Title:Pathophysiology, Current Therapeutic Options, Vaccine Candidates, and Drug
Targets for Human Brucellosis
Volume: 17
Author(s): Manisha Pritam and Rajnish Kumar*
Affiliation:
- Amity Institute of Biotechnology, Amity University Uttar Pradesh Lucknow Campus, Uttar Pradesh, India
- Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
Keywords:
Brucellosis, Drug target, Pathophysiology, Vaccine candidate, Inhibition of apoptosis, Rose Bengal test (RBT).
Abstract: Brucellosis is an infectious disease caused by different species of Brucella bacteria. It is also known as Malta fever, one of the neglected diseases
that can cause infection in both animals and humans. Although human-to-human infection is rare, it can spread through the inhalation of airborne
agents, and if left untreated, it can lead to serious health complications. In this review, we aim to highlight the pathophysiology, prevention,
epidemiology, mitigation, cure, targets for drug development, and vaccine development against human brucellosis. Human brucellosis is mainly
caused by consuming unpasteurized milk or dairy products, uncooked meat, and contact with infected animals. Human brucellosis outbreaks are
mainly associated with developing and low- to middle-income countries. Brucella is present all over the world, and only some of the regions are at
high risk, including Asia, Africa, Eastern Europe, Mexico, South and Central America, the Caribbean, the Mediterranean Basin, and the Middle
East. Because of intracellular survival, inhibition of apoptosis, and immune evasion, Brucella can survive and multiply inside the host cell, which
can cause chronic disease. By using proteomics approaches, several new drug targets were reported for human brucellosis that can be used for the
development of novel drugs. We can also develop an efficient vaccine against human brucellosis by exploring previously reported vaccine
candidates against animal brucellosis. The information provided through this review will facilitate research to control and cure human brucellosis
and its complicated symptoms.
