Title:Therapeutic Viewpoint on Rat Models of Locomotion Abnormalities and
Neurobiological Indicators in Parkinson's Disease
Volume: 23
Issue: 4
Author(s): Rishabh Chaudhary*Randhir Singh*
Affiliation:
- Department of Pharmacology, Central University of Punjab, Bathinda 151401, India
- Department of Pharmacology,
M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana
133207, India
- Department of Pharmacology, Central University of Punjab, Bathinda 151401, India
Keywords:
Parkinson’s disease, locomotion abnormalities, animal models, neurobiological indicators, therapeutic options, neurotoxin 6-hydroxydopamine, pedunculopontine nucleus, alpha-synuclein.
Abstract:
Background: Locomotion problems in Parkinson's syndrome are still a research and treatment
difficulty. With the recent introduction of brain stimulation or neuromodulation equipment that is
sufficient to monitor activity in the brain using electrodes placed on the scalp, new locomotion investigations
in patients having the capacity to move freely have sprung up.
Objective: This study aimed to find rat models and locomotion-connected neuronal indicators and use
them all over a closed-loop system to enhance the future and present treatment options available for
Parkinson’s disease.
Methods: Various publications on locomotor abnormalities, Parkinson's disease, animal models, and
other topics have been searched using several search engines, such as Google Scholar, Web of Science,
Research Gate, and PubMed.
Results: Based on the literature, we can conclude that animal models are used for further investigating
the locomotion connectivity deficiencies of many biological measuring devices and attempting to address
unanswered concerns from clinical and non-clinical research. However, translational validity is required
for rat models to contribute to the improvement of upcoming neurostimulation-based medicines. This review
discusses the most successful methods for modelling Parkinson’s locomotion in rats.
Conclusion: This review article has examined how scientific clinical experiments lead to localised
central nervous system injuries in rats, as well as how the associated motor deficits and connection oscillations
reflect this. This evolutionary process of therapeutic interventions may help to improve locomotion-
based treatment and management of Parkinson's syndrome in the upcoming years.