Title:Brain-Derived Neurotrophic Factor – The Protective Agent Against Neurological Disorders
Volume: 23
Issue: 3
Author(s): Prathyusha Koyya, Ram Kumar Manthari*Santhi Latha Pandrangi
Affiliation:
- Department of Biotechnology, GITAM School of Science, Gandhi Institute of Technology and Management (Deemed
to be University), Visakhapatnam-530045, Andhra Pradesh, India
Keywords:
Autophagy, cognitive impairment, brain-derived neurotrophic factors, BDNF receptors, neurogenesis, synaptic plasticity.
Abstract: The burden of neurological illnesses on global health is significant. Our perception of the
molecular and biological mechanisms underlying intellectual processing and behavior has significantly
advanced over the last few decades, laying the groundwork for potential therapies for various neurodegenerative
diseases. A growing body of literature reveals that most neurodegenerative diseases
could be due to the gradual failure of neurons in the brain's neocortex, hippocampus, and various subcortical
areas. Research on various experimental models has uncovered several gene components to
understand the pathogenesis of neurodegenerative disorders. One among them is the brain-derived
neurotrophic factor (BDNF), which performs several vital functions, enhancing synaptic plasticity and
assisting in the emergence of long-term thoughts. The pathophysiology of some neurodegenerative
diseases, including Alzheimer’s, Parkinson’s, Schizophrenia, and Huntington’s, has been linked to
BDNF. According to numerous research, high levels of BDNF are connected to a lower risk of developing
a neurodegenerative disease. As a result, we want to concentrate on BDNF in this article and
outline its protective role against neurological disorders.