Title:Recent Approaches to Enhance Osteogenesis of Dental Pulp Stem Cells on
Electrospun Scaffolds
Volume: 19
Issue: 5
Author(s): Zahra Safari, Seyedeh Sara Aghili, Sahar Hassantash, Ehsan Iranmanesh, Mehdi Abouali, Mobina Bagherianlemraski, Shabnam Ghasemzadeh, Esmaeel Dadgar, Ghasem Barati*Ehsan Saburi*
Affiliation:
- Stem Cell Technology Research Center, Tehran, Iran
- Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Keywords:
Osteogenesis, dental pulp stem cells, electrospinning, scaffold modification, tissue engineering.
Abstract: Critical-sized bone defects are a challenging issue during bone regeneration. Bone tissue engineering
is aimed to repair such defects using biomimicking scaffolds and stem cells. Electrospinning allows
the fabrication of biocompatible, biodegradable, and strengthened scaffolds for bone regeneration.
Natural and synthetic polymers, alone or in combination, have been employed to fabricate scaffolds with
appropriate properties for the osteogenic differentiation of stem cells. Dental pulps are rich in stem cells,
and dental pulp stem cells (DPSCs) have a high capacity for proliferation, differentiation, immunomodulation,
and trophic factor expression. Researchers have tried to enhance osteogenesis through scaffold
modification approaches, including incorporation or coating with mineral, inorganic materials, and herbal
extract components. Among them, the incorporation of nanofibers with hyaluronic acid (HA) has been
widely used to promote osteogenesis. In this review, the electrospun scaffolds and their modifications
used in combination with DPSCs for bone regeneration are discussed.