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Review Article

Recent Progress in Synthetic Chemistry and Biological Activities of Pyrimido[ 4,5-b] Quinoline Derivatives (Part III)

Author(s): Moustafa A. Gouda*, Ameen A. Abu-Hashem*, Tahah A. Ameen, Mohammed A. Salem and Ateyatallah Aljuhani*

Volume 21, Issue 7, 2024

Published on: 20 July, 2023

Page: [779 - 792] Pages: 14

DOI: 10.2174/1570193X20666230626101436

Price: $65

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Abstract

Amongst heterocyclic compounds, quinoline and pyrimidine are advantaged scaffolds that appear as significant assembly motifs for the development of new drug entities. Moreover, quinolinepyrimidine- inspired hybrids have a number of biological characteristics that are known. In addition, many pyrimido[4,5-b]quinoline ring systems (PyQs4,5-b), specifically concerning medicinal chemistry, have been reported over the past decade. The synthesis of (PyQs4,5-b) using barbituric acid, thiobarbituric acid, pyrimidine, and their derivatives is presented in this review. The preparation of PyQs4,5-b was clarified through the following chemical reactions: Friedländer, Vilsmeier-Haack formylation, Hantzsch-like reaction, and one-pot three-component reaction.

Keywords: Barbituric acid, thiobarbituric acid, vilsmeier-haack formylation, one-pot multi-component, friedländer reaction, pyrimidoquinoline.

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