Title:Hypothesizing the Green Synthesis of Tamoxifen Loaded Magnetic
Nanoparticles for the Treatment of Breast Cancer
Volume: 24
Issue: 5
Author(s): Neha Tyagi, Tanya Ralli, Asgar Ali and Kanchan Kohli*
Affiliation:
- Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi,
110062, India
- Lloyd Institute of Management and Technology, Knowledge Park II, Greater Noida, Uttar
Pradesh, India
Keywords:
Breast cancer, green nanotechnology, tamoxifen, magnetic metallic nanoparticles, anti-oxidant, targeted therapy.
Abstract:
Breast cancer is the second leading cause of death all over the world and is
not only limited to females but also affects males. For estrogen receptor-positive breast
cancer, tamoxifen has been considered the gold-line therapy for many decades.
However, due to the side effects associated with the use of tamoxifen, its use is only
limited to individuals in high-risk groups and limits its clinical application to moderate
and/or lower-risk groups. Thus, there is a necessity to decrease the dose of tamoxifen,
which can be achieved by targeting the drug to breast cancer cells and limiting its
absorption to other body parts.
Artificial antioxidants used in the formulation preparation are assumed to upsurge the
risk of cancer and liver damage in humans. The need of the hour is to explore bioefficient
antioxidants from natural plant sources as they are safer and additionally
possess antiviral, anti-inflammatory, and anticancer properties.
The objective of this hypothesis is to prepare tamoxifen-loaded PEGylated NiO
nanoparticles using green chemistry, tumbling the toxic effects of the conventional
method of synthesis for targeted delivery to breast cancer cells.
The significance of the work is to hypothesize a green method for the synthesis of NiO
nanoparticles that are eco-friendly, cost-effective, decrease multidrug resistance, and
can be used for targeted therapy. Garlic extract contains an organosulfur compound
(Allicin) which has drug-metabolizing, anti-oxidant, and tumour growth inhibition effects.
In breast cancer, allicin sensitizes estrogen receptors, increasing the anticancer efficacy
of tamoxifen and reducing offsite toxicity. Thus, this garlic extract would act as a
reducing agent and a capping agent. The use of nickel salt can help in targeted delivery
to breast cancer cells and, in turn, reduces drug toxicity in different organs.
This novel strategy may aim for cancer management with less toxic agents acting as an
apt therapeutic modality.
