Title:Emerging Nanotechnology-based Therapeutics: A New Insight into
Promising Drug Delivery System for Lung Cancer Therapy
Volume: 18
Issue: 4
Author(s): Ravinder Verma*, Lakshita Rao, Diksha Nagpal, Manish Yadav, Vivek Kumar, Vikram Kumar, Harish Kumar, Jatin Parashar, Nitin Bansal, Manish Kumar, Parijat Pandey, Vineet Mittal and Deepak Kaushik
Affiliation:
- Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, 127021, India
Keywords:
Nanomedicine, lung cancer, solid lipid nanoparticles, liposomes, dendrimers, niosomes, nanoemulsions.
Abstract:
Background: Lung cancer is a foremost global health issue due to its poor diagnosis. The
advancement of novel drug delivery systems and medical devices will aid its therapy.
Objective: In this review, the authors thoroughly introduce the ideas and methods for improving nanomedicine-
based approaches for lung cancer therapy. This article provides mechanistic insight into various
novel drug delivery systems (DDSs) including nanoparticles, solid lipid nanoparticles, liposomes,
dendrimers, niosomes, and nanoemulsions for lung cancer therapy with recent research work. This review
provides insights into various patents published for lung cancer therapy based on nanomedicine.
This review also highlights the current status of approved and clinically tested nanoformulations for
their treatment.
Methodology: For finding scholarly related data for the literature search, many search engines were
employed including PubMed, Science Direct, Google, Scihub, Google Scholar, Research Gate, Web of
Sciences, and several others. Various keywords and phrases were used for the search such as “nanoparticles”,
“solid lipid nanoparticles”, “liposomes”, “dendrimers”, “niosomes”, “nanoemulsions”, “lung
cancer”, “nanomedicine”, “nanomaterial”, “nanotechnology”, “in vivo” and “in vitro”. The most innovative
and cutting-edge nanotechnology-based approaches that are employed in pre-clinical and clinical
studies to address problems associated with lung cancer therapies are also mentioned in future prospects.
A variety of problems encountered with current lung cancer therapy techniques that frequently
led to inadequate therapeutic success are also discussed in the end.
Conclusion: The development of nanoformulations at the pilot scale still faces some difficulties, but
their prospects for treating lung cancer appear to be promising in the future. Future developments and
trends are anticipated as the evaluation comes to a close.
