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Current Medical Imaging

Editor-in-Chief

ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

Case Report

Huge Primary Clear Cell Hepatocellular Carcinoma: A Case Report and Review of Radiologic Findings

Author(s): Junhyeon Jeon, Jinyoung Park*, Eunjoo Lee, Jiyeon Han, Dasom Kim, Donghyun Kim, Jungwon Park, Minha Kwag, Suyoung Yun and Hayoung Park

Volume 20, 2024

Published on: 16 August, 2023

Article ID: e220523217193 Pages: 5

DOI: 10.2174/1573405620666230522144730

open_access

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Abstract

Introduction: Clear cell hepatocellular carcinoma (HCC) is a rare subtype of HCC. Histologically, clear cell HCC is characterized by the cytoplasmic accumulation of glycogen with a clear cell appearance, constituting > 80% of tumor cells. Radiologically, clear cell HCC demonstrates early enhancement and washout similar to conventional HCC. Occasionally, enhancing capsule and intratumoral fat are accompanied by clear cell HCC.

Case Description: A 57-year-old male presented to our hospital with right upper quadrant abdominal pain. Ultrasonography, computed tomography, and magnetic resonance imaging revealed a large mass with a well-defined margin in the right hemiliver. The patient underwent a right hemihepatectomy, and the final histopathology revealed clear cell-type HCC.

Conclusion: Distinguishing clear cell types from other types of HCC solely based on radiological findings is challenging. If hepatic tumors exhibit encapsulated margins, enhancing rims, intratumoral fat, and arterial phase hyperenhancement/washout pattern despite their large size, consideration of clear cell subtypes in the differential diagnosis list will aid patient management, implying better prognosis than not-otherwise-specified HCC.

Keywords: Clear cell, Carcinoma, Hepatocellular, Computed tomography, Magnetic resonance imaging, Liver.


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