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Review Article

Edible Herbal Medicines as an Alternative to Common Medication for Sleep Disorders: A Review Article

Author(s): Azar Hosseini, Leila Mobasheri, Hassan Rakhshandeh, Vafa Baradaran Rahimi, Zohreh Najafi and Vahid Reza Askari*

Volume 22, Issue 7, 2024

Published on: 22 June, 2023

Page: [1205 - 1232] Pages: 28

DOI: 10.2174/1570159X21666230621143944

Price: $65

Open Access Journals Promotions 2
Abstract

Insomnia is repeated difficulty in falling asleep, maintaining sleep, or experiencing lowquality sleep, resulting in some form of daytime disturbance. Sleeping disorders cause daytime fatigue, mental confusion, and over-sensitivity due to insufficient recovery from a sound sleep. There are some drugs, such as benzodiazepines and anti-histaminic agents, which help to sleep induction and insomnia cure. However, the prolonged administration is unsuitable because of tolerance and dependence. Therefore, the researchers attempt to find new medicines with lesser adverse effects. Natural products have always been good sources for developing new therapeutics for managing diseases such as cancer, cardiovascular disease, diabetes, insomnia, and liver and renal problems. Ample research has justified the acceptable reason and relevance of the use of these herbs in the treatment of insomnia. It is worth noting that in this study, we looked into various Persian herbs in a clinical trial and in vivo to treat insomnia, such as Artemisia annua, Salvia reuterana, Viola tricolor, Passiflora incarnata, lettuce, and Capparis spinose. According to research, herb extracts and fractions, particularly n-butanol fractions with non-polar agents, impact the benzodiazepine receptors and have hypnotic properties. Also, alkaloids, glycosides, flavonoids, saponins, and tannins in practically every plant are mentioned making them the popular natural compounds to help with sleep disorders and promote calmness.

Keywords: Sleep, inflammation, herbal medicine, benzodiazepines, GABAergic system, oxidative stress.

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