Title:Conditioned Media Therapy in Alzheimer's Disease: Current Findings and
Future Challenges
Volume: 19
Issue: 5
Author(s): Amin Firoozi, Mehri Shadi, Zohre Aghaei and Mohammad Reza Namavar*
Affiliation:
- Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
- Histomorphometry and Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
- Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Keywords:
Alzheimer’s disease, Conditioned media, Stem cell, Neurodegenerative disease, cytokines, chemokines.
Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder accompanied by a reduction in cognition
and memory. Till now, there is no definite cure for AD, although, there are treatments available
that may improve some symptoms. Currently, in regenerative medicine stem cells are widely used, mainly
for treating neurodegenerative diseases. There are numerous forms of stem cells to treat AD aiming at the
expansion of the treatment methods for this particular disease. Since 10 years ago, science has gained
abundant knowledge to treat AD by understanding the sorts of stem cells, methods, and phasing of injection.
Besides, due to the side effects of stem cell therapy like the potentiation for cancer, and as it is hard
to follow the cells through the matrix of the brain, researchers have presented a new therapy for AD. They
prefer to use conditioned media (CM) that are full of different growth factors, cytokines, chemokines,
enzymes, etc. without tumorigenicity or immunogenicity such as stem cells. Another benefit of CM is that
CM could be kept in the freezer, easily packaged, and transported, and doesn’t need to fit with the donor.
Due to the beneficial effects of CM, in this paper, we intend to evaluate the effects of various types of CM
of stem cells on AD.