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Review Article

调节人类癌症中细胞活性及其相关信号通路的转移RNA衍生的小RNA失调

卷 23, 期 4, 2023

发表于: 08 June, 2023

页: [291 - 303] 页: 13

弟呕挨: 10.2174/1566523223666230601102506

价格: $65

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摘要

tsRNA是源自tRNA切割的小的非编码RNA，在基因表达、翻译、转录和表观遗传修饰中起重要的调控作用。癌症中tsRNA的失调会破坏基因表达并扰乱各种细胞活动，包括细胞增殖，凋亡，迁移和侵袭。此外，tsRNA可能通过调节相关的细胞信号通路来影响癌症的发展。在本综述中，我们首先研究了tsRNA的起源和分类及其对肿瘤细胞活性的影响。为了突出tsRNA和信号通路的最新研究进展，我们总结了tsRNA在特定肿瘤相关信号通路中的可能机制，包括最近研究中已发现的Wnt，TGFb1，MAPK，PI3K-AKT，Notch和MDM2 / p53信号通路。

关键词: tsRNA，tRFs，癌症，失调，细胞活性，信号通路。

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图形摘要

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