menaka Subramani*, Amuthalakshmi Sivaperuman, Ramalakshmi Natarajan and Keerthana Dhinakaran
Affiliation:
- Department of Pharmaceutical Chemistry, C.L. Baid Metha College of Pharmacy, Chennai, India
Keywords:
α-Synuclein, presynaptic protein, dementia, Lewy body, Parkinson's disease, α-Synuclein aggregation inhibitors.
Abstract: Dementia with Lewy Bodies is a neurodegenerative disorder characterised by abnormal α-
synuclein aggregate accumulation in Lewy Bodies and Lewy Neurites and the most common form of
dementia after Alzheimer’s disease. The presynaptic protein alpha-synuclein (α-Syn) regulates synaptic
vesicle trafficking and the subsequent release of neurotransmitters in the brain. These aggregates
go through a number of crucial stages, such as aggregation, oligomerization, and fibrillation.
Treatment of this disorder is generally symptomatic. This necessitates the development of cuttingedge
therapeutic approaches that can either stop or change the course of the diseases. Many studies
have shown that α-synuclein is a significant therapeutic target and that inhibiting α-synuclein aggregation,
oligomerization, and fibrillation is an important disease-modifying strategy. Since α-syn is a
defining feature of Parkinson’s disease, the current review provides an overview of plant phytochemicals
and synthetic heterocyclic compounds that target α-syn in Parkinson's disease in order to develop
new drugs for Dementia with Lewy Bodies.