Title:A Comprehensive Review on the Neuropharmacological Effects of
Antidepressants in Various Prospects
Volume: 12
Author(s): Sandesh Varshney, Md. Aftab Alam*, Awaneet Kaur*Shaweta Sharma*
Affiliation:
- Department of Pharmacy, School of Medical and Allied Sciences, Professor,
Galgotias University, Greater Noida, Uttar Pradesh, India
- Department of Pharmacy, School of Medical and Allied
Sciences, Assistant Professor, Galgotias University, Greater Noida, Uttar Pradesh, India
- Department of Pharmacy,
School of Medical and Allied Sciences, Professor, Galgotias University, Greater Noida, Uttar Pradesh, India
Keywords:
Depression, disabling illness, behavioural analytic perspective, antidepressant drugs, 5-HT-mediated neurotransmission, transdermal.
Abstract: Depression is one of the most challenging diseases for society to treat. It is a highly prevalent
and disabling illness in the general population. Affective disorders are characterised by depressed
mood, diminished interest and pleasure, feelings of guilt or poor self-worth, sleep or food difficulties,
decreased energy, and impaired attention. This manuscript will look at depression from a behavioural
analytic perspective. The pathogenesis of major depressive disorder is poorly understood. Several
lines of experimental and clinical evidence, however, show that the therapeutic effect of most antidepressant
drugs is related to an increase in 5-HT-mediated neurotransmission. Alternative techniques,
however, are employed to obtain this net effect. A better understanding of the neurological mechanism
underpinning antidepressant drugs' delayed onset of action has resulted in the development of ways to
accelerate antidepressant responses, which are discussed further below. Many antidepressant medications
on the market today are beneficial, but they come with many downsides, including unpleasant
side effects, potential interactions, and a low response rate. Natural drugs, on the other hand, are extremely
effective, have a low risk, and a limited amount of side effects, which are covered briefly in
this paper. Alternative modalities of administration have received a lot of attention in recent decades
as a complement to approved prescription pharmaceuticals, especially for people who cannot tolerate
oral or parenteral methods. The most promising non-invasive systemic delivery techniques are transdermal
and transbronchial administration, and these are the focus of this research.
