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当代肿瘤药物靶点

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Letter Article

DNMT3B抑制剂纳那霉素A作为神经母细胞瘤治疗剂

卷 23, 期 11, 2023

发表于: 13 June, 2023

页: [837 - 842] 页: 6

弟呕挨: 10.2174/1568009623666230522113645

价格: $65

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摘要

背景:神经母细胞瘤是儿童最常见的实体瘤之一。由于肿瘤抑制基因通常在癌症中高度甲基化,DNA甲基化已成为癌症治疗的靶点。据报道,纳那霉素A是一种DNA甲基转移酶3B的抑制剂,介导DNA甲基化的从头开始,在几种类型的人类癌症细胞中诱导死亡。 目的:研究纳米霉素A对神经母细胞瘤细胞株的抗肿瘤活性及其作用机制。 方法:根据细胞活力、DNA甲基化水平、凋亡相关蛋白表达和神经元相关mRNA表达,评价纳霉素A对神经母细胞瘤细胞系的抗肿瘤作用。 结果:纳那霉素A可降低人神经母细胞瘤细胞基因组DNA甲基化水平,诱导细胞凋亡。纳那霉素A还上调了与神经元成熟相关的几个基因的mRNA表达。 结论:纳那霉素A是治疗神经母细胞瘤的有效候选药物。我们的研究结果还表明,抑制DNA甲基化是一种很有前途的神经母细胞瘤抗肿瘤治疗策略。

关键词: 神经母细胞瘤,DNA甲基化,表观遗传学,DNA甲基转移酶3B,纳米霉素A,细胞凋亡。

图形摘要
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