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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Mini-Review Article

Dichlorophosphoryl Isocyanate: Synthesis, Chemical Reactions, and Biological Activity of its Derivatives

Author(s): Faten Medini, Lotfi Mohamed Aroua and Nejib Ben Hussein Mekni*

Volume 21, Issue 8, 2024

Published on: 17 July, 2023

Page: [833 - 851] Pages: 19

DOI: 10.2174/1570193X20666230526104159

Price: $65

Abstract

Dichlorophosphoryl isocyanate (DCPI) is the most basic and easy phosphoric isocyanate substrate that introduces organic moieties. Synthesized since 1954, the DCPI has a high reactivity toward primary and secondary alkyl, alcohols, phenols, thiols, and amines via the nucleophilic addition reaction on the carbon atom of the isocyanate group. In addition to their synthesis, the resulting products undergo nucleophilic substitutions of the chlorine atoms. Their reactions with nucleophilic and bi-nucleophile reagents yield acyclic and P-heterocyclic compounds, respectively. The resulting compounds have different potential antibacterial, antifungal, and antitumor activities.

Keywords: Dichlorophosphoryl isocyanate, difluorophosphoryl isocyanate, organophosphoryl, carbamate, urea, antifungal, antibacterial, antitumor, biological activity.

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