Title:Dysregulation of Transfer RNA-derived Small RNAs that Regulate Cell
Activity and its Related Signaling Pathways in Human Cancers
Volume: 23
Issue: 4
Author(s): Tianyi Huang, Juan Du, Chujia Chen, Zhen Zheng, Shuai Fang*Kaitai Liu*
Affiliation:
- Department of Thoracic Surgery,
The Affiliated Hospital of Medical School of Ningbo University, Ningbo, 315020, Zhejiang, China
- Department of Radiation Oncology,
The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315040, Zhejiang, China
Keywords:
tsRNAs, tRFs, cancer, dysregulation, cell activity, signaling pathway.
Abstract: tsRNAs are small noncoding RNAs that originate from tRNA cleavage and play important
regulatory roles in gene expression, translation, transcription, and epigenetic modification. The
dysregulation of tsRNAs in cancer disrupts gene expression and perturbs various cellular activities,
including cell proliferation, apoptosis, migration, and invasion. Moreover, tsRNAs may influence cancer
development by regulating related cell signaling pathways. In this review, we first examine the origins
and classification of tsRNAs and their effects on tumor cell activity. To highlight the latest research
progress of tsRNAs and signaling pathways, we summarize the possible mechanisms of tsRNAs
in specific tumor-related signaling pathways, including the Wnt, TGFb1, MAPK, PI3K-AKT,
Notch, and MDM2/p53 signaling pathways, that have been identified in recent research.