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Review Article

膳食植物化学物质在靶向人类miRNA预防和治疗癌症中的作用

卷 23, 期 5, 2023

发表于: 05 June, 2023

页: [343 - 355] 页: 13

弟呕挨: 10.2174/1566523223666230519124519

价格: $65

Open Access Journals Promotions 2
摘要

MicroRNA（miRNA - 约 22 个核苷酸）是一种参与转录后基因沉默的非编码 RNA。已知它们在多种生物过程中调节基因表达，例如细胞凋亡、发育和分化。多项研究表明，癌症的发生和进展受到 miRNA 表达的高度调控。饮食中存在的营养素可以调节癌发生的不同阶段。有趣的是，植物性食品，如水果和蔬菜，已被证明在预防癌症方面发挥着重要作用。植物化学物质是从植物中提取的生物活性化合物，已被证明具有抗炎、抗氧化和抗癌特性。最近的研究结果表明，膳食植物化学物质，如金雀花素、白藜芦醇和姜黄素，通过调节各种 miRNA 发挥显着的抗癌作用。在这篇综述中，我们重点关注膳食植物化学物质通过调节 miRNA 表达在癌症预防和治疗中的作用。

关键词: miRNA，植物化学物质，姜黄素，非编码基因，miR-21，癌症。

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图形摘要

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