The Role of Resveratrol in Aging and Senescence: A Focus on
Molecular Mechanisms

Zeynab      Kohandel; Majid      Darrudi; Kobra      Naseri; Fariborz      Samini; Michael      Aschner; Ali   Mohammad   Pourbagher-Shahri; Saeed      Samarghandian
doi:10.2174/1566524023666230602162949
Abstract

Resveratrol (Res), a polyphenol found in red wine, has been shown to decelerate aging, the progressive loss of physiological integrity and cellular senescence, characterized by the inability to progress through the cell cycle. No successful clinical trials have yet to be completed in humans on dose limitations. Yet, the potent anti-aging and anti-senescence efficacy of Res has been documented in several in vivo animal models. In this review, we highlight the molecular mechanisms of Res efficacy in antiaging disorders, such as diabetes, neurodegenerative disorders, eye diseases, and cardiovascular diseases.
Keywords: Resveratrol, aging, senescence, molecular mechanisms, oxidative stress, inflammation.
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DOI https://dx.doi.org/10.2174/1566524023666230602162949	Print ISSN 1566-5240
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