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ISSN (Print): 1574-8928
ISSN (Online): 2212-3970

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Perspective

Unlocking Delivery Strategies for mRNA Therapeutics

Author(s): Zhiyuan Luo and Yangchao Chen*

Volume 19, Issue 2, 2024

Published on: 23 June, 2023

Page: [126 - 129] Pages: 4

DOI: 10.2174/1574892818666230607093231

Abstract

mRNA emerged as an attractive therapy modality with the development of mRNA structure engineering techniques and delivery platforms. mRNA therapeutics, applied for vaccine therapy, protein replacement therapy, and chimeric antigen receptor (CAR) T cell-based therapy, has shown huge potential in treating a wide range of diseases, such as cancer and rare genetic diseases, with successful and exciting preclinical and clinical progress. In mRNA therapeutics, a potent delivery system is key to the success of its application for disease treatment. Herein, different types of mRNA delivery strategies, including nanoparticles produced from lipid or polymer materials, virus-based platforms, and exosome-based platforms, are mainly focused.

Keywords: mRNA delivery, mRNA therapeutics, nucleic acid delivery, gene therapy, delivery system, nanoparticle.

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